•CAIPI - Extensible platform for cardiac image processing and analysis.•Open plugin and interaction concept and a spatio-temporal data management for cardiovascular image data.•Application of the ...software platform is illustrated for four practical research cases in the field of image acquisition and processing. Additionally, examples are presented of how our platform is used by applied clinical researchers.
Cardiovascular imaging is an exponentially growing field with aspects ranging from image acquisition and analysis to disease characterization, and evaluation of therapy approaches.The transfer of innovative new technological and algorithmic solutions into clinical practice is still slow. In addition to the verification of solutions, their integration in the clinical processing workflow must be enabled for the assessment of clinical impact and risks. The goal of our software platform for cardiac image processing – CAIPI – is to support researchers from different specialties such as imaging physics, computer science, and medicine by a common extensible platform to address typical challenges and hurdles in interdisciplinary cardiovascular imaging research. It provides an integrated solution for method comparison, integrated analysis, and validation in the clinical context. The interface concept enables a combination with existing frameworks that address specific aspects of the pipeline, such as modeling (e.g., OpenCMISS, CARP) or image reconstruction (Gadgetron).
In our platform, we developed a concept for import, integration, and management of cardiac image data. The integration approach considers the spatiotemporal properties of the beating heart through a specific data model. The solution is based on MeVisLab and provides functionalities for data retrieval and storage. Two types of plugins can be added. While ToolPlugins usually provide processing algorithms such as image correction and segmentation, AnalysisPlugins enable interactive data exploration and reporting. GUI integration concepts are presented for both plugin types. We developed domain-specific reporting and visualization tools (e.g., AHA segment model) to enable validation studies by clinical experts. The platform offers plugins for calculating and reporting quantitative parameters such as cardiac function, which can be used to, e.g., evaluate the effect of processing algorithms on clinical parameters. Export functionalities include quantitative measurements to Excel, image data to PACS, and STL models to modeling and simulation tools.
To demonstrate the applicability of this concept both for method development and clinical application, we present use cases representing different problems along the innovation chain in cardiac MR imaging.
Validation of an image reconstruction method (MRI T1 mapping)
Validation of an image correction method for real-time 2D-PC MRI
Comparison of quantification methods for blood flow analysis
Training and integration of machine learning solutions with expert annotations
Clinical studies with new imaging techniques (flow measurements in the carotid arteries and peripheral veins as well as cerebral spinal fluid).
The presented platform can be used in interdisciplinary teams, in which engineers or data scientists perform the method validation, followed by clinical research studies in patient collectives. The demonstrated use cases show how it enables the transfer of innovations through validation in the cardiovascular application context.
Cerebral venous thrombosis (CVT) affects venous hemodynamics and can provoke severe stroke and chronic intracranial hypertension. We sought to comprehensively analyze 3-dimensional blood flow and ...hemodynamic alterations during acute CVT including collateral recruitment and at follow-up.
Twenty-two consecutive patients with acute CVT were prospectively included and underwent routine brain magnetic resonance imaging (MRI) and 4-dimensional flow MRI at 3 T for the in vivo assessment of cerebral blood flow. Neurological and MRI follow-up at 6 months was performed in 18 patients.
Three-dimensional blood flow visualization and quantification of large dural venous sinuses and deep cerebral veins was successfully performed in all patients. During acute CVT, we observed abnormal flow patterns including stagnant flow, flow acceleration in stenoses, and change of flow directions. In patients with complete recanalization, flow trajectories resembled those known from previously published 4-dimensional flow MRI data in healthy adults. There was a trend toward a relationship between occluded segments and cerebral lesions (not significant). Furthermore, patients with versus without cerebral lesions showed increased mean (0.08±0.09 versus 0.005±0.014 m/s) and peak velocities (0.18±0.21 versus 0.006±0.02 m/s) within partially thrombosed left and right transverse sinuses (
<0.05) at baseline.
Four-dimensional flow MRI was successfully applied for the 3-dimensional visualization and quantification of venous hemodynamics in patients with CVT and provided new dynamic information regarding vessel recanalization. This technique seems promising to investigate the contribution of hemodynamic parameters and collaterals in a larger cohort to identify those at risk of stroke.
