Faculty of Pharmacy, Lj. (FFALJ)
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Sistem CRISPR/Cas9 in njegova uporaba v genetskem inženirstvu = The CRISPR/Cas9 system and its applications in genetic engineeringSrpčič, Anja, farmacevtka ; Lovšin, NikaSistem CRISPR/Cas9 je nedavno odkrit pridobljeni bakterijski imunski odziv proti virusom in tujim DNA, ki vstopajo v bakterijsko celico. Sistem CRISPR/Cas9 tujo DNA po vstopu v bakterijsko celico ... prepozna in jo razgradi. Pri tem del tuje DNA vključi v lasten genom, tako da ostane »spomin« na tujo DNA, ki omogoča hitro prepoznavo in razgradnjo pri vnovični okužbi. Bistvo sistema je prepoznavanje kratkih zaporedij tuje DNA s pomočjo vezave na komplementarno kratko zaporedje RNA in endonukleazo Cas9, ki po prepoznavi in vezavi tujo DNA razgradi. Z odkritjem tega imunskega sistema bakterij so se pojavile široke možnosti za njegovo uporabo v biotehnološke namene. V zadnjem desetletju so razvili metode za izbijanje, utišanje in aktivacijo praktično katerega koli gena v katerem koli organizmu. Sistem CRISPR/Cas9 omogoča hitro, učinkovito in specifično spreminjanje genoma. V preglednem članku predstavljamo mehanizem delovanja imunskega odziva bakterij CRISPR/Cas9 in možnosti uporabe v biotehnološke in biomedicinske namene.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 74, št. 3, 2023, str. 205-214)Type of material - article, component part ; adult, seriousPublish date - 2023Language - slovenianCOBISS.SI-ID - 160756739
Author
Srpčič, Anja, farmacevtka |
Lovšin, Nika
Topics
Imunski odziv |
Genetski inženiring |
CRISPR/Cas9 |
genetsko urejanje |
genska terapija |
izbijanje genov
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 74, št. 3, 2023, str. 205-214)
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Database name | Field | Year |
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Srpčič, Anja, farmacevtka | 57036 |
Lovšin, Nika | 19649 |
Source: Personal bibliographies
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