Etiologija in patofiziologija revmatoidnega artritisa = Ethiology and patophysiology of rheumatoid arthritis
Ihan, Alojz
Za vnetje pro revmatoidnem artritisu je znaèilna sinteza topnih mediatorjev, ki povzroèijo unièevanje sklepnega hrustanca in kostnine. Vzrok za nastanek RAni znan, stevilne dokazi pa kazejo na ...poglavitno vlogo celic T pomagalk (CD4+) pri patogenezi bolezni. Med antigeni, ki naj bi sprozili aktivacijo celic T pomagalk, se najpogosteje omenjajo sklepni antigeni (napr. kolagen II), vendar rezultati niso zanesljivi. Novejse metode (napr. MHC-tetramerni reagenti) naj bi dali jasnejsi odgovor tem. Bolje kot sprozilni antigeni so opredeljeni mehanizmi unièevanja sklepa, ki sledijo aktivaciji celic T pomagalk. TNF alfa in IL1 beta sta poglavitna mediatorja vnetja pri RA. TNF alfa stimulira celice, ki tvorijo vnetne mediatorje (citokine, metaloproteaze,NO, PGE2.), IL1 beta pa povzroèa destrukcijo hrustanca in kostnine (prek izloèanja metaloproteaz, zmanjsane sinteze glikozaminoglikanov.). Velik napredek pri zdravljenju RA so pvzroèilabioloska zdravila, ki inhibirajo delovanje TNF alfa in IL1 beta. Tudi citokini, ki sodelujejo v vnetni kaskadi pred TNF alfa in IL1 beta (napr IL18) so laho tarèa terapevtske inhibicije. Tudi citokini s protivnetnim uèinkom (IL4. IL10,IL13) bi lahko bili uèinkoviti pri zdravljenju RA.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
