The region of the Middle East has been for centuries space of interweaving of interests of power holders, both within the countries of the region and major world powers. The favorable geographical position and significant reserves of natural resources, principally oil, make the Middle East, in terms of security, very sensitive. Clash of civilizations and religions in the region and the locations of the most important holy places for both Christianity and Islam was historically a stumbling rock and a great obstacle to peace and prosperity. The aim of this article is to point out and to attempt to answer the question of how Islamic State can influence on global security. Considering the complexity of the security reality in the Middle East, it can be said that the importance is reflected in the fact that it provides a contribution to its knowing the aspect that arises from the problem issues.