-
Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1betaStrle, Klemen ...Prolonged and excessive inflammation is implicated in resistance to the biological actions of IGF-I and contributes to the pathophysiology of neurodegenerative, metabolic, and muscle-wasting ... disorders. IL-10 is a critical anti-inflammatory cytokine that restrains inflammatory responses in macrophages and T cells by inhibiting cytokine and chemokine synthesis and reducing expression of their receptors. Here we demonstrate that IL-10 plays aprotective role in nonhematopoietic cells by suppressing the ability of exogenous IL-1beta to inhibit IGF-I-induced myogenin and myosin heavy chain expression in myoblasts. This action of IL-10 is not caused by impairment of IL-1beta-induced synthesis of IL-6 or the ability of IL-1beta to activate two members of the MAPK family, ERK1/2 and p38. Instead, this newly defined protective role of IL-10 occurs by specific reversal of IL-1beta activation ofthe JNK kinase pathway. IL-10 blocks IL-1beta-induced phosphorylation of JNK, but not ERK1/2 or p38, indicating that only the JNK component of the IL-1beta-induced MAPK signaling pathway is targeted by IL-10. This conclusion is supported by the finding that a specific JNK inhibitor acts similarly to IL-10 to restore IGF-I-induced myogenin expression, which is suppressed by IL-1beta. Collectively, these data demonstrate that IL-10 acts in a novel, nonclassical, protective manner in nonhematopoietic cells to inhibit the IL-1beta receptor-induced JNK kinase pathway, resulting in prevention of IGF-Iresistance.Source: American journal of physiology. endocrinology and metabolism. - ISSN 0193-1849 (Letn. 294, št. 4, 2008, str. E709-E718)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24186329
Author
Strle, Klemen |
McCusker, Robert H. |
Johnson, Rodney W. |
Zunich, Samantha M. |
Dantzer, Robert |
Kelley, Keith W.
Topics
Interleukin-10 |
Insulin-Like Growth Factor I |
Interleukin-1 |
Myogenin |
Interleukin-6 |
Myosin Heavy Chains |
Recombinant Proteins |
Antibodies, Monoclonal |
Muscle, Skeletal |
Cells, Cultured |
Interlevkin-6 |
Interlevkin-1 |
Interlevkin-10 |
Inzulin-podobeni, rastni faktor I |
Miogenin |
Mišica skeletna |
Protitelesa monoklonska |
Miozin težkih verig |
Rekombinantne beljakovine |
Celične kulture
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Strle, Klemen | 30270 |
McCusker, Robert H. | |
Johnson, Rodney W. | |
Zunich, Samantha M. | |
Dantzer, Robert | |
Kelley, Keith W. |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.