-
A closed literature-based discovery technique finds a mechanistic link between hypogonadism and diminished sleep quality in aging menMiller, Christopher M. ...STUDY OBJECTIVES: Sleep quality commonly diminishes with age, and, further, aging men often exhibit a wider range of sleep pathologies than women. We useda freely available, web-based discovery ... technique (Semantic MEDLINE) supported by semantic relationships to automatically extract information from MEDLINE titles and abstracts. DESIGN: We assumed that testosterone is associated with sleep (the A-C relationship in the paradigm) and looked for a mechanism to explain this association (B explanatory link) as a potential or partial mechanism underpinning the etiology of eroded sleep quality in aging men. MEASUREMENTS AND RESULTS: Review of full-text papers in critical nodes discovered in this manner resulted in the proposal that testosterone enhances sleep by inhibiting cortisol. Using this discovery method, we posit, and couldconfirm as a novel hypothesis, cortisol as part of a mechanistic link elucidating the observed correlation between decreased testosterone in aging men and diminished sleep quality. CONCLUSIONS: This approach is publically available and useful not only in this manner but also to generate from the literature alternative explanatory models for observed experimental results.Source: Sleep. - ISSN 0161-8105 (Vol. 35, no. 2, 2012, str. 279-285)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 29619673
Author
Miller, Christopher M. |
Rindflesch, Thomas C. |
Fiszman, Marcelo |
Hristovski, Dimitar, 1964- |
Shin, Dongwook |
Rosemblat, Graciela |
Zhang, Han |
Strohl, Kingman P.
Topics
Hypogonadism |
Sleep Disorders |
Aging |
Testosterone |
Information Storage And Retrieval |
Cortisone |
Medline |
Hipogonadizem |
Staranje |
Testosteron |
Spanje, motnje |
Shranjevanje in iskanje informacij |
Kortizon |
MEDLINE
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Miller, Christopher M. | |
Rindflesch, Thomas C. | |
Fiszman, Marcelo | |
Hristovski, Dimitar, 1964- | 11373 |
Shin, Dongwook | |
Rosemblat, Graciela | |
Zhang, Han | |
Strohl, Kingman P. |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.