ABSTRACT
We study the dust properties of 192 nearby galaxies from the JINGLE survey using photometric data in the 22–850 $\mu$m range. We derive the total dust mass, temperature T, and emissivity ...index β of the galaxies through the fitting of their spectral energy distribution (SED) using a single modified blackbody model (SMBB). We apply a hierarchical Bayesian approach that reduces the known degeneracy between T and β. Applying the hierarchical approach, the strength of the T–β anticorrelation is reduced from a Pearson correlation coefficient R = −0.79 to R = −0.52. For the JINGLE galaxies we measure dust temperatures in the range 17−30 K and dust emissivity indices β in the range 0.6−2.2. We compare the SMBB model with the broken emissivity law modified blackbody (BMBB) and the two modified blackbody (TMBB) models. The results derived with the SMBB and TMBB are in good agreement, thus applying the SMBB, which comes with fewer free parameters, does not penalize the measurement of the cold dust properties in the JINGLE sample. We investigate the relation between T and β and other global galaxy properties in the JINGLE and Herschel Reference Survey (HRS) sample. We find that β correlates with the stellar mass surface density (R = 0.62) and anticorrelates with the H i mass fraction (MH i/M*, R = −0.65), whereas the dust temperature correlates strongly with the star formation rate normalized by the dust mass (R = 0.73). These relations can be used to estimate T and β in galaxies with insufficient photometric data available to measure them directly through SED fitting.
ABSTRACT
The content and distribution of cool interstellar medium (<30 K) can indicate the evolutionary mechanisms that transform late-type to early-type galaxies (ETGs). To investigate this, ALMA ...observations of 12CO2-1 line emission were obtained for five dusty ETGs from a complete sample in low-density environments. Four of the ETGs have massive (∼109 M⊙), extended molecular gas reservoirs with effective radii ∼3–5 kpc. This work provides a kinematic and structural analysis of these observations, to explore possible evolutionary mechanisms. Axisymmetric or bisymmetric kinematic models were fitted to observations of molecular gas discs, to quantify the dominant structures present and highlight additional structures or asymmetries. Integral field unit observations of these ETGs were also examined where available. Two of the ETGs, GAMA64646 and 622305, appear to have undergone tidal disturbance leading to molecular gas discs and/or star-forming inner rings. GAMA272990 may have undergone a merger, leading to an elliptical galaxy with an embedded star-forming molecular gas disc. GAMA622429 has probably undergone a minor merger, indicated by asymmetry in molecular gas distribution and disturbance in optical images. The remaining ETG, GAMA177186, was affected by source confusion from an offset source which could be a high-mass dust- and gas-rich object at high redshift. Overall, it appears that a high proportion of dusty ETGs in low-density environments have massive, extended molecular gas reservoirs, and have undergone some kind of interaction as part of their recent evolution. Secular evolution can then (re-)transform the ETGs from star-forming to passive galaxies.
The content and distribution of cool interstellar medium (ISM, <30K) can indicate the evolutionary mechanisms that transform late type to early type galaxies (ETGs). To investigate this, ALMA ...observations of 12CO2-1 line emission were obtained for five dusty ETGs from a complete sample in low-density environments. Four of the ETGs have massive (approximately 10^9 Msolar), extended molecular gas reservoirs with effective radii of approximately 3 to 5 kpc. This work provides a kinematic and structural analysis of these observations, to explore possible evolutionary mechanisms. Axisymmetric or bisymmetric kinematic models were fitted to observations of molecular gas discs, to quantify the dominant structures present and highlight additional structures or asymmetries. Integral Field Unit (IFU) observations of these ETGs were also examined where available. Two of the ETGs, GAMA64646 and 622305, appear to have undergone tidal disturbance leading to molecular gas discs and/or star-forming inner rings. GAMA272990 may have undergone a merger, leading to an elliptical galaxy with an embedded star-forming molecular gas disc. GAMA622429 has probably undergone a minor merger, indicated by asymmetry in molecular gas distribution and disturbance in optical images. The remaining ETG, GAMA177186, was affected by source confusion from an offset source which could be a high mass, dust- and gas- rich object at high redshift. Overall, it appears that a high proportion of dusty ETGs in low-density environments have massive, extended molecular gas reservoirs, and have undergone some kind of interaction as part of their recent evolution. Secular evolution can then (re-)transform the ETGs from star-forming to passive galaxies.
