Faculty of Pharmacy, Lj. (FFALJ)
-
Population pharmacokinetics of ramipril in patients with chronic heart failure [Elektronski vir] : a real-world longitudinal studyTrobec, Katja ...In patients with chronic heart failure (CHF), the use of angiotensinconverting enzyme inhibitors, including ramipril, is recommended to reduce the risk of heart failure worsening, hospitalisation, ... and death. Our aim was to investigate the influence of body composition on the pharmacokinetics of ramipril and its active metabolite ramiprilat and to evaluate the changes in pharmacokinetics after prolonged therapy. Twenty-three patients with CHF who were on regular therapy with ramipril participated at the first study visit (median age 77 years, 65 % male, and 70 % New York Heart Association Class II); 19 patients attended the second study visit and the median time between the two visits was 8 months. Pharmacokinetics were assessed using a nonlinear mixed-effects parent-metabolite model comprising two compartments for ramipril and one compartment for ramiprilat. The influence of body size and composition was best described by an allometric relationship with fat-free mass. In addition, ramipril clearance was related to patient age and daily ramipril dose, while clearance of ramiprilat was influenced by glomerular filtration rate and daily ramipril dose. There were no clinically relevant changes in the pharmacokinetics of ramipril and ramiprilat between the study visits. Due to the relatively stable pharmacokinetics of ramipril, regular outpatient visits at 6-month intervals seem appropriate to evaluate ramipril therapy.Source: Acta pharmaceutica. - ISSN 1846-9558 (Vol. 74, no. 2, 2024, str. 315-328)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 194982915
Author
Trobec, Katja |
Grabnar, Iztok |
Trontelj, Jurij |
Lainščak, Mitja |
Kerec Kos, Mojca
Topics
Farmakokinetika |
NUK |
Srčno popuščanje |
ramipril |
ramiprilat |
pharmacokinetics |
chronic heart failure |
body composition |
ramipril |
ramiprilat |
kronično srčno popuščanje |
telesna sestava
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Author | Trobec, Katja ... |
Title | Population pharmacokinetics of ramipril in patients with chronic heart failure [Elektronski vir] : a real-world longitudinal study |
Publication date | |
COBISS.SI-ID | 194982915 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
---|
![]() |
![]() |
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Trobec, Katja | 33191 |
Grabnar, Iztok | 16107 |
Trontelj, Jurij | 23420 |
Lainščak, Mitja | 22680 |
Kerec Kos, Mojca | 20370 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: