Table of contents I1: Trauma, Pre-hospital and Cardiac Arrest Care 2015 Pascale Avery, Leopold Salm, Flora Bird A1: Retrospective evaluation of HEMS 'Direct to CT' protocol Anja Hutchinson, Ashley ...Matthies, Anthony Hudson, Heather Jarman A2 Rush hour - Crush hour: temporal relationship of cyclist vs. HGV trauma admissions. A single site observational study Maria Bergman Nilsson, Tom Konig, Nigel Tai A3 Semiprone position endotracheal intubation during continuous cardiopulmonary resuscitation in drowned children with regurgitation: a case report and experimental manikin study Espen Fevang, Barge Hognestad, H#195;#165;kon B. Abrahamsen A4 An audit of CO2 A-a gradient in non-trauma patients receiving pre-hospital anaesthesia Olivia V Cheetham, Matthew JC Thomas, Kieron D Rooney A5 Can the use of c-spine immobilisation collars be avoided in non-trauma patients presenting to the Emergency Department? Josephine Murray, Malcolm Tunnicliff A6 Curriculum mapping in ED point of care simulation Joseph W Collinson, Thomas Brown, Christopher Pritchett A7 Point of care multidisciplinary trauma team simulation participant satisfaction in a geographically remote trauma unit in Cornwall Christopher SA Pritchett, Mark Jadav, Gareth Meredith, Jamie Plumb, Steve Harris, Roger Langford A8 Conservative management of head injury inpatients - the challenge of simplifying injury management in a non-neurosurgical hospital JG Hunter, A Sage, R Madden, O Flamank, B Broadbent, S Marsh, H Lewis, E Daniels, N Roberts A9 Improving the care of traumatic brain injury at non-neurosurgical hospitals: Introducing a head injury pathway and single place of care is associated with significant improvements in neurological observation JG Hunter, A Sage, R Madden, O Flamank, B Broadbent, S Marsh, H Lewis, E Daniels, N Lin, N Roberts A10 The experience of inter-disciplinary students undertaking cardiac arrest moulage training Samuel Bulford, Silas Houghton-Budd, Sam Pearson, Megan Clear-Hill A11 Impact brain apnoea - nine cases David J Menzies, James P Leonard, Conor Keogh, Ray Quinn, John D Hinds A12 Time well spent? Improving the performance improvement programme in a busy Trauma Unit N Roberts, D Ashton-Cleary, M Jadav A14 Clinical significant and outcome of pulmonary contusions in patients with blunt chest trauma Ismail Mahmood, Ayman El-Menyar, Basil Younis, Ahmed Khalid, Syed Nabir, Mohamed Nadeem Ahmed, Omer Al-Yahri, Hassan Al-Thani A15 Plastics operative workload in major trauma centres: a national prospective survey Katie Young, Susan A. Hendrickson, Georgina Phillips, Matthew D. Gardiner, Shehan Hettiaratchy A16 A survey to assess the accuracy of estimating height by pre-hospital clinicians: can we reliably predict those most at risk of serious injury? Alexandra Alice Crossland, Anthony Hudson A17 An audit of the cause, outcome and adherence to treatment Standard Operating Procedure (SOP) for all traumatic cardiac arrests at a Helicopter Emergency Medical Service over a 12-month period Nicholas C Brassington, Anthony Hudson, Emily McWhirter A18 Should we "stay-and-play? A study of patient physiology in Norwegian Helicopter Emergency Services Bjarn O Reid, Marius Rehn, Oddvar Uleberg, Andreas J Kr#252;ger A19 Training in resuscitative thoracotomy: have we cracked it? A survey of higher Emergency Medicine trainees in London Cara Jennings, Yasmin Kapadia, Duncan Bew A20 London's Air Ambulance (LAA): 25-years of drownings in an urban environment Jenny Townsend, Tom P Hurst, Elizabeth A Foster A21 Live patients in trauma simulation - more than just simulation on a shoestring? Thomas B Brown, Joseph Collinson, Christopher Pritchett, Toby Slade A22 Collecting core data in pre-hospital critical care using a consensus based template Kristin Tansager, Marius Rehn, Kjetil G.Ringdal, Andreas J.Kr#252;ger A23 Prehospital interventions before and after implementation of a physician staffed helicopter Rasmus Hesselfeldt, Sandra Wulffeld, Asger Sonne, Lars S. Rasmussen, Jacob Steinmetz A24 Duration of ventilation following prehospital drug assisted intubation; a retrospective review Thomas J Renninson, Nadine Thomson, Harvey Pynn, Timothy J Hooper A25 Non-haemorrhagic shock in trauma: a novel guideline for management in ED Anthony Hudson, Jacinta Dawson, Ashley Matthies A26 Patient-tailored triage decisions by anaesthetist-staffed pre-hospital critical care teams Morten Langfeldt Friberg, Leif Rogn#195;#165;s A27 Anatomical accuracy and appropriate sizing of pre-hospital thoracostomies Jessica FG Wills, Anthony Hudson A28 Pre-hospital management of mass casualty civilian shootings Conor DA Turner, Marius Rehn A30 The prevalence of alcohol-related trauma recidivism: a systematic review James Nunn, Mete Erdogan, Robert S. Green A31 Development of a hospital-wide program for simulation-based training in trauma care and management Samuel Minor, Mete Erdogan, Kathy Hartlen, Robert S. Green A32 Out of Hospital Cardiac Arrests (OOHCA); lessons from Hollywood Ruth Bird, Rachael L. Grupping A33 Mechanism of injury as a predictor of severity of injury in road traffic collisions: a literature review Amelia M. Stacey, Marius Rehn, David J. Lockey A34 Lessons to be learned from prehospital airway intervention documentation? Are airway intervention documentation templates as successful in-hospital as prehospitally? S. Abiks, L. Cutler, K. Monaghan, A. Al-Rais, C. Hymers, R. Bloomer, Y. Kapadia A35 Novel biomarkers in prehospital management of traumatic brain injury (the PreTBI study protocol) Sophie-Charlott Seidenfaden, Ingunn S. Riddervold, Hans Kirkegaard, Niels Juul, Morten T. Batker A36 Hospital outcomes of traumatic railway incidents: a seven-year observational retrospective study of a major trauma centre Alice Gao, Zane Perkins; Gareth Grier, Alex Tzannes A37 Does taking a third crew member affect the on-scene time of HEMS jobs? Nathan Hudson-Peacock, Quentin Otto, Laurie Phillipson, Rik Thomas, Ainsley Heyworth A38 Does pre-hospital rapid sequence induction affect on-scene time of HEMS jobs? Quentin Otto, Nathan Hudson-Peacock, Laurie Phillipson, Ainsley Heyworth, Erica Ley A39 Code red: shock index as a prehospital indicator of massive haemorrhage Daniel Banner, Ainsley Heyworth, Erica Ley A40 Air ambulance tasking: how accurate are our current methods? Madeleine Benson, Nathan Hudson-Peacock, Tony Stone, Erica Ley, Louise Rousson, Ainsley Heyworth A41 Modern trauma burden in a district general hospital Beth A Lineham, Matthew J Lee, Martin Gough A42 Establishing a legal service for major trauma patients in two UK major trauma centres William H Seligman, Hannah E Thould, Andrew Dinsmore, Charlotte Tan, Julian Thompson, C Andy Eynon, David J Lockey A43 Prehospital assessment and care of patients - a study of the use of guidelines when assessing head trauma Rebecka M Rubenson Wahlin, Veronica Lindstr#246;m, Sari Ponzer, Veronica Vicente A44 An audit of pre-hospital blood pressure management resulting from head injury Pamela Eligio, Anthony Hudson A45 The surgical contribution of surface shading volumetric rendering techniques in rib fracture management Robert Young, Dimitri Amiras, Ian Sinha
London Trauma Conference 2015 : London, UK, 8-11 December 2015 Avery, Pascale; Salm, Leopold; Bird, Flora ...
Scandinavian journal of trauma, resuscitation and emergency medicine,
2016-Jun-17, 2016-6-17, 20160617, Volume:
24 Suppl 1, Issue:
S1
Journal Article
Peer reviewed
Open access
I1: Trauma, Pre-hospital and Cardiac Arrest Care 2015
Pascale Avery, Leopold Salm, Flora Bird
A1: Retrospective evaluation of HEMS ‘Direct to CT’ protocol
Anja Hutchinson, Ashley Matthies, Anthony ...Hudson, Heather Jarman
A2 Rush hour – Crush hour: temporal relationship of cyclist vs. HGV trauma admissions. A single site observational study
Maria Bergman Nilsson, Tom Konig, Nigel Tai
A3 Semiprone position endotracheal intubation during continuous cardiopulmonary resuscitation in drowned children with regurgitation: a case report and experimental manikin study
Espen Fevang, Børge Hognestad, Håkon B. Abrahamsen
A4 An audit of CO2 A-a gradient in non-trauma patients receiving pre-hospital anaesthesia
Olivia V Cheetham, Matthew JC Thomas, Kieron D Rooney
A5 Can the use of c-spine immobilisation collars be avoided in non-trauma patients presenting to the Emergency Department?
