The adsorption performances of amino-functionalized Zr-based metal-organic tetrahedron (ZrT-1-NH2) for sulfachloropyridazine (SCP) in aqueous solution were first reported.
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An ...amino-functionalized Zr-based metal–organic tetrahedron (denoted as ZrT-1-NH2) was synthesized under solvothermal conditions. In addition, the adsorption performances of ZrT-1-NH2 for sulfachloropyridazine (SCP) from aqueous solution were investigated. Moreover, the experimental results revealed that ZrT-1-NH2 has adsorption performance for SCP. The adsorption kinetic data were best fitted with the pseudo second order model. Furthermore, a plausible adsorption mechanism was proposed.
The fretting wear behavior of fluorine rubber (FKM) and short carbon fiber (SCF) reinforced fluorine rubber matrix composites (SCF/FKMCs) is investigated experimentally under air condition. Four ...kinds of SCF/FKMCs with different SCF concentrations (5 phr, 10 phr, 15 phr, and 20 phr in every 100 phr of FKM) are considered. The contact model utilizes the sphere-on-flat contact between a 440 C stainless steel ball and an FKM or SCF/FKMCs coating perfectly bonded to a ceramic sheet in fretting experiments. The impacts of SCF concentration, normal force, and displacement amplitude on the fretting wear behavior are investigated. Scanning electron microscope (SEM) is used to analyze the fretting wear surface morphology and wear mechanism, while three-dimensional (3D) white-light interference profilometer is used to describe the characteristics of 3D surface wear profile and determine the wear volume. The fretting wear performances of FKM and SCF/FKMCs with different SCF concentrations are compared under different fretting test conditions. The results show that adding an appropriate amount of SCFs to FKM can improve wear resistance and reduce the coefficient of friction (COF). SCF/FKMC with SCF concentration of 15 phr has the smallest COF. SCF/FKMCs with SCF concentration of 5 phr or 15 phr have the best wear resistance for small normal force or large displacement amplitude.
Chemotherapy drugs exerts beneficial antitumor activity before and after cancer surgery. Post-injury complications are a potential hazard after surgical tumor resection. Inflammation caused by ...surgical stress is known to promote the progression of post-injury complications. Recent studies have found that chemotherapy drugs can promote post-injury inflammatory response, leading to increased post-injury complications. Imidazole derivatives have effective anticancer activity. However, the impact of post-operative inflammation caused by imidazole derivatives is unclear. In this study, two novel phenanthroimidazole derivatives (L082 and L142) were synthesized and characterized. These compounds showed significant inhibitory effects on different tumor cells. The compound L082 also inhibited liver cancer in vivo. In addition, L082 played a significant role in inhibiting the accumulation of inflammatory cells and promoting the elimination of inflammatory cells at the incision, which may be related to inhibiting the production of ROS and NO in oxidative and nitric stress. These results suggest that L082 can be used as a bifunctional drug to suppress tumors and reduce post-injury inflammation complications.
: Advanced pancreatic cancer (APC) is a fatal disease with limited treatment options. This study aims to evaluate the effectiveness and safety of different Chinese herbal injections (CHIs) as ...adjuvants for radiotherapy (RT) in APC and compare their treatment potentials using network meta-analysis.
: We systematically searched three English and four Chinese databases for randomized controlled trials (RCTs) from inception to July 25, 2023. The primary outcome was the objective response rate (ORR). Secondary outcomes included Karnofsky performance status (KPS) score, overall survival (OS), and adverse events (AEs). The treatment potentials of different CHIs were ranked using the surface under the cumulative ranking curve (SUCRA). The Cochrane RoB 2 tool and CINeMA were used for quality assessment and evidence grading.
: Eighteen RCTs involving 1199 patients were included. Five CHIs were evaluated. Compound Kushen injection (CKI) combined with RT significantly improved ORR compared to RT alone (RR 1.49, 95% CrI 1.21-1.86). Kanglaite (KLT) plus RT (RR 1.58, 95% CrI 1.20-2.16) and CKI plus RT (RR 1.49, 95% CrI 1.16-1.95) were associated with improved KPS score compared to radiation monotherapy, with KLT+RT being the highest rank (SUCRA 72.28%). Regarding AEs, CKI plus RT was the most favorable in reducing the incidence of leukopenia (SUCRA 90.37%) and nausea/vomiting (SUCRA 85.79%).
: CKI may be the optimal choice of CHIs to combine with RT for APC as it may improve clinical response, quality of life, and reduce AEs. High-quality trials are necessary to establish a robust body of evidence.
PROSPERO, CRD42023396828.
