Familial forms of small-vessel vasculitis has been reported in 14 families (including this one).
A father and son were both diagnosed with renal vasculitis (pauci-immune crescentic ...glomerulonephritis). Both had antimyeloperoxidase autoantibodies, and there was no evidence of a common environmental factor.
These cases suggest the role of constitutional factors in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis.
