Razvoj metod za napovedovanje koloidne stabilnosti visokokoncentriranih formulacij z monoklonskimi protitelesi = Development of methods for predicting the colloidal stability of highly concentrated formulations containing monoclonal antibodies : magistrska naloga : magistrski študijski program Industrijska farmacija
Müller, Ana, farmacevtka
V sklopu magistrske naloge smo z uporabo napovednih parametrov difuzijskega interakcijskega parametra kD in drugega virialnega koeficienta B22 ter tudi preko zeta potenciala sklepali na koloidno ...stabilnost visokokoncentriranih formulacij z monoklonskimi protitelesi. Ovrednotili smo vpliv sestave formulacije in vpliv kemijske ter temperaturne obremenitve na koloidno stabilnost formulacij z mAb, pri čemer smo le-te izpostavili različnim stresnim pogojem: dodatku vodikovega peroksida, dodatku kislin in/ali baze, dodatku železovih ionov ter povišani temperaturi. Vsi stresni dejavniki so oslabili koloidno stabilnost proteina. Parametra kD in B22 smo ocenili kot ustrezna indikatorja koloidne stabilnosti.
Type of material - master's thesis
; adult, serious
Publication and manufacture - Ljubljana : [A. Müller], 2023
Knjižnica mind 0000000661 MÜLLER ANA Razvoj 0000000268 IN: 0017597
Knjižnica mind 661 MÜLLER ANA Razvoj 268 IN: 0017597
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