Josephine Murray, Malcolm Tunnicliff
A6 Curriculum mapping in ED point of care simulation
Joseph W Collinson, Thomas Brown, Christopher Pritchett
A7 Point of care multidisciplinary trauma team simulation & participant satisfaction in a geographically remote trauma unit in Cornwall
Christopher SA Pritchett, Mark Jadav, Gareth Meredith, Jamie Plumb, Steve Harris, Roger Langford
A8 Conservative management of head injury inpatients - the challenge of simplifying injury management in a non-neurosurgical hospital
JG Hunter, A Sage, R Madden, O Flamank, B Broadbent, S Marsh, H Lewis, E Daniels, N Roberts
A9 Improving the care of traumatic brain injury at non-neurosurgical hospitals: Introducing a head injury pathway and single place of care is associated with significant improvements in neurological observation
JG Hunter, A Sage, R Madden, O Flamank, B Broadbent, S Marsh, H Lewis, E Daniels, N Lin, N Roberts
A10 The experience of inter-disciplinary students undertaking cardiac arrest moulage training
Samuel Bulford, Silas Houghton-Budd, Sam Pearson, Megan Clear-Hill
A11 Impact brain apnoea – nine cases
David J Menzies, James P Leonard, Conor Keogh, Ray Quinn, John D Hinds
A12 Time well spent? Improving the performance improvement programme in a busy Trauma Unit
N Roberts, D Ashton-Cleary, M Jadav
A14 Clinical significant and outcome of pulmonary contusions in patients with blunt chest trauma
Ismail Mahmood, Ayman El-Menyar, Basil Younis, Ahmed Khalid, Syed Nabir, Mohamed Nadeem Ahmed, Omer Al-Yahri, Hassan Al-Thani
A15 Plastics operative workload in major trauma centres: a national prospective survey
Katie Young, Susan A. Hendrickson, Georgina Phillips, Matthew D. Gardiner, Shehan Hettiaratchy
A16 A survey to assess the accuracy of estimating height by pre-hospital clinicians: can we reliably predict those most at risk of serious injury?
Alexandra Alice Crossland, Anthony Hudson
A17 An audit of the cause, outcome and adherence to treatment Standard Operating Procedure (SOP) for all traumatic cardiac arrests at a Helicopter Emergency Medical Service over a 12-month period
Nicholas C Brassington, Anthony Hudson, Emily McWhirter
A18 Should we “stay-and-play? A study of patient physiology in Norwegian Helicopter Emergency Services
Bjørn O Reid, Marius Rehn, Oddvar Uleberg, Andreas J Krüger
A19 Training in resuscitative thoracotomy: have we cracked it? A survey of higher Emergency Medicine trainees in London
Cara Jennings, Yasmin Kapadia, Duncan Bew
A20 London’s Air Ambulance (LAA): 25-years of drownings in an urban environment
Jenny Townsend, Tom P Hurst, Elizabeth A Foster
A21 Live patients in trauma simulation – more than just simulation on a shoestring?
Thomas B Brown, Joseph Collinson, Christopher Pritchett, Toby Slade
A22 Collecting core data in pre-hospital critical care using a consensus based template
Kristin Tønsager, Marius Rehn, Kjetil G.Ringdal, Andreas J.Krüger
A23 Prehospital interventions before and after implementation of a physician staffed helicopter
Rasmus Hesselfeldt, Sandra Wulffeld, Asger Sonne, Lars S. Rasmussen, Jacob Steinmetz
A24 Duration of ventilation following prehospital drug assisted intubation; a retrospective review
Thomas J Renninson, Nadine Thomson, Harvey Pynn, Timothy J Hooper
A25 Non-haemorrhagic shock in trauma: a novel guideline for management in ED
Anthony Hudson, Jacinta Dawson, Ashley Matthies
A26 Patient-tailored triage decisions by anaesthetist-staffed pre-hospital critical care teams
Morten Langfeldt Friberg, Leif Rognås
A27 Anatomical accuracy and appropriate sizing of pre-hospital thoracostomies
Jessica FG Wills, Anthony Hudson
A28 Pre-hospital management of mass casualty civilian shootings
Conor DA Turner, Marius Rehn
A30 The prevalence of alcohol-related trauma recidivism: a systematic review
James Nunn, Mete Erdogan, Robert S. Green
A31 Development of a hospital-wide program for simulation-based training in trauma care and management
Samuel Minor, Mete Erdogan, Kathy Hartlen, Robert S. Green
A32 Out of Hospital Cardiac Arrests (OOHCA); lessons from Hollywood
Ruth Bird, Rachael L. Grupping
A33 Mechanism of injury as a predictor of severity of injury in road traffic collisions: a literature review
Amelia M. Stacey, Marius Rehn, David J. Lockey
A34 Lessons to be learned from prehospital airway intervention documentation? Are airway intervention documentation templates as successful in-hospital as prehospitally?
