Blended learning combines online digital resources with traditional classroom activities and enables students to attain higher learning performance through well-defined interactive strategies ...involving online and traditional learning activities. Learning analytics is a conceptual framework and as a part of our Precision education used to analyze and predict students' performance and provide timely interventions based on student learning profiles. This study applied learning analytics and educational big data approaches for the early prediction of students' final academic performance in a blended Calculus course. Real data with 21 variables were collected from the proposed course, consisting of video-viewing behaviors, out-of-class practice behaviors, homework and quiz scores, and after-school tutoring. This study applied principal component regression to predict students' final academic performance. The experimental results show that students' final academic performance could be predicted when only one-third of the semester had elapsed. In addition, we identified seven critical factors that affect students' academic performance, consisting of four online factors and three traditional factors. The results showed that the blended data set combining online and traditional critical factors had the highest predictive performance.
One quarter of the global population is estimated to have nonalcoholic fatty liver disease (NAFLD). The incidence of nonalcoholic steatohepatitis (NASH) is projected to increase by up to 56% in the ...next 10 years. NAFLD is already the fastest growing cause of hepatocellular carcinoma (HCC) in the USA, France and the UK. Globally, the prevalence of NAFLD-related HCC is likely to increase concomitantly with the growing obesity epidemic. The estimated annual incidence of HCC ranges from 0.5% to 2.6% among patients with NASH cirrhosis. The incidence of HCC among patients with non-cirrhotic NAFLD is lower, approximately 0.1 to 1.3 per 1,000 patient-years. Although the incidence of NAFLD-related HCC is lower than that of HCC of other aetiologies such as hepatitis C, more people have NAFLD than other liver diseases. Urgent measures that increase global awareness and tackle the metabolic risk factors are necessary to reduce the impending burden of NAFLD-related HCC. Emerging evidence indicates that reduced immune surveillance, increased gut inflammation and gut dysbiosis are potential key steps in tumorigenesis. In this Review, we discuss the global epidemiology, projections and risk factors for NAFLD-related HCC, and propose preventive strategies to tackle this growing problem.
Previous studies of geometric and morphologic parameters of intracranial aneurysms have been conducted to determine rupture risk, which remains incompletely defined due to patient-specific risk ...factors, such as sex, hypertension, and age. To this end, we compared characteristics of ruptured and unruptured aneurysms in the same patients with symmetric bilateral intracranial aneurysms.
Between January 2008 and March 2014, 2361 patients with 2674 aneurysms were diagnosed by CT angiography or surgical findings at 4 medical centers. Geometric and morphologic parameters examined for symmetric bilateral intracranial aneurysms comprised aneurysm wall regularity, size, neck width, aspect ratio, size ratio, neck-to-parent artery ratio, and area ratio. Univariate and multivariate statistical analyses were performed to determine independent risk factors for rupture.
Sixty-three patients (48 women, 15 men; mean age, 62.5 ± 9.8 years) with symmetric bilateral aneurysms were eligible for the study and were included. The most frequent aneurysm location was the posterior communicating artery. Univariate analysis disclosed that aneurysm size, aspect ratio, size ratio, area ratio, and irregular wall differed between patients with ruptured and unruptured aneurysms. Multivariate analysis indicated that aspect ratio of ≥1.6 (adjusted OR, 9.521; 95% CI, 2.182-41.535), area ratio of ≥1.5 (adjusted OR, 4.089; 95% CI, 1.247-13.406), and irregular shape (adjusted OR, 10.443; 95% CI 3.394-32.135) were significant predictive factors for aneurysm rupture after adjustment for aneurysm size.
An aspect ratio of ≥1.6, area ratio of ≥1.5, and irregular wall are associated with aneurysm rupture independent of aneurysm size and patient characteristics. These characteristics alone can help in distinguishing ruptured bilateral intracranial aneurysms from unruptured ones.
This paper presents a novel 400 to 12 V isolated bidirectional dc-dc converter based on a phase-shift-controlled-modified dual-active-bridge power stage. The proposed converter consists of a ...half-bridge and center tap with active clamp circuit, which has promising performance for low-voltage high-current applications. 650 V gallium-nitride high electron mobility transistors are used on the high voltage side to avoid issues encountered using Si superjunction MOSFETs in phase-shift-controlled-bidirectional power conversions. The operation principle and power transfer characteristic are obtained based on a time-domain analysis of the inductor current. Design methodology and criteria and converter's efficiency analysis are discussed. Both the analysis and experiments verify that the proposed converter is capable of achieving low power loss and high power density in soft-switching and hard-switching modes. Experimental results are presented for a 1-kW, 400 V-to-12 V dc-dc prototype converter operating at 100 kHz switching frequency. A power density of 30 W/in 3 and a peak efficiency of 98.3% in a wide input/output voltage range are achieved.
