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  • Development of multi-residue analysis of pharmaceuticals in water samples by stir-bar sorptive extraction using liquid chromatography-mass spectrometry [Elektronski vir]
    Klančar, Anita, farmacevtka ; Trontelj, Jurij ; Roškar, Robert, 1975-
    The present study covered the development of stir-bar sorptive extraction process and the new rapid analytical LC-MS/MS method for target pharmaceutical compounds determination. A list of 15 ... representative pharmaceuticals from a wide range of therapeutic classes was selected according to their chemical properties, in particular the octanol-water partition coefficient (2.7 <- log KO/W <- 5.2). First, extraction conditions, such as time, temperature and solvent of extraction and desorption, addition of NaCl and MeOH were evaluated. The optimized extraction method provided remarkable recoveries (55-101 %) and a wide linear range (mainly 1.25-1250 ng/L, R2 >0.99) with very low limit of detection for all analytes (1.25 ng/L). The proposed method enables a rapid and simple extraction process, what result in high throughput and less workload per sample. Consequently, it is highly suitable to be involved in routine monitoring of particular pharmaceuticals in various environmental water samples.
    Source: Conference proceedings [Elektronski vir] (2 str.)
    Type of material - conference contribution
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 4202865

    Link(s):

    http://www.susana.org/en/events/calendar/details/83

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