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Flavonoids, cinnamic acid derivatives as inhibitors of 17 ß-hydroxysteroid dehydrogenase type 1Brožič, Petra ...17ß-Hydroxysteroid dehydrogenase (17ß-HSD) type 1 converts estrone to estradiol, a potent ligand for estrogen receptors. It represents an important target for the development of drugs for treatment ... of estrogen-dependent diseases. In the present study, we have examined the inhibitory activities of some flavonoids, their biosynthetic precursors (cinnamic acids and coumaric acid), and their derivatives. The proliferative activity of flavonoids on the T-47D estrogen-receptor-positive breast cancer cell line was also evaluated. Among 10 flavonoids, 7,4ß-dihydroxyflavone, diosmetin, chrysoeriol, scutellarein, genkwanin and fisetin showed more than 70% inhibition of 17ß-HSDtype 1 at 6 ßM. In a series of 18 derivatives of cinnamic acid, the best inhibitor was 4ß-cyanophenyl 3,4-methylenedioxycinnamate, with more than 70% inhibition of 1717ß-HSD type 1. None of flavonoids affected the proliferation of T-47D breast cancer cells.Source: Pre-receptor steroid metabolism as target for pharmacological treatment : May 26-28, 2008, Grainau, Germany (issues 1/2, Vol. 301, 2009, str. 229-234)Type of material - conference contributionPublish date - 2009Language - englishCOBISS.SI-ID - 24720601
source: Pre-receptor steroid metabolism as target for pharmacological treatment : May 26-28, 2008, Grainau, Germany (issues 1/2, Vol. 301, 2009, str. 229-234)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Brožič, Petra | 27575 |
Kocbek, Petra, farmacevtka | 24402 |
Sova, Matej, 1979- | 25490 |
Kristl, Julijana | 09032 |
Martens, Stefan, biokemik | |
Adamski, Jerzy, molekularna biologija | 55378 |
Gobec, Stanislav, 1970- | 15284 |
Lanišnik-Rižner, Tea | 11699 |
Source: Personal bibliographies
and: SICRIS
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