Summary
Although several epidemiological studies reported that maternal chronic hepatitis C virus (HCV) infection had significantly increased risk of undergoing adverse obstetrical and perinatal ...outcomes, studies on the relationship between HCV infection and risk of preterm birth (PTB) have yielded inconclusive and inconsistent results. Therefore, we conducted a meta‐analysis to investigate the association between HCV infection and PTB. The electronic database was searched until 1 September 2014. Relevant studies reporting the association between HCV infection and the risk of PTB were included for further evaluation. Statistical analysis was performed using revmen 5.3 and stata 10.0. Nine studies involving 4186698 participants and 5218 HCV infection cases were included. A significant association between HCV infection and PTB was observed (odds ratio = 1.62, 95% CI 1.48–1.76, P < 0.001, fixed‐effects model). Stratification according to maternal smoking/alcohol abuse, maternal drug abuse or coinfected with HBV and/or HIV matched groups still demonstrated that women with HCV infection had a high risk for PTB. Findings from our meta‐analysis suggested that maternal HCV infection was significantly associated with an increased risk of PTB. In the future, pathophysiological studies are warranted to ascertain the causality and explore the possible biological mechanisms involved.
Iron selenide superconductors exhibit a number of unique characteristics that are helpful for understanding the mechanism of superconductivity in high-Tc iron-based superconductors more generally. ...However, in the case of AxFe2Se2 (A = K, Rb, Cs), the presence of an intergrown antiferromagnetic insulating phase makes the study of the underlying physics problematic. Moreover, FeSe-based systems intercalated with alkali metal ions, NH3 molecules or organic molecules are extremely sensitive to air, which prevents the further investigation of their physical properties. It is therefore desirable to find a stable and easily accessible FeSe-based superconductor to study its physical properties in detail. Here, we report the synthesis of an air-stable material, (Li0.8Fe0.2)OHFeSe, which remains superconducting at temperatures up to ~40 K, by means of a novel hydrothermal method. The crystal structure is unambiguously determined by a combination of X-ray and neutron powder diffraction and nuclear magnetic resonance. Moreover, antiferromagnetic order is shown to coexist with superconductivity. This synthetic route opens a path for exploring superconductivity in other related systems, and confirms the appeal of iron selenides as a platform for understanding superconductivity in iron pnictides more broadly.
Highlights • Our results show that minocycline reduces hypoxia-induced increases in BBB permeability and HIF-1α. • Minocycline also increases the hypoxia-induced reduction of PHD-2 and SIRT-3. • ...These effects of minocycline are abolished by siRNA-mediated knockdown of SIRT-3 in the brain. • Minocycline inhibits HIF-1α-mediated cellular responses and protects the BBB through a SIRT-3/PHD-2-dependent pathway.
A novel distributed power management scheme is proposed in this paper for a DC microgrid system, which is enabled by Solid-State transformer (SST). The proposed system includes distributed renewable ...energy resource (DRER) and distributed energy storage device (DESD). The proposed distributed control algorithm, which only relies on the local information and guarantees full utilization of each module in the system based on their characteristics, is applied to both SST and DC microgrid. To this end, a simulation platform is developed in MATLAB/Simulink, in which Photovoltaic (PV), fuel cell and battery are selected as the typical DRERs and DESD, respectively. Lastly, several typical case studies are carried out and the simulation results verify the proposed distributed power management.
Chronic hepatitis B virus (HBV) infection affects about 296 million people worldwide and is the leading aetiology of cirrhosis and liver cancer globally. Major medical complications also include ...acute flares and extrahepatic manifestations. In addition, people living with HBV infection also experience stigma. HBV-related cirrhosis resulted in an estimated 331,000 deaths in 2019, and it is estimated that the number of deaths from HBV-related liver cancer in 2019 was 192,000, an increase from 156,000 in 2010. Meanwhile, HBV remains severely underdiagnosed and effective measures that can prevent infection and disease progression are underutilized. Birth dose coverage for HBV vaccines remains low, particularly in low-income countries or regions where HBV burden is high. Patients with HBV infection are inadequately evaluated and linked to care and are undertreated worldwide, even in high-income countries or regions. Despite the goal of the World Health Organization to eliminate viral hepatitis as a public health problem by 2030, the annual global deaths from HBV are projected to increase by 39% from 2015 to 2030 if the status quo remains. In this Review, we discuss the current status and future projections of the global burden of HBV infection. We also discuss gaps in the current care cascade and propose future directions.
The solid-state transformer (SST) is an interface device between ac distribution grids and dc distribution systems. The SST consists of a cascaded multilevel ac/dc rectifier stage, a dual active ...bridge (DAB) converter stage with high-frequency transformers to provide a regulated 400-V dc distribution, and an optional dc/ac stage that can be connected to the 400-V dc bus to provide residential 120/240 V _{\rm ac} . However, due to dc-link voltage and power unbalance in the cascaded modules, the unbalanced dc-link voltages and power increase the stress of the semiconductor devices and cause overvoltage or overcurrent issues. This paper proposes a new voltage and power balance control for the cascaded H-Bridge converter-based SST. Based on the single-phase dq model, a novel voltage and the power control strategy is proposed to balance the rectifier capacitor voltages and the real power through parallel DAB modules. Furthermore, the intrinsic power constraints of the cascaded H-Bridge voltage balance control are derived and analyzed. With the proposed control methods, the dc-link voltage and the real power through each module can be balanced. The SST switching model simulation and the prototype experiments are presented to verify the performance of the proposed voltage and power balance controller.
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