A novel Schiff base namely (E)‐3‐((2,6‐dihydroxypyrimidin‐4‐ylimino)methyl)‐4H‐chromen‐4‐one and its Co (II), N (II)i, Cu (II) and Cd (II) complexes have been synthesized and proved by elemental ...analysis, molar conductance, thermal analysis (TGA), Inductive Coupled plasma (ICP), magnetic moment measurements, X‐ray powder diffraction, IR, EI‐mass,1H NMR, 13C NMR,UV–Vis. and ESR spectral studies. On the basis of these data, it is evident that the Schiff base acts as bidentate via oxygen atom of carbonyl group and azomethine nitrogen atom for Co (II) complex; monobasic bidentate ligand for Ni (II), Cu (II) and Cd (II) complexes via oxygen atom of hydroxyl group and nitrogen atom of pyrimidine ring. The results showed all complexes have octahedral geometry. The average particle size of the ligand and its complexes were found to be 1.010–0.343 nm. The pharmacological action (antioxidant, antimicrobial and anticancer) of the prepared compounds is studied. The antitumor activity of the ligand and its metal complexes is evaluated against human liver carcinoma (HEPG2) cell. The data displayed the Co (II) complexes strong cytotoxicity where IC50 values of Co (II) complex and 5‐fluorouracil (stander drug) are 9.33 and 7.86 μg/ml respectively. The Co (II) and Cd (II) complexes have antibacterial activity more than ampicillin (stander drug). The interaction of the synthesized compounds with calf‐thymus DNA (CT‐DNA) has been performed via absorption spectra and viscosity technique. The DNA‐ binding constants have been determined.
A novel Schiff base namely (E)‐3‐((2,6‐dihydroxypyrimidin‐4‐ylimino)methyl)‐4H‐chromen‐4‐one and its Co(II), N(II)i, Cu(II) and Cd(II) complexes have been synthesized and proved. The pharmacological action (antioxidant, antimicrobial and anticancer)of the prepared compounds were studied.
The azo dye ligand N-diaminomethylene-4-(3-formyl-4-hydroxy-phenylazo)-benzenesulfonamide (HL) and Cu(II), Co(II), and Mn(II) coordination polymers were synthesized in addition to a non-polymeric ...Pd(II) complex. In all complexes, the ligand bonds to the metal ion through the formyl and α-hydroxy oxygen atoms. The sulfonamide oxygen also coordinates to the metal. The complexes are formulated as ML
2
n
, where M = Cu(II), Co(II), and Mn(II), and ML(Cl)(H
2
O), where M = Pd(II). On the basis of spectral studies and magnetic susceptibility measurements, an octahedral geometry was assigned to Co(II) and Mn(II) complexes, tetragonally elongated octahedral geometry for Cu(II) complex, while the Pd(II) complex was found to be square planar. Crystallization of Cu(II) complex from DMF afforded single crystals of general formula {Cu(L)
2
· 3DMF}
n
(2). X-ray structural analysis of 2 revealed that each Cu(II) adopts elongated octahedral geometry affording 1-D chains. The chains are connected by hydrogen bonds, resulting in the formation of 2-D supramolecular assemblies. The crystal structure of HL has also been determined and discussed. Cyclic voltammetric behavior of the ligand and some complexes are also discussed.
A new Schiff base, namely 3-{(5-mercapto-1,3,4-thiadiazol-2-ylimino) methyl}-4H-chromen-4-one, and its complexes of divalent Co, Ni, and Cu ions have been synthesized. Elemental analyses, molar ...conductance, thermal analysis (TGA), inductive coupled plasma (ICP), magnetic moment measurements, and spectral techniques (X-ray powder diffraction, IR, EI-mass,
1
H NMR,
13
C NMR, UV–Vis, and ESR spectral studies) have been employed for structure elucidation of the target complexes. The spectral and analytical data revealed that the Schiff base acts as monobasic tetradentate ligand via deprotonated SH, oxygen atom of carbonyl group, and azomethine nitrogen atom for Ni
2+
and Cu
2+
complexes; bidentate via oxygen atom of carbonyl group and azomethine nitrogen atom for Co
2+
complex. Molecular modeling calculations confirm the structural geometry of the complexes. The complexes were assayed for their in vitro antimicrobial activities against some bacterial strains. The anticancer activity of the target compounds is evaluated against human
liver carcinoma
(HEPG2) cell. These compounds exhibited weak activities against the tested HEPG2 cell lines. The interaction of the investigated materials with calf-thymus DNA was also studied.
The title molecule, C
17
H
13
N
5
O
4
S, has a
trans
configuration with respect to the diazenyl (azo) group. The pyrimidine ring and the terminal benzene ring are inclined at angles of 89.38 (4) and ...1.6 (6)°, respectively, with respect to the central benzene ring. The conformation of the molecule is in part stabilized by an intramolecular O—H...O hydrogen bond. In the crystal structure, molecules related through inversion centers form hydrogen-bonded dimers involving the sulfonamide N—H group and the N atom of the pyrimidine ring.
In the title compound, CoBr(2)(C(14)H(24)N(4))·Br, the Co(III) ion is located on an inversion centre and possesses a distorted octa-hedral coordination geometry in which four nitro-gen donors of the ...ligand mol-ecule are in the equatorial plane and two Br(-) ions occupy both the axial sites to give a trans isomer. The Br(- )counter- anion is also located on an inversion centre.
Fe(III), Co(II), Ni(II), and Cu(II) complexes of the title azodyes have been synthesized and characterized by elemental analysis, molar conductance, TGA, DTA, magnetic susceptibility measurements, ...IR, electronic and ESR spectral studies. The spectral studies suggest an octahedral geometry for Fe(III) and Co(II) complexes but a square planar geometry for Ni(II) and Cu(II) complexes. The kinetics of the catalysed oxidation of N,N,N′,N′-tetramethyl-p-phenylenediamine dihydrochloride (TMPPD) with mononuclear and binuclear copper complexes were studied to check the activity of these copper complexes in oxidizing organic amines. The electrochemical behaviour of the metal complexes was studied using DC polarography and cyclic voltammetry. Antimicrobial activity of the azo compounds and its complexes have been tested against different microorganisms.
The asymmetric unit the title compound, C18H16N4O3S·2C3H7NO, contains a molecule in a zwitterionic form with a deprotonated hydroxyl group and an iminium group, and two dimethylformamide solvent ...molecules. The dihedral angles of the guanidine group and the naphthyl ring system with respect to the central benzene ring are 76.04 (7) and 3.45 (9)°, respectively. The conformation of the molecule may be influenced, in part, by two intramolecular hydrogen bonds, while in the crystal structure, intermolecular hydrogen bonds form one-dimensional chains along 010.
The electronic absorption spectra of some bisazo-dianils are studied in organic solvents of different polarity and in buffer solutions of varied pH. The different absorption bands are assigned to the ...corresponding electronic transitions, the solvent effect on the CT band energy is also discussed. The spectral study in buffer solutions is utilized for the determination of the p
K
a of the phenolic OH-groups. The important bands in the IR spectra as well as the signals of the
1
H
NMR spectra are assigned and discussed in relation to molecular structure. The fluorescence spectra of the compounds are recorded. The fluorescence quantum yield and p
K in the ground and excited states are determined.
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