Faculty of Pharmacy, Lj. (FFALJ)
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Influence of lipid-lowering drugs on inflammation: what is yet to be done? [Elektronski vir]Ugovšek, Sabina ...Atherosclerosis is a chronic inflammatory disease that is associated with risk of cardiovascular events. The best-characterised and well-standardised clinical indicator of inflammation is C-reactive ... protein. Current evidence-based drug therapies for prevention and treatment of cardiovascular diseases are mainly focused on reduction of low-density lipoprotein cholesterol. However, these drugs do not provide sufficient protection against recurrent cardiovascular events. One of the possible mechanisms behind this recurrence might be the persistence of residual inflammation. For the most commonly used lipid-lowering drugs, the statins, their reduction of cardiovascular events goes beyond lowering of low-density lipoprotein cholesterol. Here, we review the effects of these lipid-lowering drugs on inflammation, in terms of statins, ezetimibe, fibrates, niacin, proprotein convertase subtilisin/kexin type 9 inhibitors, bempedoic acid, ethyl eicosapentaenoic acid and antisense oligonucleotides. We focus in particular on C-reactive protein, and discuss how the effects of the statins might be related to reduced rates of cardiovascular events.Source: Archives of Medical Science [Elektronski vir]. - ISSN 1896-9151 (Vol. 18, iss. 4, 2021, str. 855-869)Type of material - e-article ; adult, seriousPublish date - 2021Language - englishCOBISS.SI-ID - 66151683
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| Database name | Field | Year |
|---|
| Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
|---|---|
| Ugovšek, Sabina |  |
| Zupan, Janja, farmacevtka | 32306 |
| Rehberger Likozar, Andreja | |
| Šebeštjen, Miran | 19345 |
Source: Personal bibliographies
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