•The materials are designed to bring insulating to structures built from 3D printing.•The mixes include flax shives, foam agent, and for some of them, earthern materials.•The studied mixes give a ...rapid hardening and low mechanical strengths.•Acoustic absorption coefficient of one mix is from 0.3 up to 0.55 (100–1500 Hz).•The measured lowest thermal conductivity is 0.085 W.m−1.K−1.
This research work aims to develop a rapid hardening lightweight composite including flax shives, foaming agent and earthern materials. The results show a satisfying workability just after the mixing step and a rapid hardening of about less than thirty minutes. The mixes with a large amount of flax shives show a thermal conductivity inferior to 0.1 W.m−1.K−1 and porous-like acoustic absorption coefficients. Even if the mechanical performances are low (fc28days = 0.1–1 MPa), the developed mixes, in association with a structural material, can be used with advantage the 3D printing technique.
•Study at microscale to determine permeability on a REV and connection to macroscale.•Analysis of wall shear stress by statistical functions at the microscale.•Identification of the optimal range of ...wall shear stress for a given Darcy velocity.•Numerical model for both description of fluid flow and cell growth at the macroscale.•Identification of the optimal flow rate in perfusion bioreactor.
Part of clinically applicable bone graft substitutes are developed by using mechanical stimulation of flow-perfusion into cell-seeded scaffolds. The role of fluid flow is crucial in driving the nutrient to seeded cells and in stimulating cell colonization. A common numerical approach is to use a multiscale model to link some physical quantities (wall shear stress and inlet flow rate) that act at different scales. In this study, a multiscale model is developed in order to determine the optimal inlet flow rate to cultivate osteoblast-like cells seeded in a controlled macroporous biomaterial inside a perfusion bioreactor system. We focus particularly on the influence of Wall Shear Stress on cell colonization to predict cell colonization at the macroscale. Results obtained at the microscale are interpolated at the macroscale to determine the optimal flow rate. For a macroporous scaffold made of interconnected pores with pore diameters of above 350 μm and interconnection diameters of 150 μm, the model predicts a cell colonization of 325% after a 7-day-cell culture with a constant inlet flow rate of 0.69 mL·min−1. Furthermore, the strength of this protocol is the possibility to adapt it to most porous biomaterials and dynamic cell culture systems.
Scleredema adultorum (Buschke's scleredema) is a cutaneous mucinosis of unknown origin, clinically characterized by a diffuse induration of the skin usually involving the neck, shoulders and back, ...which limits patients' mobility.
We report a case of a 50-year-old woman who presented a chronic sclerodermiform syndrome for 2 years associated with type 1 diabetes. Physical examination revealed an extensive skin induration involving the shoulders, neck and back. Histologic examination confirmed the diagnosis of scleredema adultorum. The patient was treated with extracorporeal photopheresis (EPP) twice a month for two months. At follow-up, mobility was highly improved after two months. Beneficial effect of EPP was maintained on the long term while sessions were spaced.
EPP is an unconventional treatment of Buschke's scleredema. We described a case of Buschke's scleredema successfully treated with EPP which may represent a therapeutic option for the treatment of scleredema.
Highlights • A bioprobe that is compatible with NMR for LITT (Laser-induced Interstitial Thermotherapy) has been developed. • Numerical simulations of the bioprobe's behaviour allowed for an ...estimation of the irradiated volume. • Ex vivo experiments on a target tissue in the liver provided validation of the bioprobe and of the numerical study results.
Introduction The exposure of the patients’ entourage who underwent vectorized internal radiation therapy is a subject that raises many questions. We have already conducted a study on the entourage of ...patients treated for thyroid cancer 1 , this time we have focused on patients with hyperthyroidism. These patients do not benefit of any hospitalization, though it is important to know the impact of radiation protection instructions in the exposure of their cohabitants. Material and method For this study, we have solicited the entourage of 34 patients treated for hyperthyroidism by administering radioiodine capsule. These people agreed to be dose-monitored wearing an OSL (Optically Stimulated Luminescence) dosimeter on a collar during 10 days, noting the details of their days, the hours and distance passed in the presence of the treated patient. We have analyzed their responses and mapped their exposure. Results The entourage exposure is of course related to the administered activity (fixed dose based on thyroid hormone levels). However, the link between the patient and the monitored person of his entourage, helps to define two distinct classes: Parents (20) and Spouses (14). The results show that spouses are more exposed than parents. However, in both cases, we measured exposures exceeding 1 mSv (10% of parents and 14% for spouses), the public’s exposure limit. Conclusion It is important to provide radiation protection instructions to outgoing vectorized internal radiation therapy’s patients, as well as their entourage, for both thyroid cancer and hyperthyroidism. Note that the non-compliance with these instructions can result an exposure exceeding 1 mSv, the public’s exposure limit.
An unexpected asymptomatic epiglottal site of Kimura disease Dezoteux, F.; Dubois, R.; Lefèvre, G. ...
European annals of otorhinolaryngology, head and neck diseases,
February 2019, 2019-Feb, 2019-02-00, 20190201, Volume:
136, Issue:
1
Journal Article
Peer reviewed
Open access
Kimura disease (KD) is a chronic lymphoproliferative disorder of unknown etiology that affects the skin and lymph nodes, mostly observed in males of Asian descent. The natural history of asymptomatic ...epiglottal KD remains unknown. This rare site of KD is often only diagnosed when tumor growth starts to obstruct the upper airways.
A 34-year-old North African male presented with fatigue and multiple, slowly progressive, fluctuating skin nodules in the right mandibular and retroauricular regions. Computed tomography of the head and neck revealed a large soft tissue tumor close to the right mandibular body and unexpected thickening of the epiglottis. Transnasal laryngoscopy confirmed the CT findings and showed thickening of the epiglottis. The diagnosis of KD was based on histological examination of biopsy specimens taken from the right mandibular tumor, a cervical lymph node, and the epiglottis.
Most cases of KD with epiglottal involvement present with dysphonia and dysphagia. No consensus guidelines are available concerning the complementary investigations that should be performed. This case report raises the question of whether patients with suspected KD should be systematically screened for lesions in unusual and potentially dangerous anatomic sites.
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