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Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approachZupančič, Klemen, 1985- ...Background. Glioblastoma multiforme (GBM) is a brain tumour with a very high patient mortality rate, with a median survival of 47 weeks. This might be improved by the identification of novel ... diagnostic, prognostic and predictive therapy-response biomarkers, preferentially through the monitoring of the patient blood. The aim of this study was to define the impact of GBM in terms of alterations of the plasma protein levels in these patients. Materials and methods. We used a commercially available antibody array that includes 656 antibodies to analyse blood plasma samples from 17 healthy volunteers in comparison with 17 blood plasma samples from patients with GBM. Results. We identified 11 plasma proteins that are statistically most strongly associated with the presence of GBM. These proteins belong to three functional signalling pathways: T-cell signalling and immune responses; cell adhesion and migration; and cell-cycle control and apoptosis. Thus, we can consider this identified set of proteins as potential diagnostic biomarker candidates for GBM. In addition, a set of 16 plasma proteins were significantly associated with the overall survival of these patients with GBM. Guanine nucleotide binding protein alpha (GNAO1) was associated with both GBM presence and survival of patients with GBM. Conclusions. Antibody array analysis represents a useful tool for the screening of plasma samples for potential cancer biomarker candidates in small-scale exploratory experiments; however, clinical validation of these candidates requires their further evaluation in a larger study on an independent cohort of patients.Source: Radiology and oncology. - ISSN 1318-2099 (Vol. 48, no. 3, Sep. 2014, str. 257-266, III)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 31525081
Author
Zupančič, Klemen, 1985- |
Blejec, Andrej |
Herman, Ana, farmacevtka |
Veber, Matija, biotehnologija, 1987- |
Verbovšek, Urška, 1985- |
Koršič, Marjan |
Knežević, Miomir |
Rožman, Primož, 1954- |
Lah Turnšek, Tamara |
Gruden, Kristina |
Motaln, Helena
Topics
glioblastoma |
proteomics |
biomarker |
glioblastom |
proteomika |
biomarker
Author | Zupančič, Klemen, 1985- ... |
Title | Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach |
Publication date | 2014-12-04 |
COBISS.SI-ID | 31525081 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Ekotoksiologija, toksikološka genomika in karcinogeneza | P1-0245-2009 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Zupančič, Klemen, 1985- | 34258 |
Blejec, Andrej | 06989 |
Herman, Ana, farmacevtka | 31225 |
Veber, Matija, biotehnologija, 1987- | 34653 |
Verbovšek, Urška, 1985- | 32811 |
Koršič, Marjan | 27916 |
Knežević, Miomir | 10038 |
Rožman, Primož, 1954- | 12336 |
Lah Turnšek, Tamara | 07802 |
Gruden, Kristina | 12688 |
Motaln, Helena | 21397 |
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