We study the dust properties of 192 nearby galaxies from the JINGLE survey using photometric data in the 22-850micron range. We derive the total dust mass, temperature T and emissivity index beta of ...the galaxies through the fitting of their spectral energy distribution (SED) using a single modified black-body model (SMBB). We apply a hierarchical Bayesian approach that reduces the known degeneracy between T and beta. Applying the hierarchical approach, the strength of the T-beta anti-correlation is reduced from a Pearson correlation coefficient R=-0.79 to R=-0.52. For the JINGLE galaxies we measure dust temperatures in the range 17-30 K and dust emissivity indices beta in the range 0.6-2.2. We compare the SMBB model with the broken emissivity modified black-body (BMBB) and the two modified black-bodies (TMBB) models. The results derived with the SMBB and TMBB are in good agreement, thus applying the SMBB, which comes with fewer free parameters, does not penalize the measurement of the cold dust properties in the JINGLE sample. We investigate the relation between T and beta and other global galaxy properties in the JINGLE and Herschel Reference Survey (HRS) sample. We find that beta correlates with the stellar mass surface density (R=0.62) and anti-correlates with the HI mass fraction (M(HI)/M*, R=-0.65), whereas the dust temperature correlates strongly with the SFR normalized by the dust mass (R=0.73). These relations can be used to estimate T and beta in galaxies with insufficient photometric data available to measure them directly through SED fitting.
JINGLE is a new JCMT legacy survey designed to systematically study the cold interstellar medium of galaxies in the local Universe. As part of the survey we perform 850um continuum measurements with ...SCUBA-2 for a representative sample of 193 Herschel-selected galaxies with M*>10^9Msun, as well as integrated CO(2-1) line fluxes with RxA3m for a subset of 90 of these galaxies. The sample is selected from fields covered by the Herschel-ATLAS survey that are also targeted by the MaNGA optical integral-field spectroscopic survey. The new JCMT observations combined with the multi-wavelength ancillary data will allow for the robust characterization of the properties of dust in the nearby Universe, and the benchmarking of scaling relations between dust, gas, and global galaxy properties. In this paper we give an overview of the survey objectives and details about the sample selection and JCMT observations, present a consistent 30 band UV-to-FIR photometric catalog with derived properties, and introduce the JINGLE Main Data Release (MDR). Science highlights include the non-linearity of the relation between 850um luminosity and CO line luminosity, and the serendipitous discovery of candidate z>6 galaxies.
Inflammation and macrophage foam cells are characteristic features of atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to inflammation and LXR-dependent response pathways ...are poorly understood. To investigate this relationship, we utilized lipidomic and transcriptomic methods to evaluate the effect of diet and LDL receptor genotype on macrophage foam cell formation within the peritoneal cavities of mice. Foam cell formation was associated with significant changes in hundreds of lipid species and unexpected suppression, rather than activation, of inflammatory gene expression. We provide evidence that regulated accumulation of desmosterol underlies many of the homeostatic responses, including activation of LXR target genes, inhibition of SREBP target genes, selective reprogramming of fatty acid metabolism, and suppression of inflammatory-response genes, observed in macrophage foam cells. These observations suggest that macrophage activation in atherosclerotic lesions results from extrinsic, proinflammatory signals generated within the artery wall that suppress homeostatic and anti-inflammatory functions of desmosterol.
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► Desmosterol is the dominant LXR ligand formed in macrophage foam cells ► Desmosterol integrates cholesterol and fatty acid homeostasis in the macrophage ► Desmosterol inhibits activation of inflammatory responses in macrophages ► Macrophage activation in atherosclerosis is likely due to extrinsic mediators
Cholesterol accumulation in peritoneal macrophages results in unexpected suppression, rather than activation, of inflammatory gene expression, suggesting that this response is suppressed in atherosclerotic lesions by extrinsic proinflammatory signals.
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the ...temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.
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•Longitudinal glioma evolution follows an IDH mutation-dependent trajectory•Hypermutation and CDKN2A deletions underlie increased proliferation at recurrence•Recurrent IDH-wild-type neoplastic cells up-regulate neuronal signaling programs•Mesenchymal transitions associate with distinct myeloid cell interactions
Integrating longitudinal transcriptomic and genomic data from paired diffuse glioma samples with complementary single-cell RNA-seq and multiplex immunofluorescence datasets reveals recurrence-associated genetic and microenvironmental changes that are dependent on IDH mutation status.
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N terminus of the Huntingtin protein (HTT). Reactive microglia and elevated cytokine ...levels are observed in the brains of HD patients, but the extent to which neuroinflammation results from extrinsic or cell-autonomous mechanisms in microglia is unknown. Using genome-wide approaches, we found that expression of mutant Huntingtin (mHTT) in microglia promoted cell-autonomous pro-inflammatory transcriptional activation by increasing the expression and transcriptional activities of the myeloid lineage-determining factors PU.1 and C/EBPs. We observed elevated levels of PU.1 and its target genes in the brains of mouse models and individuals with HD. Moreover, mHTT-expressing microglia exhibited an increased capacity to induce neuronal death ex vivo and in vivo in the presence of sterile inflammation. These findings suggest a cell-autonomous basis for enhanced microglia reactivity that may influence non-cell-autonomous HD pathogenesis.
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