Pulmonary tuberculosis is a chronic infectious disease of the respiratory system. It is still one of the leading causes of death from a single infectious disease, but it has been stuck in the study ...of a single pathogen. Recent studies have shown that many diseases are associated with disruption of the native microbiota. In this study we investigated the occurrence of tuberculosis and the correlation between drug resistance and respiratory flora. High-throughput 16 S rRNA gene sequencing was used to characterize the respiratory microbiota composition of 30 tuberculosis (TB) affected patients and compared with 30 healthy (H) controls. According to their Gene Xpert results, 30 pulmonary tuberculosis patients were divided into 12 persons in the drug-sensitive group (DS0) and 18 persons in the drug-resistant group (DR0). The microbial flora of the two were compared with the H group.
The data generated by sequencing showed that Firmicutes, Proteus, Bacteroides, Actinomyces and Fusobacterium were the five main bacterial phyla detected, and they constituted more than 96% of the microbial community. The relative abundances of Fusobacterium, Haemophilus, Porphyromonas, Neisseria, TM7, Spirochetes, SR1, and Tenericutes in the TB group was lower than that of the H group, and Granulicatella was higher than the H group. The PcoA diagrams of the two groups had obvious clustering differences. The Alpha diversity of the TB group was lower than that of the H group, and the Beta diversity was higher than that of the H group (P < 0.05). The relative abundance of Streptococcus in the DS0 group was significantly higher than that in the DR0 group (P < 0.05).
Pulmonary tuberculosis can cause disorders of the respiratory tract microbial flora, in which the relative abundance of Streptococcus was significantly different between rifampicin-sensitive and rifampicin-resistant patients.
Bifunctional photocatalytic nanofiltration (PNF) membrane has become a reliable frontier technique for removing refractory organic micropollutants. However, the active mitigated fouling mechanism ...from the microscopic perspective during its long-term operation of purifying real micro-polluted water is rarely studied. Herein, with an integrated use of QSense Explorer and confocal laser scanning microscope techniques, self-cleaning foulant attachment on an activated and customized near-infrared responsive polymeric PNF (termed as nPNF) membrane with good service performance for continuous dynamic removing antibiotics in sewage effluent environment was firstly elucidated. Time-dependent changes in dissipation oscillation frequency, sensed mass and the visualized foulant spatial distribution all indicated that there were only sporadic foulant attachment, an extremely low fouling layer thickness and irreversible fouling rate on/of the activated nPNF membrane top surface, thereby endowing it with excellent self-cleaning characteristic. This is probably because the reactive oxygen species (mainly •O2- and •OH) concurrently destroys the integrity of fouling layer and its internal adhesion structure, transforming part of the irreversible fouling on nPNF membrane surface into reversible one that is easy to wash off. These new horizons provided useful insight on the fate of selected antibiotics in the to-be-removed stage and self-cleaning foulant attachment of PNF membrane.
Cathode materials mixture (LiFePO
4
/C and acetylene black) is recycled and regenerated by using a green and simple process from spent lithium iron phosphate batteries (noted as S-LFPBs). Recovery ...cathode materials mixture (noted as Recovery-LFP) and Al foil were separated according to their density by direct pulverization without acid/alkali leaching for the first time. Subsequently, Recovery-LFP is further directly regenerated with solid state reaction and reused for lithium ion battery without adding acetylene black at the first time. Compared with recovery material, regeneration cathode materials mixture (noted as regeneration-LFP) displays excellent electrochemical performances, which delivers a discharge capacity of 129.43 mAh g
−1
in the first and maintains 120.32 mAh g
−1
with a high capacity retention rate of 92.96% after 1000 cycles at 0.5C through 18,650 battery testing. It is concluded that the regeneration material can be reused as cathode materials for lithium batteries.
Three-dimensionally (3D) layers nanosheets of MoS
2
(3DLN-MoS
2
) were successfully prepared by the lithium intercalation-exfoliation of
n
-butylithium to bulk MoS
2
. It is the first time to use ...3DLN-MoS
2
film prepared by electrostatic spray deposition (ESD) directly as the anode materials for rechargeable lithium-ion batteries without any conductive additive and binder. By the analyses of X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), it’s found that MoS
2
were exfoliated and stacked together to form a 3D structure. Compared to that of commercial MoS
2
, this special three-dimensional structure results in high rate transportation of electrolyte ion and electrons throughout the electrode matrix. After ten cycles at 0.1 and 1000 cycles at 2 A/g, the discharging capacity was 1204.5 and 569.1 mAh g
−1
, achieving an excellent rate capacity and a good cycling stability.
Allergic asthma is a chronic lung disease characterized by wheezing, coughing, chest tightness and shortness of breath. Clinically, the treatments against asthma focus on controlling the symptoms ...rather than inhibiting recurrence radically. Additionally, local and systemic side effects caused by current treatments are worthy of attention. Therefore, a novel therapeutic strategy against asthma is needed. Asatone is a pharmacologically active component from Radix et Rhizoma Asari, which has anti-inflammatory effects in lipopolysaccharide-induced lung injury. In the present study, we showed that asatone could protect mice against OVA-induced asthma, as manifested by attenuating inflammation infiltration, mucus production, and airway hyperreactivity and suppressing the elevation of IL-4, IL-5, and IL-13 in broncho-alveolar lavage fluid. Overall, results of the present study support use of asatone as a potent therapeutic strategy for clinical treatment of allergic asthma.
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