Decays of over forty short-lived (
T
1
2
from ≈ 50 ns to 70 μs) isomeric states including a new isomer
66mAs produced in the fragmentation of a
112Sn beam (58 A·MeV, 63 A·MeV) on a
natNi target were ...observed at the final focus of the LISE3 spectrometer at GANIL. Their detection, based on the slow (≈ 10 μs) time correlation of identified ions with the characteristic γ-radiation, represents a novel method to search for new isomers and can be used for unambiguous isotope identification for projectile fragment separator experiments. Isomeric yields and isomer-to-total production ratios were determined.
Six new neutron-deficient nuclei
103Sb,
104Sb,
98In,
91Pd,
89Rh and
87Ru have been identified among the products of quasi-fragmentation of a
112Sn beam (63 MeV/nucl.), in addition to the previously ...reported
100Sn and
102Sn. Decays of over forty short-lived (
T
1
2
from ≈50
ns to 70μ
s
) isomeric states including new isomer
66
m
As were observed in the same reaction.
Abstract
Two rabbit antisera, rendered specific for human J chains, were shown to cross-precipitate extensively with J chains of completely reduced and alkylated polymeric immunoglobulins (IgA, IgM, ...and/or SIgA) from the dog, cat, cow, goat, sheep, pig, horse, hedgehog, guinea pig, rat, mouse, and chicken. The data emphasize the great evolutionary stability of the J polypeptide chain.
Les dosages plasmatiques des inhibiteurs nucléosidiques de la transcriptase inverse du VIH sont réalisés par des méthodes de chromatographie liquide haute performance avec détection dans ...l'ultraviolet. Les méthodes permettant le dosage des métabolites intracellulaires triphosphorylés actifs ont été développées dans des laboratoires spécialisés et disposant de chromatographe liquide couplé à un spectrométre de masse en tandem. Elles restent du domaine de la recherche. Le suivi thérapeutique des inhibiteurs nucléosidiques de la transcriptase inverse n'est pas à l'heure actuelle recommandé, puisque seuls les métabolites triphosphorylés dans la cellule sont actifs; pour la majorité des nucléosides, aucune relation entre concentration plasmatique et concentrations intracellulaires du dérivé triphosphate n'a été mise en évidence.
High performance liquid chromatographic methods with UV detection were developped to assay nucleoside analogs inhibitors of HIV-1 reverse transcriptase in plasma. Intracellular concentration of nucleoside triphosphate, the active metabolite, can be measured by specific and sensitive assays such as liquid chromatography connected to tandem mass spectrometer. Such difficult assays were developped in a few research laboratories. There is poor relationship between plasma concentrations and intracellular concentrations of the triphosphate derivative. Therapeutic drug monitoring of nucleoside analogs are not recommanded in clinical practice.
Detection of bone marrow metastases by indirect immunofluorescence methods was investigated using three monoclonal antibodies (MoAbs) raised against small cell lung cancer (SCLC). These antibodies, ...designated anti-LCA1, -LCA2 and -LCA3, recognize three different antigens on the surface of SCLC cells. Eighty-four bone marrow samples from 74 different patients were studied. Whereas tumor cells were found in 32 (38%) by MoAb staining, only 10 (12%) were positively identified using conventional morphological methods. Nine out of the morphologically positive specimens showed reactivity with at least two monoclonal antibodies. Among the 32 samples proven positive by immunofluorescence, an important antigenic variability was noted. Anti-LCA1 recognized tumor cells in 62%, anti-LCA2 and anti-LCA3 in 53%. Due to the recognition of bone marrow involvement by fluorescence methods in 26% of the 34 patients classified as limited disease, a new subgroup of limited disease patients was defined whose prognosis remains undetermined. Our results confirm the utility of immunodetection in the diagnosis of SCLC bone marrow metastases and emphasize the advantage of using a panel of MoAbs with different antigenic specificities. Further study is needed to determine the prognostic significance of bone marrow involvement established by immunodetection.
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