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1.
  • Genetics: Implications for ... Genetics: Implications for Prevention and Management of Coronary Artery Disease
    Assimes, Themistocles L., MD, PhD; Roberts, Robert, MD Journal of the American College of Cardiology, 12/2016, Volume: 68, Issue: 25
    Journal Article
    Peer reviewed
    Open access

    Abstract An exciting new era has dawned for the prevention and management of coronary artery disease (CAD) utilizing genetic risk variants. The recent identification of over 60 susceptibility loci ...
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  • Alcohol use and cardiometab... Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study
    Lankester, Joanna; Zanetti, Daniela; Ingelsson, Erik ... PloS one, 08/2021, Volume: 16, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used ...
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  • An epigenetic clock analysi... An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
    Horvath, Steve; Gurven, Michael; Levine, Morgan E ... Genome Biology, 08/2016, Volume: 17, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Epigenetic biomarkers of aging (the "epigenetic clock") have the potential to address puzzling findings surrounding mortality rates and incidence of cardio-metabolic disease such as: (1) women ...
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  • DNA methylation GrimAge str... DNA methylation GrimAge strongly predicts lifespan and healthspan
    Lu, Ake T; Quach, Austin; Wilson, James G ... Aging (Albany, NY.), 01/2019, Volume: 11, Issue: 2
    Journal Article
    Open access

    It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of ...
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  • Genetics of 35 blood and ur... Genetics of 35 blood and urine biomarkers in the UK Biobank
    Sinnott-Armstrong, Nasa; Tanigawa, Yosuke; Amar, David ... Nature genetics, 02/2021, Volume: 53, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 individuals). ...
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  • The relationship between ci... The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study
    Johnson, Kelsey E; Siewert, Katherine M; Klarin, Derek ... PLoS medicine, 09/2020, Volume: 17, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    A number of epidemiological and genetic studies have attempted to determine whether levels of circulating lipids are associated with risks of various cancers, including breast cancer (BC). However, ...
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  • The glycolytic enzyme PKM2 ... The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease
    Shirai, Tsuyoshi; Nazarewicz, Rafal R; Wallis, Barbara B ... The Journal of experimental medicine, 03/2016, Volume: 213, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Abnormal glucose metabolism and enhanced oxidative stress accelerate cardiovascular disease, a chronic inflammatory condition causing high morbidity and mortality. Here, we report that in monocytes ...
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  • Menopause accelerates biolo... Menopause accelerates biological aging
    Levine, Morgan E.; Lu, Ake T.; Chen, Brian H. ... Proceedings of the National Academy of Sciences - PNAS, 08/2016, Volume: 113, Issue: 33
    Journal Article
    Peer reviewed
    Open access

    Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently, we developed a highly accurate ...
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  • Epigenetic clock analysis o... Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
    Quach, Austin; Levine, Morgan E; Tanaka, Toshiko ... Aging (Albany, NY.), 02/2017, Volume: 9, Issue: 2
    Journal Article
    Open access

    Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward ...
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  • Leveraging Multi-ethnic Evi... Leveraging Multi-ethnic Evidence for Risk Assessment of Quantitative Traits in Minority Populations
    Coram, Marc A.; Fang, Huaying; Candille, Sophie I. ... American journal of human genetics, 08/2017, Volume: 101, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    An essential component of precision medicine is the ability to predict an individual’s risk of disease based on genetic and non-genetic factors. For complex traits and diseases, assessing the risk ...
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