Fused‐ring electron acceptors have made significant progress in recent years, while the development of fully non‐fused ring acceptors has been unsatisfactory. Here, two fully non‐fused ring ...acceptors, o‐4TBC‐2F and m‐4TBC‐2F, were designed and synthesized. By regulating the location of the hexyloxy chains, o‐4TBC‐2F formed planar backbones, while m‐4TBC‐2F displayed a twisted backbone. Additionally, the o‐4TBC‐2F film showed a markedly red‐shifted absorption after thermal annealing, which indicated the formation of J‐aggregates. For fabrication of organic solar cells (OSCs), PBDB‐T was used as a donor and blended with the two acceptors. The o‐4TBC‐2F‐based blend films displayed higher charge mobilities, lower energy loss and a higher power conversion efficiency (PCE). The optimized devices based on o‐4TBC‐2F gave a PCE of 10.26 %, which was much higher than those based on m‐4TBC‐2F at 2.63 %, and it is one of the highest reported PCE values for fully non‐fused ring electron acceptors.
Two fully non‐fused acceptors are precisely designed and easily prepared. The side chain encapsulation can induce a planar molecular backbone conformation, endowing the acceptor with broad light absorption. Thermal annealing promotes molecular rearrangement to form J‐aggregates with even broader absorption and higher absorption coefficient. A PCE over 10 % is one of the highest PCE for fully non‐fused ring acceptors.
Bearing remaining useful life (RUL) prediction plays a crucial role in guaranteeing safe operation of machinery and reducing maintenance loss. In this paper, we present a new deep feature learning ...method for RUL estimation approach through time frequency representation (TFR) and multiscale convolutional neural network (MSCNN). TFR can reveal nonstationary property of a bearing degradation signal effectively. After acquiring time-series degradation signals, we get TFRs, which contain plenty of useful information using wavelet transform. Owing to high dimensionality, the size of these TFRs is reduced by bilinear interpolation, which are further regarded as inputs for deep learning models. Here, we introduce an MSCNN model structure, which keeps the global and local information synchronously compared to a traditional convolutional neural network (CNN). The salient features, which contribute for RUL estimation, can be learned automatically by MSCNN. The effectiveness of the presented method is validated by the experiment data. Compared to traditional data-driven and different CNN-based feature extraction methods, the proposed method shows enhanced performance in the prediction accuracy.
Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate ...abnormally in the presence of reactive oxygen species (ROS) and elevated lipid oxidation. Here we show, using a collagen-induced arthritis (CIA) mouse model, that imidazole ketone erastin (IKE), a ferroptosis inducer, decreases fibroblast numbers in the synovium. Data from single-cell RNA sequencing further identify two groups of fibroblasts that have distinct susceptibility to IKE-induced ferroptosis, with the ferroptosis-resistant fibroblasts associated with an increased TNF-related transcriptome. Mechanistically, TNF signaling promotes cystine uptake and biosynthesis of glutathione (GSH) to protect fibroblasts from ferroptosis. Lastly, low dose IKE together with etanercept, a TNF antagonist, induce ferroptosis in fibroblasts and attenuate arthritis progression in the CIA model. Our results thus imply that the combination of TNF inhibitors and ferroptosis inducers may serve as a potential candidate for RA therapy.
Da Silva et al. showed that the triglyceride-glucose (TyG) index was positively associated with a higher prevalence of symptomatic coronary artery disease (CAD). TyG has been used in healthy ...individuals as a marker of insulin resistance. The use of this index as a marker of atherosclerosis in cardiovascular disease (CVD) patients might be influenced by diabetes and the hyperlipidemic state that led to CVD. Certain considerations might be necessary before we conclude that the TyG index can be used as a marker of atherosclerosis in CVD patients. These factors can highlight the role of fasting blood glucose and triglyceride levels that are used in the TyG formula. Comparing the fasting blood glucose and/or triglyceride levels with the TyG index in these patients to show how much value the TyG index can add to clinical practice seems to be necessary. Conclusions of such studies might be biased by these facts. Stratification by CAD disease category cannot help achieve an understanding of the role of TyG in CVD. Correlations do not imply causation, so the use of the TyG index as an index in CAD patients is questionable.
Additive manufacturing provides great geometrical freedom for fabricating structures with complex or customized architecture. One of the applications benefiting from this technology is the ...fabrication of functionally graded materials with high degree of control of internal architecture which can be strategic application in advanced energy absorption. This study aims to explore the mechanical properties of functionally graded lattice structures fabricated by an additive manufacturing technique namely, selective laser melting (SLM), with Ti-6Al-4V as the building material. Both cubic lattice and honeycomb lattice structures with varied strut diameter and density were designed and manufactured, and their physical characteristics, deformation behavior and compressive properties were investigated. The collapse of structure always started from least dense layer to the denser layers. In contrast, samples with uniform density showed abrupt shear failure with diagonal cracking across the whole structure. The plateau stress and specific energy absorption of density graded samples were higher than for uniform density samples for three out of four designs by up to 67% and 72%, respectively. In addition, density graded lattices showed distinct energy absorption behavior with cumulative energy absorption increasing as a power of strain function while uniform density lattices showed a near-linear relationship.
Display omitted
•New designs of functionally graded material with continuous density change were investigated.•The designs were opposed to those reported in literature with abrupt change.•The designed structures were shown to have novel deformation behavior than homogenous counterparts under compression.•Plateau stress and specific energy absorption of the structures were higher than homogenous counterparts for most designs.
Summary
Grain/seed yield and plant stress tolerance are two major traits that determine the yield potential of many crops. In cereals, grain size is one of the key factors affecting grain yield. ...Here, we identify and characterize a newly discovered gene Rice Big Grain 1 (RBG1) that regulates grain and organ development, as well as abiotic stress tolerance. Ectopic expression of RBG1 leads to significant increases in the size of not only grains but also other major organs such as roots, shoots and panicles. Increased grain size is primarily due to elevated cell numbers rather than cell enlargement. RBG1 is preferentially expressed in meristematic and proliferating tissues. Ectopic expression of RBG1 promotes cell division, and RBG1 co‐localizes with microtubules known to be involved in cell division, which may account for the increase in organ size. Ectopic expression of RBG1 also increases auxin accumulation and sensitivity, which facilitates root development, particularly crown roots. Moreover, overexpression of RBG1 up‐regulated a large number of heat‐shock proteins, leading to enhanced tolerance to heat, osmotic and salt stresses, as well as rapid recovery from water‐deficit stress. Ectopic expression of RBG1 regulated by a specific constitutive promoter, GOS2, enhanced harvest index and grain yield in rice. Taken together, we have discovered that RBG1 regulates two distinct and important traits in rice, namely grain yield and stress tolerance, via its effects on cell division, auxin and stress protein induction.
Three nonfused ring electron acceptors (NFREAs), namely, 3TT‐C2‐F, 3TT‐C2‐Cl, and 3TT‐C2, are purposefully designed and synthesized with the concept of halogenation. The incorporation of F or/and Cl ...atoms into the molecular structure (3TT‐C2‐F and 3TT‐C2‐Cl) enhances the π–π stacking, improves electron mobility, and regulates the nanofiber morphology of blend films, thus facilitating the exciton dissociation and charge transport. In particular, blend films based on D18:3TT‐C2‐F demonstrate a high charge mobility, an extended exciton diffusion distance, and a well‐formed nanofiber network. These factors contribute to devices with a remarkable power conversion efficiency of 17.19%, surpassing that of 3TT‐C2‐Cl (16.17%) and 3TT‐C2 (15.42%). To the best of knowledge, this represents the highest efficiency achieved in NFREA‐based devices up to now. These results highlight the potential of halogenation in NFREAs as a promising approach to enhance the performance of organic solar cells.
Three nonfused ring electron acceptors (3TT‐C2‐F, 3TT‐C2‐Cl, and 3TT‐C2) are designed and synthesized with the concept of halogenation. Among them, the fluorinated acceptor 3TT‐C2‐F based devices can deliver the champion power conversion efficiency of over 17% due to enhanced the π–π stacking, improved the electron mobility, etc.
Three regioregular benzodithiophene‐based donor–donor (D–D)‐type polymers (PBDTT, PBDTT1Cl, and PBDTT2Cl) are designed, synthesized, and used as donor materials in organic solar cells (OSCs). Because ...of the weak intramolecular charge‐transfer effect, these polymers exhibit large optical bandgaps (>2.0 eV). Among these three polymers, PBDTT1Cl exhibits more ordered and closer molecular stacking, and its devices demonstrate higher and more balanced charge mobilities and a longer charge‐separated state lifetime. As a result of these comprehensive benefits, PBDTT1Cl‐based OSCs give a very impressive power conversion efficiency (PCE) of 17.10% with a low nonradiative energy loss (0.19 eV). Moreover, PBDTT1Cl also possesses a low figure‐of‐merit value and good universality to match with different acceptors. This work provides a simply and efficient strategy to design low‐cost high‐performance polymer donor materials.
Three D–D type wide‐bandgap donor polymers (PBDTT, PBDTT1Cl, and PBDTT2Cl) are designed and facilely synthesized. Organic solar cells (OSCs) based on PBDTT1Cl exhibit a high power conversion efficiency of 17% and a low nonradiative energy loss of 0.19 eV. In addition, PBDTT1Cl has a very low figure‐of‐merit and good universality, indicating its potential as a low‐cost polymer donor for high‐performance OSCs.
► In this study we study IT professionals’ perceptions and attitudes of cloud computing adoption in Taiwan. ► The findings of the study suggest that compatibility with company's business model and ...policy and customers’ demands are the main concerns. ► Relative advantages of cloud computing are not obvious to IT professionals therefore they are hesitant to adopt cloud solutions. ► Successful business cases and models will encourage companies to adopt cloud computing. ► It is the cost of adoption that concerns IT professionals not cost savings that can be made through adoption as suggested by the literature.
Cloud computing is a current trend that reveals the next-generation application architecture and it is estimated that by 2013 the cloud market will have reached $8.1bn. While cloud services such as webmail, Flickr and YouTube have been widely used by individuals for some time, it not until relatively recently that organisations have began to use cloud services as a tool for meeting their IT needs. This study aims to investigate how cloud computing is understood by IT professionals and the concerns that IT professionals have in regard to the adoption of cloud services. The study was carried out in Taiwan and used a survey by interview approach to understand IT professionals’ understandings and concerns about cloud computing. The findings of the study suggest that while the benefits of cloud computing such as its computational power and ability to help companies save costs are often mentioned in the literature, the primary concerns that IT managers and software engineers have are compatibility of the cloud with companies’ policy, IS development environment, and business needs; and relative advantages of adopting cloud solutions. The findings also suggest that most IT companies in Taiwan will not adopt cloud computing until the uncertainties associated with cloud computing, e.g. security and standardisation are reduced and successful business models have emerged.
PDF