. This study assesses age-related differences of thoracic aorta blood flow profiles and provides age- and sex-specific reference values using 4D flow cardiovascular magnetic resonance (CMR) data.
. ...126 volunteers (age 20-80 years, female 51%) underwent 4D flow CMR and 12 perpendicular analysis planes in the thoracic aorta were specified. For these planes the following parameters were evaluated: body surface area-adjusted aortic area (
'), normalized flow displacement (NFD), the degree of wall parallelism (WPD), the minimal relative cross-sectional area through which 80% of the volume flow passes (A80) and the angle between flow direction and centerline (
).
. Age-related differences in blood flow parameters were seen in the ascending aorta with higher values for NFD and angle and lower values for WPD and A80 in older subjects. All parameters describing blood flow patterns correlated with the cross-sectional area in the ascending aorta. No relevant sex-differences regarding blood flow profiles were found.
. These age- and sex-specific reference values for quantitative parameters describing blood flow within the aorta might help to study the clinical relevance of flow profiles in the future.
To achieve the best treatment of mitral valve disease in a patient, surgeons aim to optimally combine complementary surgical techniques. Image‐based in silico simulation as well as visualization of ...the mitral valve dynamics can support the visual analysis of the patient‐specific valvular dynamics and enable an exploration of different therapy options. The usage in a time‐constrained clinical environment requires a mitral valve model that is cost‐effective, easy to set up, parameterize and evaluate. Working towards this goal, we develop a simplified model of the mitral valve and analyse its applicability for the sketched use‐case. We propose a novel approach to simulate the mitral valve with position‐based dynamics. The resulting mitral valve model can be deformed to simulate the closing and opening, and incorporate changes caused by virtual interventions in the simulation. Ten mitral valves were reconstructed from transesophageal echocardiogram sequences of patients with normal and abnormal physiology for evaluation. Simulation results showed good agreements with expert annotations of the original image data and reproduced valve closure in all cases. In four of five pathological cases, abnormal closing behaviour was correctly reproduced. In future research, we aim to improve the parameterization of the model in terms of biomechanical correctness and perform a more extensive validation.
We develop a simplified Position‐based Dynamics model of the mitral valve and analyze its applicability for simulating valve closure and repair procedures in a clinical decision support scenario. A time‐constrained clinical environment requires simulation models that are accurate, cost‐effective, interactive, easy to set up, parameterize, and evaluate.
The aim of this study was to compare aortic flow patterns in patients after David valve-sparing aortic root replacement with physiologically shaped sinus prostheses or conventional tube grafts in ...healthy volunteers.
Twelve patients with sinus prostheses (55 ± 15 years), 6 patients with tube grafts (58 ± 12 years), 12 age-matched, healthy volunteers (55 ± 6 years), and 6 young, healthy volunteers (25 ± 3 years) were examined with time-resolved 3-dimensional magnetic resonance phase contrast imaging (4D Flow MRI). Primary and secondary helical, as well as vortical flow patterns, were evaluated. Aortic arch anatomy as a flow influencing factor was determined.
Compared with volunteers, both sinus prostheses and tube grafts developed more than 4 times as many secondary flow patterns in the ascending aorta (sinus prostheses n = 1.6 ± 0.8; tube grafts n = 1.3 ± 0.6; age-matched, healthy volunteers n = 0.3 ± 0.5; young, healthy volunteers n = 0; P ≤ .012) associated with a kinking of the prosthesis itself or at its distal anastomosis. As opposed to round aortic arches in volunteers (n = 16/18), cubic or gothic-shaped arches predominated in patients (n = 16/18, P < .001). In all but 3 volunteers, 2 counter-rotating helices were confirmed in the ascending aorta and were defined as a primary flow pattern. This primary flow pattern did not develop in patients who underwent valve-sparing aortic root replacement.
