ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Role of specific DNA mutations in the peripheral blood of colorectal cancer patients for the assessment of tumor stage and residual disease following tumor resectionNorčič, Gregor ...In the present study, the detection of tumor%specific KRAS proto%oncogene, GTPase (KRAS) and B%Raf proto%oncogene, serine/threonine kinase (BRAF) mutations in the peripheral blood of colorectal ... cancer (CRC) patients at all stages and adenomas was used for the estimation of disease stage prior to surgery and for residual disease following surgery. A total of 65 CRC patients were enrolled. The primary tumor tested positive for the specific mutations (KRAS mutations in codons 12, 13, 61, 117 or 146 and BRAF mutations in codon 600) in 35 patients. In all these patients, the specimen of normal bowel resected with the tumor was also tested for the presence of the same mutations in order to exclude the germ%line mutations. Only patients who tested positive for the specific mutation in the primary tumor were included in further analysis for the presence of tumor%specific mutation in the peripheral blood. No statistically significant differences were found between the detection rates of tumor mutations in the blood and different tumor stages (P=0.491). However, statistically significant differences in the proportions of patients with detected tumor%specific DNA mutations in the peripheral blood were found when comparing the groups of patients with R0 and R2 resections (P=0.038). Tumor%specific DNA mutations in the peripheral blood were more frequently detected in the patients with an incomplete surgical clearance of the tumor due to macroscopic residual disease (R2 resections). Therefore, the study concludes that the follow%up of somatic KRAS% and BRAF%mutated DNA in the peripheral blood of CRC patients may be useful in assessing the surgical clearance of the disease.Source: Oncology Letters. - ISSN 1792-1074 (Vol. 12, no. 5, 2016, str. 3356-3362)Type of material - article, component partPublish date - 2016Language - englishCOBISS.SI-ID - 2479483
Author
Norčič, Gregor |
Jelenc, Franc, 1948- |
Škerl, Petra, doktorica biologije |
Stegel, Petra |
Novaković, Srdjan
Topics
rak debelega črevesa in danke |
mutacije DNK |
onkogeni |
geni |
colorectal cancer |
KRAS |
BRAF |
CK20
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Norčič, Gregor | 28912 |
Jelenc, Franc, 1948- | 06758 |
Škerl, Petra, doktorica biologije | 28388 |
Stegel, Petra | |
Novaković, Srdjan | 08007 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: