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•Amorphous CoO nanosheets (CoO-A) were rapidly synthesized within 5 min.•CoO-A exhibited excellent catalytic activity for activating PMS to degrade 4-CP.•Superior activity was ...ascribed to the amorphous structure and large surface area.•SO4− was the dominant reactive oxygen species responsible for 4-CP decomposition.
Amorphous CoO nanosheets (CoO-A) were prepared in a short time and large scale for the first time via NaBH4 reduction, and applied as a catalyst for PMS activation to remove parachlorophenol (4-CP). Approximately 100% of 4-CP (10 mg/L) was degraded by PMS (0.25 mM) activated with CoO-A (0.03 g/L) with the kinetic constants of 0.428 min−1, which was 5.7 and 214.0 times higher than crystalline CoO/PMS and Co3O4/PMS systems, respectively. The superior catalytic performance was ascribed to the synergy of large surface area and amorphous structure of CoO nanosheets. Moreover, the effects of water matrix species and reaction parameters on 4-CP degradation were systematically investigated. The hydroxyl radicals and sulfate radicals were detected and involved in CoO-A/PMS system for 4-CP oxidation, and sulfate radicals made the primary contribution. The redox circles of Co2+/Co3+ on CoO-A surface were mainly responsible for the catalytic activation of PMS, and the possible activation mechanism and degradation pathway were proposed.
We studied changes in the choroid, particularly variation in blood flow, during the development of myopia. The hemodynamic mechanism in play remains unclear. We evaluated blood flow by quantitating ...indocyanine green (ICG) fluorescence in a guinea pig model of form-deprivation myopia.
Guinea pigs were divided into form-deprivation myopia (FDM) and normal control (NC) groups. Ocular biometric and choroidal hemodynamics parameters were quantitatively derived via ICG imaging, and included the maximal ICG fluorescence intensity (I
), rising time (T
), blood flow index (BFI), and mean transit time (MTT).
Form deprivation was associated with significant interocular differences in terms of both refractive error and axial length. ICG fluorescence hemodynamic maps of fundal blood flow and vasculature density were evident. In deprived eyes, the fluorescence signals exhibited significantly longer T
and MTT but lower I
and BFI than fellow eyes and NC group. The interocular differences in terms of the ocular biometric and hemodynamic parameters were significantly correlated. Hemodynamic analysis of choriocapillaris lobules revealed weakened fluorescence intensity and prolonged arrival and filling times in deprived eyes. Form deprivation reduced the number of lobulated choriocapillaris structures.
Form-deprivation myopia triggered changes in the hemodynamic and vascular network structures of the choroid and choriocapillaris. The ICG fluorescence imaging/analysis method provides a unique tool for further myopia research.
Purpose. To investigate the levels of transforming growth factor-β (TGF-β) in human aqueous humor (AH) and plasma (PL) of patients with myopia, and verify whether there is an association between ...these levels and their association with axial length (AL). Methods. Thirty-eight myopic patients who received intraocular collamer lens (ICL) implantation were enrolled in this cross-sectional study. Patients were divided into three groups based on AL with cut-off points of 26 and 28 mm. AH and PL samples were obtained during ICL implantation surgery. The levels of TGF-β1, TGF-β2, and TGF-β3 in the AH and PL samples were measured using Luminex xMAP Technology kits (Milliplex xMAP kits). The protein levels of TGF-βs in both AH and PL samples and their relationships with AL were analyzed. Results. In all, 38 patients (59 eyes) were enrolled and divided into the three groups: group A contained 7 people (10 eyes), group B contained 22 people (37 eyes), and group C contained 9 people (12 eyes). In the AH group, we detected TGF-β1 (P50: 19.97 pg/mL), TGF-β2 (2446.00 pg/mL), and TGF-β3 (26.33 pg/mL); in PL, these concentrations were 8984.00, 523.44, and 210.47 pg/mL, respectively. The levels of TGF-β1 and TGF-β3 in AH were positively associated with AL. None of the three isoforms in PL were related to those in AH or to AL. Conclusions. The levels of TGF-β1 and TGF-β3 in AH were more strongly associated with the severity of myopia than the types of TGF-β in PL.
