Faculty of Pharmacy, Lj. (FFALJ)
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Sinteza in vrednotenje fluorescenčnih sond iz skupine merocianinov za označevanje lipofilnih struktur = Synthesis and evaluation of merocyanine-based fluorescent probes for labelling of lipophilic structures : študijski program industrijska farmacijaBijek, KlavdijaFluorescenca je pojav, pri katerem zaradi svetlobnega ali elektromagnetnega dražljaja pride do vzbuditve elektrona, ki preide iz osnovnega v vzbujeno stanje. Pri prehodu nazaj v osnovno stanje ta ... odda svetlobo daljše valovne dolžine kot jo je absorbiral, kar se odraža v obliki fluorescence spojine. Proces vzbujanja in emisije je lažje predstaviti z Jablonskim diagramom, ki s puščicami prikazuje prehode med posameznimi elektronskimi stanji in tudi znotraj njih. Spojine, ki so sposobne opraviti elektronske prehode in posledično fluorescirati imenujemo fluorofori. Mednje spadajo kumarini in tudi njihova podvrsta merocianini. Zanje je značilna prisotnost aromatskih obročev in karbonilne skupine. Oboji omogočajo številne modifikacije strukture z vezavo različnih substituent, kar pa lahko vpliva tudi na izboljšanje ali poslabšanje fluorescence. V sklopu magistrske naloge smo sintetizirali spojine iz skupine merocianinov. Gre za pomembno skupino fluorescentnih barvil, ki se uporabljajo pri raziskovanju celičnih struktur s pomočjo fluorescenčne mikroskopije, s čimer lahko odkrijemo biokemijsko ozadje patološki stanj. Na podlagi tega lahko vršimo učinkovit razvoj novih, predvsem pa učinkovitih zdravilnih učinkovin. Pri sintetiziranju smo si za potrditev strukture željenih spojin pomagali z NMR spektroskopijo. Uspešno smo sintetizirali štiri spojine in sicer 10(1), 10(2), 12 in 9. Trem smo posneli absorpcijske in emisijske spektre in jim pomerili fluorescenco. Uporabili smo jih tudi za analizo s fluorescenčno mikroskopijo, s čimer smo ovrednotili njihovo ustreznost za označevanje lipofilnih struktur. Ugotovili smo, da so vse spojine primerne za STED mikroskopijo, da so malo okoljsko občutljive na pogoje v okolju molekule in da so fotostabilne, s čimer smo potrdili njihovo ustreznost za namene označevanja celic.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [K. Bijek], 2023Language - slovenianCOBISS.SI-ID - 178629123
Author
Bijek, Klavdija
Other authors
Pajk, Stane, 1983- |
Kokot, Hana
Topics
Analizna kemija |
fluorescenca |
fluorofor |
lipofilne strukture |
STED mikroskopija |
merocianin
Call number – location, accession no. ... |
Copy status | Reservation |
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Knjižnica mind 0000000543 BIJEK KLAVDIJA Sinteza 0000000305 IN: 0017953 Knjižnica mind 543 BIJEK KLAVDIJA Sinteza 305 IN: 0017953 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bijek, Klavdija | |
Pajk, Stane, 1983- | 28861 |
Kokot, Hana | 38855 |
Source: Personal bibliographies
and: SICRIS
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