现行指南建议对ALT升高和HBV DNA 阳性慢性乙型肝炎(CHB)患者给予抗病毒治疗.但越来越多的研究表明,血清高正常ALT(0.5～1 倍正常值上限)慢性HBV感染者的肝组织可见显著坏死炎症和/或纤维化,并存在进展性肝病如肝硬化、肝细胞癌、乙型肝炎相关并发症甚至死亡的风险.本文讨论了血清高正常ALT的定义、血清高正常ALT慢性乙型肝炎患者的临床和病毒学特点,以及对此类患者应否启动抗病毒治疗.
碩士
國立宜蘭大學
生物技術研究所碩士班
97
Since the injection administration as the peptides and proteins delivery system, it imposes discomfort and inconvenience on patients, particularly for a long-term treatment. ...Therefore, the goal of this thesis is to find out an oral delivery system for improving the absorption of therapeutic protein drugs.
Emulsion is one of strategies known delivery vehicles for those oral medicines. Water-in-oil -in-water (W/O/W) multiple emulsion has been known to be possible to protect protein drugs from enzyme degradation and enhance the absorption of hydrophilic drugs to systemic circulation. Therefore, we tried to use granulocyte colony-stimulating factor (G-CSF) as the indicator to test the emulsion formulation for the oral delivery system in the study.
In this two-step emulsification procedure, the data of the droplet size (2 μm of diameter), encapsulation efficiency (40±5%), stability (at pH 1.2 for 2 hrs and 60°C for 5 days), permeability (into Caco-2 cell monolayer with 30 min) and in vitro
碩士
輔仁大學
博物館學研究所碩士班
101
The purpose of this study is to explore the learning interaction of children participating in hands-on educational activities. After literature reviews, a fossil digging ...activity was chosen to be the case study, the field site at National Taiwan Museum, and children visitors as the main research participants.
Based on field observation, a detailed record of the children’s individual participation and interaction between their peers were documented. The children’s own personal accounts were recorded as well after interacting with the activity. 20 participants were collected using purposive sampling, after the analysis of the data and literature reviews, the conclusion is as follows:
As the children participate with hands-on activities, adults help children by providing them with a variety of learning methods. In the learning process, adults often give children learning cues and guidance with questions. This encourages the children to interact with their peers as well as individually expl
碩士
國立屏東科技大學
企業管理系所
98
There are some articles examining business aesthetics today. However, few could provide a complete picture of its development and context. Generally, organizations would do ...their best to make profits. It does not mean that organizations would disregard their social value and ethic standards. It is claimed that business aesthetics could positively influence managers’ mind and thus increase organizational performance. Therefore, the aim of this research is to conceptualize the context of business aesthetics from (1) theology and philosophy, (2) education and (3) humanities. In order to understand its development, this research combines business aesthetics with related ideas from other management subjects. It develops seventeen course topics in business aesthetics through two-time modified Delphi Method, and collects many important ideas from twelve experts of business aesthetics. The research results reveal that the seventeen course topics in business aesthetics have strong impact on peopl
碩士
國立臺中教育大學
諮商與應用心理學系碩士班
102
The purpose of this present study was to examine the relationships among attachment toward parental attachment, public self-consciousness, and solitude experience among ...male and female young adult.
Convenience sampling was used in the study. A sample of 412 youth adults was recruited through personal connection. There were consisted of 147 male and 265 female. The measurements adopted in this study included the Scale of Relationships Structures Questionnaire-Chinese, the Scale of Self-Consciousness Scale, and the Scale of Solitude Experience. The data were analyzed by applying descriptive statistics, one-way analysis of variance, Pearson product moment correlation analysis and structural equation modeling.
The findings of this study were summarized as follow:
1. There existed significant gender differences on levels of public self-consciousness and positive experience of solitude experience. Specifically, female youth adults reported higher levels of public self-consciousness and
碩士
國立成功大學
醫學檢驗生物技術學系
94
Many species of dermatophytes (Epidermophyton, Microsporum and Trichophyton) are human pathogens. The aims of this study was to construct a database of ribosomal DNA internal ...transcribed spacer (ITS) sequences and an oligonucleotide array to identify 17 species of dermatophytes. The ITS sequences of type strains and reference strains were sequenced and combined with ITS sequences of reference strains available in GenBank, ITS sequence database were constructed. The ITS sequences of dermatophytes had high intraspecies similarities and low interspecies similarities, and this characteristic was used to design species-specific oligonucleotide probes. A total of 128 target clinical isolates were identified by ITS sequencing and a sensitivity of 100% (128/128) was obtained. In addition, 20 species-specific oligonucleotide probes were used to fabricate a DNA chip (0.5 cm × 0.5 cm) to identify 17 species of dermatophytes. The ITS regions of dermatophytes were amplified by PCR and hybridized to
碩士
國立暨南國際大學
應用化學系
102
Organic light-emitting materials have attracted considerable interest for recent years. In particular, aggregation induced emission (AIE) material have been focus of many recent ...studies, especially the effect of structural changes in organic light-emitting material. In this thesis, we introduce the AIE mechanism in detail. Based on the mechanistic understanding, we developed a series of new aggregation-induced emission compounds such as tetra (1-naphthyl) phenyl N-substituted phthalicamindes, which contain different substituents. Then, we explore the AIE effect of these compounds by measurement of fluorescence properties, absorption spectrum, emission spectrum and quantum yield. And we explore the solvent effect of these compounds.
碩士
國立中興大學
生物科技學研究所
101
Tea is widely consumed for over several thousand years in Mandarin China. Up to these days, tea has become the most consumed beverages around the world. In Taiwan, oolong tea ...is the most popular tea because of its unique flavor and taste. Astringent taste is considered to be one of the characteristics that lower the quality of oolong tea. The main substances causing astringent taste in oolong tea are catechins. Catechins can be further divided into two subgroups, non-gallate-type catechins and gallate-type catecins. It has been shown that gallate-type catecins are far more astringent than non-gallate-type catechins. In tea trees, the main non-gallate-type catechins are (-)-epicatechin (EC) and (-)-epigallocatechin (EGC), and the main gallate-type ones are (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG). Oolong tea produced from leaves of Camellia sinensis L. cultivated at higher altitude are generally tasted less astringent than those grown at lower altitude becaus
