Faculty of Pharmacy, Lj. (FFALJ)
-
Računalniška analiza primernosti encima MurC za načrtovanje novih protibakterijskih učinkovin = Computational analysis of the MurC enzyme suitability for the design of new antibacterial agents : enoviti magistrski študijski program FarmacijaČerne, Anja, farmacevtkaBakterijska odpornost na trenutno dostopna antibiotična zdravila je eden največjih problemov javnega zdravja. K njenemu pojavu prispevata neustrezna in/ali prekomerna uporaba antibiotikov ter upadel ... razvoj novih antibiotičnih zdravil v zadnjih letih. Zato je razvoj novih protibakterijskih učinkovin nujen, pri čemer ga je smiselno usmeriti na mehanizme, ki so za obstoj bakterij nujni, kot sta na primer proces celične delitve ali biosinteza bakterijskega peptidoglikana. Eden izmed encimov, ki igrajo ključno vlogo pri biosintezi peptidoglikana, je encim UDP-N-acetilmuramat-L-alanin ligaza ali MurC. V okviru magistrske naloge smo zato s pomočjo različnih bioinformacijskih orodij, podatkovnih baz in programov poskušali ugotoviti, ali je encim MurC primerna tarča za razvoj novih protibakterijskih učinkovin. Pri analizi encima smo se osredotočili na ključne lastnosti potencialne tarče, kot so esencialnost gena, evolucijska ohranjenost aminokislin in sposobnost za vezavo učinkovine. Ugotovili smo, da je encim MurC esencialen za 43 bakterijskih organizmov, od katerih so trije organizmi ESKAPE. S pomočjo spletnega orodja UniProt smo ugotovili, da je izmed bakterij, pri katerih je znana sekvenca encima MurC, 11,7 % patogenih. S pomočjo analize evolucijske ohranjenosti aminokislin, poizvedb o napovedi potencialnih vezavnih mest in poizvedb o interakcijah aminokislin smo identificirali osem aminokislinskih položajev, ki so najprimernejši za tarčno ciljanje z učinkovino. Ti aminokislinski položaji encima MurC so: 128, 129, 130, 131, 173, 326, 346 in 352.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [A. Černe], 2023Language - slovenianCOBISS.SI-ID - 141789699
Author
Černe, Anja, farmacevtka
Other authors
Frlan, Rok
Topics
Bakterijska rezistenca |
MurC |
evolucijska ohranjenost |
esencialnost |
bioinformacijska orodja |
antibiotična zdravila
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Call number – location, accession no. ... |
Copy status | Reservation |
---|---|---|
Knjižnica emšf 0000000615 ČERNE ANJA Računal 0000001227 IN: 0017594 Knjižnica emšf 615 ČERNE ANJA Računal 1227 IN: 0017594 |
available - reading room
|
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Černe, Anja, farmacevtka | ![]() |
Frlan, Rok | 26512 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: