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Eimer, Johannes; Patimeteeporn, Calvin; Jensenius, Mogens; Gkrania-Klotsas, Effrossyni; Duvignaud, Alexandre; Barnett, Elizabeth D; Hochberg, Natasha S; Chen, Lin H; Trigo-Esteban, Elena; Gertler, Maximilian; Greenaway, Christina; Grobusch, Martin P; Angelo, Kristina M; Hamer, Davidson H; Caumes, Eric; Asgeirsson, Hilmir
Journal of travel medicine, 08/2021, Letnik: 28, Številka: 6Journal Article
Abstract Background Early detection of imported multidrug-resistant tuberculosis (MDR-TB) is crucial, but knowledge gaps remain about migration- and travel-associated MDR-TB epidemiology. The aim was to describe epidemiologic characteristics among international travellers and migrants with MDR-TB. Methods Clinician-determined and microbiologically confirmed MDR-TB diagnoses deemed to be related to travel or migration were extracted from GeoSentinel, a global surveillance network of travel and tropical medicine clinics, from January 2008 through December 2020. MDR-TB was defined as resistance to both isoniazid and rifampicin. Additional resistance to either a fluoroquinolone or a second-line injectable drug was categorized as pre-extensively drug-resistant (pre-XDR) TB, and as extensively drug-resistant (XDR) TB when resistance was detected for both. Sub-analyses were performed based on degree of resistance and country of origin. Results Of 201 patients, 136 had MDR-TB (67.7%), 25 had XDR-TB (12.4%), 23 had pre-XDR TB (11.4%) and 17 had unspecified MDR- or XDR-TB (8.5%); 196 (97.5%) were immigrants, of which 92 (45.8%) originated from the former Soviet Union. The median interval from arrival to presentation was 154 days (interquartile range IQR: 10–751 days); 34.3% of patients presented within 1 month after immigration, 30.9% between 1 and 12 months and 34.9% after ≥1 year. Pre-XDR- and XDR-TB patients from the former Soviet Union other than Georgia presented earlier than those with MDR-TB (26 days IQR: 8–522 vs. 369 days IQR: 84–827), while patients from Georgia presented very early, irrespective of the level of resistance (8 days IQR: 2–18 vs. 2 days IQR: 1–17). Conclusions MDR-TB is uncommon in traditional travellers. Purposeful medical migration may partly explain differences in time to presentation among different groups. Public health resources are needed to better understand factors contributing to cross-border MDR-TB spread and to develop strategies to optimize care of TB-infected patients in their home countries before migration.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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