Ugotavljanje kromosomskih sprememb somatskih celic po obsevanju z ionizirajočimi žarki in zdravljenju s citostatiki pri bolnikih s tumorjem moda in malignim limfomom : doktorsko delo
Bilban-Jakopin, Cvetka
The incidences of testicular tumours and malignant lymphoma in Slovenia are onan increase. The average age of patients with testicular tumours and Hodgkinćs disease is most frequently between 15 and ...35. In most cases, treatment is standard and prognosis mainly favourable, especially if the disease is not widely spread Both types of malignant neoplasms are treated by ionising radiation and cytostatic drugs. The objective of treatment of oncological patients is cure or the longest possible survival with fewest possible side effects. However, ionising radiation and cytostatic drugs, when administered simultaneously or in succession, inevitably have undesired consequences. Their effects are visible in other cells and tissues as well, not only in malignant ones, while the objective of treatment is to stop cell division only in malignant cells. The consequences of permanent changes in thegenome certainly carry the greatest risk, since they can be the basis of a new malignant disease or carcinogenic and teratogenic effects resulting in intrauterine malformations. Lymphocytes in peripheral blood are the cell modelof choice for the determination of changes concerning the effect of treatment on the cell genome, as well as for establishing the improvement in the genome of patients. Lymphocytes with their dynamics of movement through vascular and extravascular compartments in the body are travelling indicators and microdosimeters, both for ionising radiation and for exposure to cytostatic drugs. This prospective study included 90 patients. With respect todiagnosis and the method of treatment (surgery, radiotherapy, chemotherapy or combination of these three methods), they were divided into six groups. Theresults for their genomes prior to the beginning of treatment, immediately after treatment and six months later were compared. An appropriate control group was selected. (Abstract truncated at 2000 characters).
Type of material - dissertation
; adult, serious
Publication and manufacture - Ljubljana : [C. Bilban-Jakopin], 2000
GS II 0000522715 glavno skladišče
GS II 522715 glavno skladišče
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