S. Abiks, L. Cutler, K. Monaghan, A. Al-Rais, C. Hymers, R. Bloomer, Y. Kapadia
A35 Novel biomarkers in
pre
hospital management of
t
raumatic
b
rain
i
njury (the PreTBI study protocol)
Sophie-Charlott Seidenfaden, Ingunn S. Riddervold, Hans Kirkegaard, Niels Juul, Morten T. Bøtker
A36 Hospital outcomes of traumatic railway incidents: a seven-year observational retrospective study of a major trauma centre
Alice Gao, Zane Perkins; Gareth Grier, Alex Tzannes
A37 Does taking a third crew member affect the on-scene time of HEMS jobs?
Nathan Hudson-Peacock, Quentin Otto, Laurie Phillipson, Rik Thomas, Ainsley Heyworth
A38 Does pre-hospital rapid sequence induction affect on-scene time of HEMS jobs?
Quentin Otto, Nathan Hudson-Peacock, Laurie Phillipson, Ainsley Heyworth, Erica Ley
A39 Code red: shock index as a prehospital indicator of massive haemorrhage
Daniel Banner, Ainsley Heyworth, Erica Ley
A40 Air ambulance tasking: how accurate are our current methods?
Madeleine Benson, Nathan Hudson-Peacock, Tony Stone, Erica Ley, Louise Rousson, Ainsley Heyworth
A41 Modern trauma burden in a district general hospital
Beth A Lineham, Matthew J Lee, Martin Gough
A42 Establishing a legal service for major trauma patients in two UK major trauma centres
William H Seligman, Hannah E Thould, Andrew Dinsmore, Charlotte Tan, Julian Thompson, C Andy Eynon, David J Lockey
A43 Prehospital assessment and care of patients – a study of the use of guidelines when assessing head trauma
Rebecka M Rubenson Wahlin, Veronica Lindström, Sari Ponzer, Veronica Vicente
A44 An audit of pre-hospital blood pressure management resulting from head injury
Pamela Eligio, Anthony Hudson
A45 The surgical contribution of surface shading volumetric rendering techniques in rib fracture management
Robert Young, Dimitri Amiras, Ian Sinha
Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide ...association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes.
We did two separate genome-wide association studies (GWAS) and a meta-analysis of pulmonary arterial hypertension. These GWAS used data from four international case-control studies across 11 744 individuals with European ancestry (including 2085 patients). One GWAS used genotypes from 5895 whole-genome sequences and the other GWAS used genotyping array data from an additional 5849 individuals. Cross-validation of loci reaching genome-wide significance was sought by meta-analysis. Conditional analysis corrected for the most significant variants at each locus was used to resolve signals for multiple associations. We functionally annotated associated variants and tested associations with duration of survival. All-cause mortality was the primary endpoint in survival analyses.
A locus near SOX17 (rs10103692, odds ratio 1·80 95% CI 1·55–2·08, p=5·13 × 10–15) and a second locus in HLA-DPA1 and HLA-DPB1 (collectively referred to as HLA-DPA1/DPB1 here; rs2856830, 1·56 1·42–1·71, p=7·65 × 10–20) within the class II MHC region were associated with pulmonary arterial hypertension. The SOX17 locus had two independent signals associated with pulmonary arterial hypertension (rs13266183, 1·36 1·25–1·48, p=1·69 × 10–12; and rs10103692). Functional and epigenomic data indicate that the risk variants near SOX17 alter gene regulation via an enhancer active in endothelial cells. Pulmonary arterial hypertension risk variants determined haplotype-specific enhancer activity, and CRISPR-mediated inhibition of the enhancer reduced SOX17 expression. The HLA-DPA1/DPB1 rs2856830 genotype was strongly associated with survival. Median survival from diagnosis in patients with pulmonary arterial hypertension with the C/C homozygous genotype was double (13·50 years 95% CI 12·07 to >13·50) that of those with the T/T genotype (6·97 years 6·02–8·05), despite similar baseline disease severity.
This is the first study to report that common genetic variation at loci in an enhancer near SOX17 and in HLA-DPA1/DPB1 is associated with pulmonary arterial hypertension. Impairment of SOX17 function might be more common in pulmonary arterial hypertension than suggested by rare mutations in SOX17. Further studies are needed to confirm the association between HLA typing or rs2856830 genotyping and survival, and to determine whether HLA typing or rs2856830 genotyping improves risk stratification in clinical practice or trials.
UK NIHR, BHF, UK MRC, Dinosaur Trust, NIH/NHLBI, ERS, EMBO, Wellcome Trust, EU, AHA, ACClinPharm, Netherlands CVRI, Dutch Heart Foundation, Dutch Federation of UMC, Netherlands OHRD and RNAS, German DFG, German BMBF, APH Paris, INSERM, Université Paris-Sud, and French ANR.
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