The pharmacokinetic properties and tolerability of three different strengths of prulifloxacin (CAS 123447-62-1), a new antibacterial agent prodrug of AF3013 (CAS 112984-60-8), have been investigated ...in a randomized, cross-over study performed in 12 Caucasian male subjects (age range 19-34 years). Prulifloxacin was administered as a single oral dose at the dosages of 300, 450 and 600 mg. Plasma concentrations of the active metabolite AF3013 were determined in blood samples collected before the administration (pre-dose) and at 15, 30, 45 min, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, 24, 36 and 48 h after dosing. Urine samples were also collected. Determination in biological samples was performed using validated and specific HPLC methods. The following parameters were calculated: Cmax, tmax, AUC0-t, AUC0--infinity, t1/2, V/F, Aeut, CLren and fe. The analysis of variance performed on dose-normalized data after logarithmic transformation evidenced no statistically significant differences between the three doses concerning Cmax and AUC. Friedman's test applied to tmax and t1/2 did not show any statistically significant difference between doses. A significant linear relationship between doses and AUC0-infinity was detected (p < 0.05). Very high urinary concentrations and the relatively long terminal half-life (10-12 h) suggest that a once-daily application would show adequate clinical efficacy, especially in urinary infections. The safety profile of the three doses was very good.
Se estudió el desarrollo arquitectural en tres años de plántulas de Nothofagus obliqua bajo condiciones de vivero. Las plántulas derivaron de semillas de cinco procedencias dentro del área de ...distribución natural de esta especie en Argentina. En no menos de 40 plantas por procedencia se registraron: longitud, número de nudos y diámetro basal de los brotes anuales del eje vertical principal. El brote del primer año de todas las plántulas consistió en una sola unidad de alargamiento (UA), el del segundo año en una o dos UA y el del tercero en una, dos o tres UA. El desarrollo de dos o tres UA resultó invariablemente de la muerte del meristema apical luego de la primera UA. Las consecuencias más evidentes de la existencia de más de un evento de alargamiento en un año fueron: (a) mayores longitud y número de nudos en ese año, (b) mayor engrosamiento del tronco al nivel del suelo y (c) un período de alargamiento más largo. Plantas de diferente procedencia difirieron en la longitud del brote del primer año y en las proporciones de brotes de los años siguientes con una o varias UA.
Shoot growth and dieback were compared among progenies of nursery-grown seedlings of Nothofagus obliqua belonging to seven progenies of the same provenance (Quila-Quina, Argentina). First-year shoots ...consisted of one growth unit (GU) and second-year shoots of one or two GUs. The probability of development of two GU was similar for all progenies. Progenies were different in terms of shoot size, terminal bud abscission, the extent of shoot dieback after shoot extension and the node of origin of the relay shoot on the first shoot. Plants with a second-year shoot consisting of two GUs had a thicker stem and more nodes than those with single-GU shoots. The selection of N. obliqua seed trees based on architectural traits suitable for forestry development at specific sites must contemplate variability among progenies and their probabilities of successful development under different conditions.
Shoot growth and dieback were compared among progenies of nursery-grown seedlings of Nothofagus obliqua belonging to seven progenies of the same provenance (Quila-Quina, Argentina). First-year shoots ...consisted of one growth unit (GU) and second-year shoots of one or two GUs. The probability of development of two GU was similar for all progenies. Progenies were different in terms of shoot size, terminal bud abscission, the extent of shoot dieback after shoot extension and the node of origin of the relay shoot on the first shoot. Plants with a second-year shoot consisting of two GUs had a thicker stem and more nodes than those with single-GU shoots. The selection of N. obliqua seed trees based on architectural traits suitable for forestry development at specific sites must contemplate variability among progenies and their probabilities of successful development under different conditions.
Shoot development and dieback in progenies of Nothofagus obliqua Puntieri , Javier (Universidad Nacional del ComahueConsejo Nacional de Investigaciones Científicas y Técnicas, Bariloche(Argentine). Departamento de Botanica); Grosfled , Javier (Universidad Nacional del ComahueConsejo Nacional de Investigaciones Científicas y Técnicas, Bariloche(Argentine). Departamento de Botanica); Stecconi , Marina (Consejo Nacional de Investigaciones Científicas y Técnicas(Argentine).) ...
2007
Publication
Shoot growth and dieback were compared among progenies of nursery-grown seedlings of Nothofagus obliqua belonging to seven progenies of the same provenance (Quila-Quina, Argentina). First-year shoots ...consisted of one growth unit (GU) and second-year shoots of one or two GUs. The probability of development of two GU was similar for all progenies. Progenies were different in terms of shoot size, terminal bud abscission, the extent of shoot dieback after shoot extension and the node of origin of the relay shoot on the first shoot. Plants with a second-year shoot consisting of two GUs had a thicker stem and more nodes than those with single-GU shoots. The selection of N. obliqua seed trees based on architectural traits suitable for forestry development at specific sites must contemplate variability among progenies and their probabilities of successful development under different conditions.
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