This paper is concerned with the transformed parameter-dependent
H
∞
controller design for semi-Markovian jump linear parameter varying (S-MJLPV) systems under actuator saturation and faults. In the ...S-MJLPV system, the semi-Markov process transition rate is time-varying during the semi-Markov process and a plant includes time-varying parameters which are bounded and measurable in magnitude. For more practical analysis and synthesis of the S-MJLPV systems, a time-varying actuator fault model and actuator saturation of the controller are considered into account simultaneously. The primary goal of this paper is to develop a transformed parameter-dependent control that makes the closed-loop system stochastically stable with
H
∞
performance index
γ
and provides less conservative results against actuator saturation and faults. Based on the mode-dependent Lyapunov function, new sufficient conditions are obtained to ensure that the stochastic stability of S-MJLPV systems. Eventually, an example based on the turbofan-engine model is presented to demonstrate the efficacy of our proposed methods.
This paper deals the problem of integral sliding mode control using decoupled disturbance compensator for discrete-time systems with mismatched disturbances. The proposed method allows the ...disturbance compensation to be modified separately from the control input, since the two inputs of system are completely decoupled. In the developed method, the actual disturbance is estimated by the decoupled disturbance compensator (DDC) method to design the control input and stabilize the system. Integral sliding mode control with DDC scheme minimizes the control effort and improves the system performance. Main advantage of this method is to eliminate the reaching phase and reduce the control effort, simultaneously. Finally, simulation results are shown to demonstrate the usefulness of the presented methodology.
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular ...cells within the brain that are proposed as SARS-CoV-2 infection points. Here we show that pericyte-like cells (PLCs), when integrated into a cortical organoid, are capable of infection with authentic SARS-CoV-2. Before infection, PLCs elicited astrocytic maturation and production of basement membrane components, features attributed to pericyte functions in vivo. While traditional cortical organoids showed little evidence of infection, PLCs within cortical organoids served as viral 'replication hubs', with virus spreading to astrocytes and mediating inflammatory type I interferon transcriptional responses. Therefore, PLC-containing cortical organoids (PCCOs) represent a new 'assembloid' model that supports astrocytic maturation as well as SARS-CoV-2 entry and replication in neural tissue; thus, PCCOs serve as an experimental model for neural infection.
This paper presents a new parallel distributed compensation controller design approach for T-S (Takagi-Sugeno) fuzzy control systems with affine matched membership functions in the system and ...controller. In the new fuzzy control, affine transformed membership functions are adopted by scaling and biasing the original membership functions of the system. Stabilization and performance criterion of the closed-loop T-S fuzzy systems are obtained through a new parameterized linear matrix inequality, which is rearranged by affine matched membership functions. The conservativeness of stabilization condition for the T-S fuzzy system is significantly relaxed by utilizing the constraints condition of the controllers membership functions, which is determined from the difference of each transformed membership function. In addition, the controller gain is reconstructed by a decision variable separation technique with two different free weighting matrices without any scaling parameter. The superiority of proposed method is verified through numerical examples.
In this study, a field survey was conducted on the fixed anchorages of the operation and power generation facilities installed in domestic power plants. A static/dynamic performance evaluation was ...conducted to present safety evaluation guidelines that meet the domestic seismic performance requirements. Seismic performance tests were performed on the post-installed set anchors M10 and M12, which are mainly used for anchorages in accordance with the US and European seismic performance standards. The dynamic shear test results showed that the M12 anchor met the seismic performance verification criterion, whereas the M10 anchor did not because its dynamic performance was reduced, owing to the cyclic loading. In the results of the dynamic pull-out test, M12 also met the seismic performance verification criterion, whereas M10 was safe only in a non-cracked state. In summary, the seismic performance of M12 in both cracks and non-cracks was satisfied, but, in the case of M10, the results were not satisfied in cracks. This was an experimental study; it will be necessary to conduct additional analytical research in the future to verify the reliability and parameters of the experiment.