In patients after valve-sparing aortic root replacement, there was an increased number of secondary flow patterns in the ascending aorta. This seems to be related to surgically altered aortic geometry with kinking. Because flow alterations are known to affect wall shear stress, there seems to be an increased risk for vessel wall remodeling. Compared with previous 4D Flow MRI studies, primary flow patterns in the ascending aorta in healthy subjects were confirmed to be more complex. This underlines the importance of thorough examination of 4D Flow MRI data.
Many heart diseases can result in reduced pumping capacity of the heart muscle. A mismatch between ATP demand and ATP production of cardiomyocytes is one of the possible causes. Assessment of the ...relation between myocardial ATP production (MV
) and cardiac workload is important for better understanding disease development and choice of nutritional or pharmacologic treatment strategies. Because there is no method for measuring MV
in vivo, the use of physiology-based metabolic models in conjunction with protein abundance data is an attractive approach.
We developed a comprehensive kinetic model of cardiac energy metabolism (CARDIOKIN1) that recapitulates numerous experimental findings on cardiac metabolism obtained with isolated cardiomyocytes, perfused animal hearts, and in vivo studies with humans. We used the model to assess the energy status of the left ventricle of healthy participants and patients with aortic stenosis and mitral valve insufficiency. Maximal enzyme activities were individually scaled by means of protein abundances in left ventricle tissue samples. The energy status of the left ventricle was quantified by the ATP consumption at rest (MV
rest), at maximal workload (MV
max), and by the myocardial ATP production reserve, representing the span between MV
(rest) and MV
(max).
Compared with controls, in both groups of patients, MV
(rest) was increased and MV
(max) was decreased, resulting in a decreased myocardial ATP production reserve, although all patients had preserved ejection fraction. The variance of the energetic status was high, ranging from decreased to normal values. In both patient groups, the energetic status was tightly associated with mechanic energy demand. A decrease of MV
(max) was associated with a decrease of the cardiac output, indicating that cardiac functionality and energetic performance of the ventricle are closely coupled.
Our analysis suggests that the ATP-producing capacity of the left ventricle of patients with valvular dysfunction is generally diminished and correlates positively with mechanical energy demand and cardiac output. However, large differences exist in the energetic state of the myocardium even in patients with similar clinical or image-based markers of hypertrophy and pump function. Registration: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT03172338 and NCT04068740.
Aortic stiffness is associated with a higher incidence of cardiovascular events including stroke. The primary aim of this study was to evaluate whether increased pulse wave velocity (PWV), a marker ...of stiffness, is an independent predictor of aortic atheroma. The secondary aim was to test whether increased PWV reinforces retrograde blood flow from the descending aorta (DAo), a mechanism of stroke.
We performed a cross-sectional case-control study with prospective data acquisition. In all, 40 stroke and 60 ophthalmic patients matched for age and cardiovascular risk factors were included. Multicontrast magnetic resonance imaging (MRI) protocol of the aorta tailored to allow a detailed plaque analysis using 3-dimensional (D) T1-weighted bright blood, T2-weighted and proton density-weighted black blood, and hemodynamic assessment using 4D flow MRI was applied. Individual PWV was calculated based on 4D flow MRI data using the time-to-foot of the blood flow waveform. The extent of maximum retrograde blood flow from the proximal DAo into the arch was quantified.
PWV was higher in stroke patients compared with controls (7.62±2.59 vs. 5.96±2.49 m/s; P=0.005) and in patients with plaques (irrespective of thickness) compared with patients without plaques (7.47±2.89 vs. 5.62±1.89 m/s; P=0.002). Increased PWV was an independent predictor of plaque prevalence and contributed significantly to a predictor model explaining 36.5% (Nagelkerke R2) of the variance in plaque presence. Maximum retrograde flow extent from the proximal DAo was not correlated with PWV.
Aortic stiffness was higher in stroke patients and associated with a higher prevalence of plaques. Increased PWV was an independent predictor of plaque presence. Accordingly, regional PWV seems to be a valuable biomarker for the assessment and management of aortic atherosclerosis. However, no association was found for increased retrograde flow extent from the DAo.