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Sodobno zdravljenje kroničnega hepatitisa B = Modern therapy for chronic hepatitis BBrinovec, Vladimir ; Lešničar, GorazdBolnike s kroničnim hepatitisom B v Sloveniji že več kot deset let zdravimo z interferonom alfa. Do leta 1988 smo v Sloveniji zdravili le simptomatsko, v posameznih primerih tudi s kortikosteroidi. V ... zadnjem času se za zdravljenje vse bolj uveljavljajo lamivudin, pa tudi famciklovir, adenovir in drugi nukleozidni analogi. Kljub pojavu odpornosti na nukleozidne analoge (YMDD-mutacije), zlasti lamivudin uspešno uporabljajo tudi pri zdravljenju bolnikov z dekompenzirano jetrno cirozo zaradi hepatitisa B. V kombinaciji s specifičnimi imunoglobulini proti hepatitisu B uporabljajo lamivudin tudi za zdravljenje bolnikov s kroničnim hepatitisom B s presajenimi jetri, kroničnih bolnikov s hepatitisom B, sočasno okuženih z virusom hepatitisa C ali/in hepatitisom D ali s HIV. Lamivudin se je izkazal tudi pri zdravljenju kronično okuženih otrok z virusom hepatitisa B, bolnikov z znaki okužbe s hepatitisom B zunaj jeter (poliartritis nodosa, glumerulonefritis), kroničnih bolnikov s hepatitisom B, ki so na kemoterapiji ter pri preprečevanju obporodne in tudi bolnišnične okužbe pri visoko viremičnih zdravstvenih delavcih. V prihodnosti dosti obeta kombinirano zdravljenje z nukleozidnimi analogi in pegiliranim interferonom.Source: Infektološki simpozij 2002 : zbornik predavanj (Let. 41, št. suppl. 2, 2002, str. 113-122)Type of material - conference contribution ; adult, seriousPublish date - 2002Language - slovenianCOBISS.SI-ID - 131491
Author
Brinovec, Vladimir |
Lešničar, Gorazd
Topics
Hepatitis B, chronic |
Drug therapy |
Congresses |
Hepatitis B, kronični |
Zdravljenje z zdravili |
Posvetovanja
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Database name | Field | Year |
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Brinovec, Vladimir | 03982 |
Lešničar, Gorazd | 14096 |
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