We examined the lipid profiles in the aqueous humor (AH) of myopic patients to identify differences and investigate the relationships among dissertating lipids. Additionally, we assessed spherical ...equivalents and axial lengths to explore the pathogenesis of myopia. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was employed to qualitatively and quantitatively analyze the lipid composition of samples from myopic patients with axial lengths <26 mm (Group A) and >28 mm (Group B). Differences in lipid profiles between the two groups were determined using univariate and multivariate analyses. Receiver operator characteristic (ROC) curves were used to identify discriminating lipids. Spearman correlation analysis explored the associations between lipid concentrations and biometric parameters. Three hundred and nine lipids across 21 lipid classes have been identified in this study. Five lipids showed significant differences between Group B and Group A (VIP > 1, P < 0.05): BMP (20:3/22:3), PG (22:1/24:0), PS (14:1/22:4), TG (44:2)_FA18:2, and TG (55:3)_FA18:1. The area under the curve (AUC) for these lipids was >0.75. Notably, the concentrations of BMP (20:3/22:3), PS (14:1/22:4), and TG (55:3)_FA18:1 were correlated with spherical equivalents, while BMP (20:3/22:3) and PS (14:1/22:4) correlated with axial lengths. Our study identified five differential lipids in myopic patients, with three showing significant correlations with the degree of myopia. These findings enhance our understanding of myopia pathogenesis through lipidomic alterations, emphasizing changes in cell membrane composition and function, energy metabolism and storage, and pathways involving inflammation, peroxisome proliferator-activated receptors (PPAR), and metabolic processes related to phosphatidylserine, phosphatidylglycerol, triglycerides, polyunsaturated fatty acids, and cholesterol.We examined the lipid profiles in the aqueous humor (AH) of myopic patients to identify differences and investigate the relationships among dissertating lipids. Additionally, we assessed spherical equivalents and axial lengths to explore the pathogenesis of myopia. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was employed to qualitatively and quantitatively analyze the lipid composition of samples from myopic patients with axial lengths <26 mm (Group A) and >28 mm (Group B). Differences in lipid profiles between the two groups were determined using univariate and multivariate analyses. Receiver operator characteristic (ROC) curves were used to identify discriminating lipids. Spearman correlation analysis explored the associations between lipid concentrations and biometric parameters. Three hundred and nine lipids across 21 lipid classes have been identified in this study. Five lipids showed significant differences between Group B and Group A (VIP > 1, P < 0.05): BMP (20:3/22:3), PG (22:1/24:0), PS (14:1/22:4), TG (44:2)_FA18:2, and TG (55:3)_FA18:1. The area under the curve (AUC) for these lipids was >0.75. Notably, the concentrations of BMP (20:3/22:3), PS (14:1/22:4), and TG (55:3)_FA18:1 were correlated with spherical equivalents, while BMP (20:3/22:3) and PS (14:1/22:4) correlated with axial lengths. Our study identified five differential lipids in myopic patients, with three showing significant correlations with the degree of myopia. These findings enhance our understanding of myopia pathogenesis through lipidomic alterations, emphasizing changes in cell membrane composition and function, energy metabolism and storage, and pathways involving inflammation, peroxisome proliferator-activated receptors (PPAR), and metabolic processes related to phosphatidylserine, phosphatidylglycerol, triglycerides, polyunsaturated fatty acids, and cholesterol.
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•Z-scheme AgBr/BiO(HCOO)0.75I0.25 composites exhibited superior photocatalytic activity for BPA elimination.•Complicated water matrix only slightly affected the ...AgBr/BiO(HCOO)0.75I0.25/VL system.•O2−, 1O2 and photogenerated holes played primary roles in BPA degradation.•AgBr/BiO(HCOO)0.75I0.25/VL system exhibited a highly selective oxidation on aromatics with electron donating groups.
Herein, a novel AgBr/BiO(HCOO)0.75I0.25 Z-scheme photocatalyst was constructed through a facile hydrothermal and post-precipitation method for visible-light (VL) driven wastewater remediation. The 10 wt% AgBr/BiO(HCOO)0.75I0.25 composite (10%ABB) could completely decompose bisphenol A (BPA) within 25 min, and multiple coexisting inorganic anions and natural organic matters only slightly affected the BPA removal efficiency. The wonderful photocatalytic performance could attribute to the construction of Z-scheme heterojunction, which modulated the energy band, accelerated the electron transfer and also raised the redox ability of the system. Since the superoxide radicals (O2−) and non-radical pathway (1O2 and h+) were proved to be the dominating reactive species, 10%ABB/VL system exhibited a highly selective oxidation on aromatics with electron donating groups, whereas a relatively low value for organics with electron with drawing groups. By investigating the ionization potential (IP) of five representative organics, a negative correlation between IP value and reaction kinetics was reported. Moreover, the possible photocatalytic mechanism and elimination pathway were proposed via a series of photoelectrochemical analysis and LC-MS/MS. This work provides a strategy for engineering novel Bi-based photocatalyst and establishing selective oxidation system for organic contamination removal.
