Faculty of Pharmacy, Lj. (FFALJ)
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Razvoj populacijskega farmakokinetičnega modela takrolimusa pri bolnikih po presaditvi pljuč = Development of a tacrolimus population pharmacokinetic model in patients after lung transplantation : magistrska nalogaŠehić, SanelaPreživetje bolnikov po presaditvi pljuč ima bistveno slabšo prognozo v primerjavi s transplantacijami drugih trdnih organov, k čemur, poleg edinstvenih fizioloških značilnosti pljuč, prispeva težavno ... odmerjanje imunosupresivov zaradi njihove velike farmakokinetične variabilnosti. Namen te magistrske naloge je bil ovrednotiti, kako dobro obstoječi literaturni populacijski farmakokinetični modeli za takrolimus po transplantaciji pljuč opišejo izmerjene koncentracije takrolimusa pri preiskovani populaciji pacientov. Raziskali smo tudi vplive biokemičnih, genetskih in kliničnih dejavnikov na variabilnost farmakokinetike takrolimusa, opredelili njihovo statistično značilnost ter razvili končni populacijski farmakokinetični model, ki vključuje vse značilne vplive sočasnih spremenljivk. Končni model je dvoprostorni z naslednjimi vrednostmi parametrov in njihovimi interindividualnimi variabilnostmi (IIV): ktr = 6,97 h–1 (41,1 %), CL/F = 11,4 L/h (35,6 %), V1/F = 126 L (46,4 %), V2/F = 569 L (200 %), Q/F = 41,2 L/h (70,0 %), z vključenim vplivom naslednjih sočasnih spremenljivk na očistek: čas po transplantaciji (TAT), hematokrit, serumska koncentracija kreatinina, serumska koncentracija proteinov, sočasno zdravlje z posakonazolom, vorikonazolom, metronidazolom ali flukonazolom, sočasno zdravljenje s klaritromicinom ter sočasno zdravljenje s testosteronom. Izdelan populacijski farmakokinetični model lahko prispeva k optimizaciji režimov odmerjanja takrolimusa po transplantaciji pljuč.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [S. Šehić], 2022Language - slovenianCOBISS.SI-ID - 132863491
Author
Šehić, Sanela
Other authors
Grabnar, Iztok |
Bürmen, Božena
Topics
Transplantacija |
Imunosupresivna biološka zdravila |
presaditev pljuč |
takrolimus |
populacijski farmakokinetični model |
NONMEM |
nelinearno modeliranje mešanih učinkov
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Knjižnica emšf 615.3 ŠEHIĆ SANELA Razvoj 0000001177 IN: 0017494 Knjižnica emšf 615.3 ŠEHIĆ SANELA Razvoj 1177 IN: 0017494 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Šehić, Sanela | |
Grabnar, Iztok | 16107 |
Bürmen, Božena | 55473 |
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