Faculty of Pharmacy, Lj. (FFALJ)
-
Imunska modulacija vnetne celične komponente v eksperimentalnem modelu postopka zunajtelesne fototerapije = Immune modulation of proinflammatory cell component in experimental model of extracorporeal phototherapy : Uniform Master's Study Programme PharmacyCajhen, AnjaZunajtelesna fototerapija je celična imunoterapija, ki na imunski sistem deluje tako zaviralno kot spodbujevalno, kar omogoča njeno uporabo pri zdravljenju bolezni presadka proti gostitelju in ... kožnega T-celičnega limfoma. Postopek ECP se izvede v treh stopnjah: odvzem mononuklearnih celic z aferezo, obdelava zbranih celic z 8-metoksipsoralenom in UVA svetlobo, ki sproži apoptozo celic ter ponovno injiciranje obdelanih celic v pacientov krvni obtok. Tako obdelane celice v postopku zunajtelesne fototerapije predstavljajo zdravilo, natančneje napredno celično zdravilo. Med pripravo celičnega zdravila oz. celičnega produkta se ustvarijo imunozaviralne in imunospodbujevalne oz. vnetne celične komponente. Slednje predstavljajo med postopkom zunajtelesne fototerapije aktivirani monociti, ki v telesu kot zrele dendritične celice inducirajo nastanek efektorskih imunskih odzivov. Naš namen je bil razviti standardiziran protokol za in vitro tretiranje celic s spojinami, ki inhibirajo aktivacijo monocitov, in s tem narediti prvi korak k optimizaciji zunajtelesne fototerapije za zdravljenje bolezni presadka proti gostitelju. Vrednotili smo učinek deksametazona na diferenciacijo in zorenje monocitov v kulturi MNC, izoliranih iz krvi prostovoljnih zdravih krvodajalcev. Mononuklearne celice smo z 28 do 558 %g/ml deksametazona tretirali 24 oz. 48 ur. Nato smo jih 24 ur aktivirali z različnimi stimulansi: LPS (1 %l/ml), LPS (1 %l/ml) + IFN% (0,5 %l/ml), mCD40L (2 %l/ml), mCD40L (2 %l/ml) + IFN% (0,5 %l/ml) in R848 (1 %l/ml). Kot ustrezna stimulansa za uporabo v našem eksperimentalnem modelu sta se izkazala le LPS+IFN% in R848, saj z ostalimi nismo pridobili ustrezne pozitivne kontrole. Celice, tretirane z deksametazonom, so izražale nižjo raven ko-stimulacijskih molekul CD40, CD80, CD83 in CD86 kot netretirane celice. Do upada izražanja ko-stimulacijskih molekul na tretiranih monocitih v primerjavi z netretiranimi monociti je prišlo tudi po aktivaciji z LPS+IFN%. Učinka deksametazona na izražanje inhibitornih molekul ILT-3, ILT-4 in PD-L1 zaradi slabe ponovljivosti nismo uspeli ugotoviti. Po aktivaciji z LPS+IFN% ali R848 se je zmanjšala kapaciteta izločanja vnetnih citokinov IL-8, IL-1%, IL-6, TNF%, IL-12p70 in protivnetnega citokina IL-10 iz monocitov tretiranih z deksametazonom. Rezultati naših poskusov torej kažejo, da dekametazon delno inhibira diferenciacijo in zorenje monocitov.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [A. Cajhen], 2019Language - slovenianCOBISS.SI-ID - 4671601
Author
Cajhen, Anja
Other authors
Švajger, Urban
Topics
Fototerapija |
deksametazon |
monociti |
ko-stimulacijske molekule |
zunajtelesna fototerapija |
bolezen presadka proti gostitelju
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Call number – location, accession no. ... |
Copy status | Reservation |
---|---|---|
Knjižnica emšf 0000000615 CAJHEN ANJA Imunska 0000000679 IN: 0016075 Knjižnica emšf 615 CAJHEN ANJA Imunska 679 IN: 0016075 |
available - reading room
|
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Cajhen, Anja | ![]() |
Švajger, Urban | 26198 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: