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A variant in FTO shows association with melanoma risk not due to BMIIles, Mark M. ...We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL ... consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanoma-susceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.Source: Nature genetics. - ISSN 1061-4036 (Vol. 45, no. 4, 2013)Type of material - article, component part ; adult, seriousPublish date - 2013Language - englishCOBISS.SI-ID - 1472635
Author
Iles, Mark M. |
Novaković, Srdjan |
Hočevar, Marko, 1964-
Topics
Melanoma |
Genetics |
Genotype |
Body mass index |
Genome-wide association study |
Statistics and numerical data |
melanomi |
genotipi |
študije
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Iles, Mark M. | ![]() |
Novaković, Srdjan | 08007 |
Hočevar, Marko, 1964- | 12023 |
Source: Personal bibliographies
and: SICRIS
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