ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Genetic polymorphisms in base excision repair in healthy Slovenian population and their influence on DNA damageErčulj, Nina ; Zadel, Maja ; Dolžan, VitaGenetic polymorphisms in DNA repair genes may result in altered DNA damage. The aim of our study was to determine the frequencies of common functional single nucleotide polymorphisms (SNPs) in ... specific base-excision DNA repair (BER) genes in healthy Slovenian population and evaluate their influence on DNA damage established by comet assay. In total 141 unrelated healthy subjectswere genotyped for hOGGl Ser326Cys, XRCCl Arg194Trp and Arg399Gln polymorphisms by real-time TaqMan assay. The frequencies of the hOGGl 326Ser/Ser, 326Ser/Cys and 326Cys/Cys genotypes were 63.8, 29.8, and 6.4%, respectively. The frequency distribution of XRCCl polymorphism was 88.7% for 194Arg/Arg, 9.2% for 194ArglTrp, 2.1 % for 194TrpITrp and 46.8% for 399Arg/Arg40.4% for 399Arg/Gln, 12.8% for 399Gln/Gln. The influence of selected BER polymorphisms on the percentage of comet tail DNA (% TD) was determined in a subgroup of 26 subjects. We found that% TD was significantly increased among individuals with hOGGl 326Ser/Cys heterozygous variant genotype as compared to 326SerlSer wild-type genotype (% TD = 8.9 4.2 vs. % TD = 6.9 1.4, P = 0.017). No significant associations between XRCCl Arg194Trp and Arg399Gln polymorphisms and% TD were found. Our results confirmed that DNA damage is modulated by hOGGl Ser326Cys polymorphism.Source: Acta chimica slovenica. - ISSN 1318-0207 (Letn. 57, št. 1, 2010, str. 182-188)Type of material - article, component partPublish date - 2010Language - englishCOBISS.SI-ID - 26765785
Author
Erčulj, Nina |
Zadel, Maja |
Dolžan, Vita
Topics
Dna Damage |
Genotype |
Polymorphism (Genetics) |
Dna Repair |
DNA, pošdkoba |
Polimorfizem (genetika) |
Genotip |
DNA, obnova
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Erčulj, Nina | 30705 |
Zadel, Maja | 34112 |
Dolžan, Vita | 11711 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: