Purpose
Endometriosis is a benign estrogen-responsive disease which shares some characteristics with malignant tumors such as invasion and unrestrained growth. In this respect, the epidermal growth ...factor receptor family (EGFR or erbB-1 and erbB-2 to -4) is known to play an important role in tumor biology. The aims of the present study were: 1) to investigate the expression patterns of the four erbB receptors, 2) to ascertain if there was a correlation between the EGFR family expression and the expression of the estrogen receptor α (ERα).
Methods
Retrospective study: 48 peritoneal and 12 ovarian human endometriotic lesions were analyzed by immunohistochemistry. The confirmation of the immunohistochemical findings was made by Western blot analysis. Using the Mann-Whitney-U test, statistical analysis was performed.
Results
In peritoneal and ovarian endometriosis, all members of the EGFR family and ERα are detectable in stromal and epithelial cells, but the expression is different within the tissues. Only in ovarian endometriosis was a statistical association observed between EGF receptor and ERα expression (p<0.017).
Conclusions
The differential expression of the erbB receptors suggest that the erbB family might play an important role in the pathogenesis of endometriosis. A significant association between EGF receptor expression and the ERα expression was only found in ovarian endometriosis.
The coefficient of scleral rigidity of the eyes of 29 patients with age-related macular degeneration (ARMD) was significantly higher than the rigidity of 25 control patients, frequency matched for ...age. The data suggest that an increased scleral rigidity may be a significant risk factor for the development of the disorder.
Provider: - Institution: - Data provided by Europeana Collections- Dauer: 01:48 Min.- Interpretation: Moderation: Hanns Ander-Donath. Sprachaufnahmen von: 1) Gerda Wetzel, 2) Inge Zeuner, 3) Frieda ...Wetzel, 4) Oskar Zeuner, 5) Johanna Zeuner, 6) Hilma Ebert und 7) Käthe Ebert- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
PDF
