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Linearity of eprinomectin pharmacokinetics in lactating dairy sheep following pour-on administration: excretion in milk and exposure of suckling lambsHodošček, Lena ...Pharmacokinetics of eprinomectin (EPR) were studied in blood plasma and milk in two groups of six Istrian Pramenka dairy sheep and their suckling lambs following pour-on administration of EPR to ewes ... at dose levels of 0.5 and 1 mgžkg. Maximum concentration in plasma was 2.22 and 5.25 g/l, and AUC was 13.6 and 33.7 /g day/l for the 0.5 and 1.0 mg/kg dose, respectively. These results indicate that drug exposure with a dose of 0.5 mg/kg, which is commonly used in cattle, may be subtherapeutic. The concentration time course in milk paralleled plasma concentrations. In the dose range studied, linear pharmacokinetics of EPR were demonstrated. Milk-to-plasma AUC ratio was 0.790.12 and 1.12 0.43; the fraction of dose recovered in milk was 0.037 0.011% and 0.058 0.027% for the low and high dose, respectively. Maximum residual levels in milk were below the maximum acceptable level of 20 g/kg however, EPR was detected in all samples investigated. Despite low permeability in milk, AUC in plasma of suckling lambs was between 20 and 30% of the AUC in plasma of ewes.Source: Veterinary Parasitology. - ISSN 0304-4017 (Vol. 154, no. 1/2, 2008, str. 129-136)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 2269809
Author
Hodošček, Lena |
Grabnar, Iztok |
Milčinski, Luka |
Süssinger, Adica |
Kožuh Eržen, Nevenka |
Zadnik, Tomaž |
Pogačnik, Milan, 1946- |
Cerkvenik, Vesna
Topics
farmakokinetika |
eprinomektin |
ovce, istrske |
mleko
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hodošček, Lena | |
Grabnar, Iztok | 16107 |
Milčinski, Luka | 27779 |
Süssinger, Adica | 17558 |
Kožuh Eržen, Nevenka | 11780 |
Zadnik, Tomaž | 07171 |
Pogačnik, Milan, 1946- | 01644 |
Cerkvenik, Vesna | 08602 |
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