Notably, there was a recent case report on abatacept treatment in an adult with idiopathic autoimmune enteropathy.7 To investigate the molecular effect of the drug, we sampled the patient's blood at ...the trough level (ie, 0 day) and at 1, 4, 6, and 8 days (among these, samples from the trough level and days 4 and 8 were subjected to the fluorescence-activated cell sorting analysis) after the administration of the drug (Fig 2, A-D; for drug treatment details, see the Methods section in this article's Online Repository at www.jacionline.org). Here we report a direct effect of CTLA-4 dysfunction in human; enhancing the CTLA-4-mediated signal with CTLA-4-Ig toned down immune responses in a patient with severe autoimmune features, eventually achieving substantial clinical improvements. ...it would be worthwhile to investigate patients with idiopathic autoimmune features for additional CTLA-4 mutations that may affect proper protein function and use CTLA-4-Ig as a potential therapeutic solution.
In this paper, the non-static error tracking control issue for the networked control system is considered. First, the unstable modes of the external disturbance signal and the output signal of the ...reference system are established to form a new series system with the controlled objects. Then, an internal model compensation controller is presented to achieve non-static tracking error. Furthermore, an adaptive event-triggering mechanism is introduced as a communication method to improve network resource utilization. By formulating the tracking control problem of the networked control system as the stabilization problem of a time-varying time-delay system, a sufficient condition such that the closed-loop system is asymptotically stable and satisfies the H∞ output tracking performance is derived. Finally, the simulation examples illustrate the feasibility and effectiveness of the proposed approach.
In this study, the structural integrity of a system installed on protrusion concrete, considering the usability of a vertical hydrogen storage vessel, was verified. To achieve this, a site survey was ...conducted to select the target structure, and analytical validation was performed to design specimens for shaking table tests. Subsequently, dynamic behavior characteristics were analyzed using an artificial earthquake simulated according to the procedures outlined in ICC-ES AC 156, which is the seismic design criterion. As a result, it was observed that the seismic motion was amplified by approximately 10 times compared to the original load magnitude, based on the acceleration response of the test specimen. It is inferred that the seismic motion occurring during an earthquake could cause significant damage to both the internal and external aspects of the structure, depending on the structure’s form and the composition of materials. Through analytical verification and testing, it was revealed that the main structure of the test specimen and the anchor bolts for installation met the seismic performance criteria. However, the protrusion concrete area exhibited damage, indicating a structural vulnerability when subjected to external forces such as earthquakes. Consequently, on-site measures to address this structural risk need to be explored.
Despite efforts to interrogate human genome variation through large-scale databases, systematic preference toward populations of Caucasian descendants has resulted in unintended reduction of power in ...studying non-Caucasians. Here we report a compilation of coding variants from 1,055 healthy Korean individuals (KOVA; Korean Variant Archive). The samples were sequenced to a mean depth of 75x, yielding 101 singleton variants per individual. Population genetics analysis demonstrates that the Korean population is a distinct ethnic group comparable to other discrete ethnic groups in Africa and Europe, providing a rationale for such independent genomic datasets. Indeed, KOVA conferred 22.8% increased variant filtering power in addition to Exome Aggregation Consortium (ExAC) when used on Korean exomes. Functional assessment of nonsynonymous variant supported the presence of purifying selection in Koreans. Analysis of copy number variants detected 5.2 deletions and 10.3 amplifications per individual with an increased fraction of novel variants among smaller and rarer copy number variable segments. We also report a list of germline variants that are associated with increased tumor susceptibility. This catalog can function as a critical addition to the pre-existing variant databases in pursuing genetic studies of Korean individuals.
This paper deals with the synchronization of fuzzy neural networks (FNNs) with time-varying delays. FNNs are more complicated form of neural networks incorporated with fuzzy logics, which provide ...more powerful performances. Especially, the problem of delayed FNNs's synchronization is of importance in the existence of the network communication. For the synchronization of FNNs with time-varying delays, a novel form of control structure is proposed employing affinely transformed membership functions with memory element. In accordance with affine memory control, appropriate Lyapunov-Krasovskii functional is chosen to design control gain, guaranteeing stability of the systems with delays. Exploiting the more general type of control attributed by affine transformation and memory-type, a novel criterion is derived in forms of linear matrix inequalities (LMIs). As a results, the effectiveness of the proposed control is shown through numerical examples by comparisons with others.
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