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The influence of microemulsion structure on their skin irritation and phototoxicity potentialRozman, Branka ...The purpose of this study was to examine skin irritation and phototoxicity potentials of several microemulsions (ME), all comprising approximately the same percentage of surfactant mixture, but ... varying oil/water content and consequently inner structure being either droplet-like (o/w ME, o/w ME carbomer, w/o ME and w/o ME white wax) or lamellar (gel-like ME). Two different in vitro methods were used: MTT assay (performed either on reconstructed human epidermis (RHE) or NCTC 2544 cells) and pig ear test. Neither assay revealed the difference among ME with droplet-like structure. Then again, pig ear test and MTT assay performed on RHE indicated that gel-like ME is more irritant compared to other tested ME, whereas no difference among formulations were observed by MTT assay on NCTC 2544 cells. The reasonable explanation is destruction and consequently uniform structure of ME upon dilution that is inevitable for testing on cell cultures. The results of phototoxicity test again indicated the increased potential of gel-like ME to cause adverse effects on skin. It can be concluded that for ME consisting of the same amount of identical surfactants but having different structure the latter represent a crucial factor that determines their dermal toxicity.Source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 499, iss. 1-2, 2016, str. 228-235)Type of material - article, component part ; adult, seriousPublish date - 2016Language - englishCOBISS.SI-ID - 4013425
Author
Rozman, Branka |
Gosenca Matjaž, Mirjam |
Falson, Françoise |
Gašperlin, Mirjana
Topics
microemulsion |
structure |
skin irritation |
RHE |
keratinocyte cell cultures |
phototoxicity
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source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 499, iss. 1-2, 2016, str. 228-235)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rozman, Branka | 25488 |
Gosenca Matjaž, Mirjam | 29887 |
Falson, Françoise | ![]() |
Gašperlin, Mirjana | 11789 |
Source: Personal bibliographies
and: SICRIS
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