The Spartina alterniflora has severely invaded the coastal mangrove ecosystems in China. Here, we attempt to evaluate the invasion effect of S. alterniflora and the restoration effect of mangrove ...wetlands from the perspective of the nitrogen cycle characteristics. The inorganic nitrogen content, soil nitrogen mineralization, ammonification, and nitrification rate of uninvaded mudflats with those of invaded S. alterniflora site and native Kandelia obovata site at different restoration stages were compared. The results showed that the NH4+–N was the dominant form of soil inorganic nitrogen at all sites. Owing to its higher ammonification rates, the nitrogen mineralization rates at S. alterniflora site were highest in spring and summer among all sites except for mudflat. The young mangrove (1 year and 8 years) had significantly higher soil inorganic nitrogen content but lower nitrogen mineralization than the mature mangrove, indicated the short‐term response to restoration. The S. alterniflora invasion did not enhance soil nitrogen mineralization comparing with preinvaded mudflat, but it used more NH4+–N relative to K. obovata due to its higher soil nitrogen mineralization than mangrove communities in germination and growing seasons.
Recent studies have generated a large amount of data supporting the hypothesis that hypoxia drives tumor angiogenesis. The relationship between the two is often considered a matter of supply and ...demand: ineffectively-vascularized tumor tissue becomes hypoxic, stimulating neoangiogenesis to improve the influx of oxygen, thereby diminishing the angiogenic drive. Although this paradigm is logically pleasing, much of what is known about tumor biology argues against such a straightforward relationship. In fact, some preclinical data convincingly shows that tumor hypoxia and angiogenesis do not always go hand in hand. It is important to begin to explore means of reconciling these discrepancies. Although poor oxygenation is a strong stimulus for tumor angiogenesis, (1) the pathogenesis of tumor hypoxia is much more complicated than the supply-demand paradigm lets on and (2) hypoxia is not necessarily sufficient or necessary for neovascularization to occur. These subtleties may help to explain why so much data disagrees with the current hypoxia-angiogenesis model and may begin to build a better understanding of the role hypoxia plays in tumor vascularization. This article will review what is known about hypoxia and angiogenesis in nononcological processes and will apply these lessons to tumor biology to more deeply describe their relationship.
ABSTRACT Building on prior research showing a positive link between internally generated cash flows and innovation output, we hypothesize and find that the inclusion of cash-flow performance metrics ...in CEOs’ compensation contracts positively impacts firm innovation. Our findings are consistent with the theory that cash-flow metrics incentivize CEOs to make prudent investment decisions, thereby addressing both the overinvestment and the underinvestment challenges for firm innovation. As a result, firms utilizing cash-flow metrics exhibit lower innovation input and higher innovation output compared to firms not employing such metrics. Furthermore, our research indicates that the incentive effect of cash-flow metrics on firm innovation is more pronounced when cash flows convey unique information not reflected in earnings and when CEOs have longer expected employment horizons. This study underscores the effectiveness of cash-flow metrics in motivating management to promote firm innovation. Data Availability: Subscription-based data are obtained from Wharton Research Data Services; public data are obtained from public sources specified in the paper. JEL Classifications: D81, G30, J33, M52.
In this study, we explored the individual and combined effects of ammonia-N and sulfide stress (1 mg/L sulfide and 15 mg/L ammonia-N) on the oxidation resistance, immune response and intestinal ...health of Litopenaeus vannamei during 72 h exposure. The total antioxidant capacity (T-AOC), malonaldehyde (MDA) and nitric oxide (NO) content, superoxide dismutase (SOD) and catalase activity (CAT), the immune-relative gene (caspase-3, hsp70 and IMD) expression in hepatopancreas and intestine of L.vannamei and the intestinal microbiota were measured. The result showed that MDA and NO contents in hepatopancreas of L. vannamei in all treatment groups increased and remain were at high levels at the end of the stress exposure. The L. vannamei employ antioxidant defense system by increasing the activities of T-AOC, SOD and CAT enzymes in hepatopancereas and intestine to reduce oxidant damage. More severe damages with combined ammonia-N and sulfide stress to antioxidant systems were observed. The gene expression results also demonstrated that antioxidant capacity of L. vannamei was severely impaired and the apoptosis cell was initiated under the ammonia-N and sulfide stress. In addition, the environmental stress also reshaped the intestinal microbial community structure of L. vannamei that a number of original genera decreased, such as Cellvibrio, Vibrio and Rheinheimera; some new genera increased or appeared, such as Photobacterium in all treatment groups, Arcobacter and Fusibacter in sulfide stress group. Therefore, the health of L. vannamei was severely impacted when exposed to the stress of ammonia nitrogen and sulfide and these two factors can have weak synergic effects.
•The oxidation resistance of Litopenaeus vannamei in ammonia-N and sulfide exposure were investigated.•The antioxidant capacity of L. vannamei was severely impaired and the apoptosis was initiated.•The intestinal microbiota of the L. vannamei were reshaped after 72 h exposure.•The ammonia-N and sulfide have a weak synergic effects.
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