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  • Phosphorylation of seryl-tR... Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis
    Shi, Yi; Liu, Ze; Zhang, Qian ... PLoS biology, 12/2020, Volume: 18, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Hypoxia-induced angiogenesis maintains tissue oxygen supply and protects against ischemia but also enhances tumor progression and malignancy. This is mediated through activation of transcription ...
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  • Molecular and chemical gene... Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish
    Sasaki, Tomoyuki; Kishi, Shuji Biochimica et biophysica acta, 09/2013, Volume: 1832, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    The incidence of diseases increases rapidly with age, accompanied by progressive deteriorations of physiological functions in organisms. Aging-associated diseases are sporadic but mostly inevitable ...
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  • Double mimicry evades tRNA ... Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
    Song, Youngzee; Zhou, Huihao; Vo, My-Nuong ... Nature communications, 12/2017, Volume: 8, Issue: 1
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    Peer reviewed
    Open access

    Hundreds of non-proteinogenic (np) amino acids (AA) are found in plants and can in principle enter human protein synthesis through foods. While aminoacyl-tRNA synthetase (AARS) editing potentially ...
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  • The muscle-specific ubiquit... The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
    Hanai, Jun-ichi; Cao, Peirang; Tanksale, Preeti ... The Journal of clinical investigation, 12/2007, Volume: 117, Issue: 12
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    Open access

    Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and are widely used to treat hypercholesterolemia. These drugs can lead to a number of side effects in muscle, including ...
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  • Cognitive aging in zebrafish Cognitive aging in zebrafish
    Yu, Lili; Tucci, Valter; Kishi, Shuji ... PloS one, 12/2006, Volume: 1, Issue: 1
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    Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the ...
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  • The identification of zebra... The identification of zebrafish mutants showing alterations in senescence-associated biomarkers
    Kishi, Shuji; Bayliss, Peter E; Uchiyama, Junzo ... PLOS genetics, 08/2008, Volume: 4, Issue: 8
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    There is an interesting overlap of function in a wide range of organisms between genes that modulate the stress responses and those that regulate aging phenotypes and, in some cases, lifespan. We ...
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  • Aberrant autolysosomal regu... Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency
    Sasaki, Tomoyuki; Lian, Shanshan; Qi, Jie ... PLOS genetics, 06/2014, Volume: 10, Issue: 6
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    Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect ...
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  • Zebrafish as a genetic mode... Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review
    Kishi, Shuji; Slack, Barbara E; Uchiyama, Junzo ... Gerontology, 07/2009, Volume: 55, Issue: 4
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    Peer reviewed
    Open access

    Understanding the molecular mechanisms of aging in vertebrates is a major challenge of modern biology and biomedical science. This is due, in part, to the complexity of the aging process and its ...
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