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  • Regulatory T cells in autoi... Regulatory T cells in autoimmune disease
    Dominguez-Villar, Margarita; Hafler, David A Nature immunology, 07/2018, Volume: 19, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    In recent years, the understanding of regulatory T cell (T cell) biology has expanded considerably. Key observations have challenged the traditional definition of T cells and have provided insight ...
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  • The plasticity of human Tre... The plasticity of human Treg and Th17 cells and its role in autoimmunity
    Kleinewietfeld, Markus; Hafler, David A Seminars in immunology, 11/2013, Volume: 25, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Highlights • Human CD4+ T cells can display a high grade of plasticity. • Th17 cells can adapt Th1- and Th2-type phenotypes. • FoxP3+ Tregs can differentiate into Th1- and Th17-like cells. • These ...
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  • Prospects of immune checkpo... Prospects of immune checkpoint modulators in the treatment of glioblastoma
    Preusser, Matthias; Lim, Michael; Hafler, David A ... Nature reviews. Neurology, 09/2015, Volume: 11, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Glioblastoma is the most common primary brain tumour in adults. Prognosis is poor: even with the current gold-standard first-line treatment—maximal safe resection and combination of radiotherapy with ...
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  • Pervasive sharing of geneti... Pervasive sharing of genetic effects in autoimmune disease
    Cotsapas, Chris; Voight, Benjamin F; Rossin, Elizabeth ... PLoS genetics, 08/2011, Volume: 7, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Genome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory ...
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  • scNAT: a deep learning meth... scNAT: a deep learning method for integrating paired single-cell RNA and T cell receptor sequencing profiles
    Zhu, Biqing; Wang, Yuge; Ku, Li-Ting ... Genome Biology, 12/2023, Volume: 24, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Many deep learning-based methods have been proposed to handle complex single-cell data. Deep learning approaches may also prove useful to jointly analyze single-cell RNA sequencing (scRNA-seq) and ...
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  • Regulatory T cells in autoi... Regulatory T cells in autoimmune neuroinflammation
    Kleinewietfeld, Markus; Hafler, David A. Immunological reviews, 20/May , Volume: 259, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Summary Regulatory T cells are the central element for the maintenance of peripheral tolerance. Several subtypes of regulatory T (Treg) cells have been described, and most of them belong to the CD4+ ...
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  • Identification of T helper ... Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease
    Dominguez-Villar, Margarita; Baecher-Allan, Clare M; Hafler, David A Nature medicine, 06/2011, Volume: 17, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    CD4(+)CD25(high)CD127(low/-) forkhead box p3 (Foxp3)(+) regulatory T cells (T(reg) cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (T(H)1)-like, ...
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  • Fingolimod for multiple sclerosis
    Pelletier, Daniel; Hafler, David A The New England journal of medicine, 01/2012, Volume: 366, Issue: 4
    Journal Article
    Peer reviewed
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  • FOXP3 + regulatory T cells ... FOXP3 + regulatory T cells in the human immune system
    Sakaguchi, Shimon; Hafler, David A; Miyara, Makoto ... Nature reviews. Immunology, 07/2010, Volume: 10, Issue: 7
    Journal Article
    Peer reviewed

    Forkhead box P3 (FOXP3)(+) regulatory T (T(Reg)) cells are potent mediators of dominant self tolerance in the periphery. But confusion as to the identity, stability and suppressive function of human ...
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  • Fine-mapping the genetic as... Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
    Patsopoulos, Nikolaos A; Barcellos, Lisa F; Hintzen, Rogier Q ... PLoS genetics, 11/2013, Volume: 9, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been ...
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