HVE has designed a range of high-current Tandetrons TM with terminal voltages of 1 MV up to 6 MV. Characteristic for the accelerator design is the coaxial construction of the all-solid-state power supply that is wrapped around the high-energy acceleration tube. Equipped with a new all-solid-state RF driver, the Tandetrons TM are able to provide ion beams with output powers in excess of 10 kW and are as such suitable for applications like neutron production in biomedical research, boron neutron capture therapy, isotope production for positron emission tomography, as well as explosives detection using pulsed fast neutron analysis. Recently, a 1.25 MV version has passed the pre-delivery factory tests during which it was conditioned up to 1.5 MV and has delivered more than 1 mA target current. It will be used as a source of intermediate energy neutrons for the quantification of Al in human tissues. This specific application draws on the high-current capability of the Tandetron TM. The injector is equipped with one multi-cusp ion source, but injectors can comprise two multi-cusp ion sources with output currents of up to several mA's for H/D and more than 100 μA for He. A 2 MV/1 mA version of the high-current range is currently under construction for the National Institute of Radiological Sciences (NIRS), Chiba, Japan. A recently installed 5 MV version of this range of Tandetrons TM dedicated to scientific research has demonstrated terminal voltage ripple below 10 −5 as well as an extremely fast transient response.