The development of Ru(ii) complexes as luminescent probes has attracted increasing attention in recent decades. In this study, the nanosized polymers of two Ru(ii) complexes Ru(phen)
(dppz)(ClO
)
(1, ...phen = 1,10-phenanthrolin; dppz = dipyrido3,2-
:2',3'-
phenazine) and Ru(phen)
(Br-dppz)(ClO
)
(2, Br-dppz = 11-bromodipyrido3,2-
:2',3'-
phenazine) with oligonucleotides were prepared and investigated as potential tumor-imaging probes. The formation of the nanosized polymers, which had an average width of 125-438 nm and an average height of 3-6 nm, for 1 and 2@oligonucleotides were observed through atomic force microscopy. The emission spectra indicated that the luminescence of 1 and 2 markedly increased after binding to oligonucleotides and double-strand DNA (calf thymus DNA), respectively. Moreover, further studies indicated that 1@oligonucleotides and 2@oligonucleotides can easily enter into tumor cells and selectively highlight the tumor area in the zebrafish bear xenograft tumor (MDA-MB-231). In summary, this study demonstrated that 1@oligonucleotides and 2@oligonucleotides could be developed as potential tumor-imaging luminescent probes for clinical diagnosis and therapy.
Data from EV-D68-infected patients demonstrate that pathological changes in the lower respiratory tract are principally characterized by severe respiratory illness in children and acute flaccid ...myelitis. However, lack of a suitable animal model for EV-D68 infection has limited the study on the pathogenesis of this critical pathogen, and the development of a vaccine. Ferrets have been widely used to evaluate respiratory virus infections. In the current study, we used EV-D68-infected ferrets as a potential animal to identify impersonal indices, involving clinical features and histopathological changes in the upper and lower respiratory tract (URT and LRT). The research results demonstrate that the EV-D68 virus leads to minimal clinical symptoms in ferrets. According to the viral load detection in the feces, nasal, and respiratory tracts, the infection and shedding of EV-D68 in the ferret model was confirmed, and these results were supported by the EV-D68 VP1 immunofluorescence confocal imaging with α2,6-linked sialic acid (SA) in lung tissues. Furthermore, we detected the inflammatory cytokine/chemokine expression level, which implied high expression levels of interleukin (IL)-1a, IL-8, IL-5, IL-12, IL-13, and IL-17a in the lungs. These data indicate that systemic observation of responses following infection with EV-D68 in ferrets could be used as a model for EV-D68 infection and pathogenesis.
ObjectivesOur study aimed to investigate the relationship between the severity of frailty and the long-term care (LTC) needs of older adults from Chinese communities.DesignA cross-sectional ...study.SettingThree Chinese community health centres. All data were collected by trained researchers through face-to-face collection.ParticipantsWe surveyed a total of 540 older residents who aged 60 or older from community in Guangzhou, China.MeasuresThe Chinese version of the Tilburg frailty indicator was used to assess the frailty status of participants. LTC needs was evaluated by Integrated Home Care Services Questionnaire. Using non-adjusted and multivariate adjusted logistic regression analysis to evaluate frailty and LTC needs, then smoothed plots, threshold effect analysis and P for trend were used to further investigate the relationship between them.ResultsThe prevalence of frailty was 45.2% among the 540 older adults enrolled (aged 70.4±8.3 years; 65.7% females). 27% had higher LTC needs, which increased to 65.1% for individuals with frailty. Logistic regression analysis showed that frailty was strongly associated with LTC needs (OR 3.06, 95% CI 2.06 to 4.55, p<0.01). In the multivariate model, after adjusting for demographic characteristics, economic situation, activities of daily living and comorbidities, frailty remained significantly associated with LTC needs (OR 2.32, 95% CI 1.39 to 3.88, p<0.01). The smoothed plots showed a nearly linear relationship between frailty and LTC needs. Threshold effect analysis showed that every point increase in frailty, the score of LTC needs increased 1.3 points. The IQR to regroup individuals with frailty. Compared with the first quartile (scores ≤2), the incidence of LTC needs increased with the frailty status (p value for trend <0.01).ConclusionThere is a linear relationship between frailty and LTC needs. With the increasing degree of frailty, the LTC needs of older adults dramatically increases.
Detecting antibiotics and heavy metal ions in water system are great crucial to protect environment. Two new ternary coordination polymers (CPs), Cd(HBTC)(L)1.5n (1) and {Cd(TBTA)(L)·H2O}n (2) ...(H3BTC = 1,3,5-benzenetricarboxylic acid, H2TBTA = tetrabromoterephthalic acid, and L = 1,4-bis(benzimidazole-2-yl)butane) were prepared under the hydrothermal conditions. 1 possesses a 1D infinite chain which further extended into a 3D supramolecular network through O–H⋯O hydrogen bonding interactions, while 2 exhibits a 3D dia framework. 1 and 2 display excellent thermal and chemical stability. Moreover, Both CPs can be as the difunctional fluorescent sensors with high sensitivity, selectivity, and low limit of detection, which can detect enrofloxacin and Fe3+ (for 1), tetracycline and Cr2O72− ions (for 2) in aqueous solution through the fluorescence quenching effects process.
Display omitted Two new ternary Cd(II) coordination polymers Cd(HBTC)(L)1.5n (1) and {Cd(TBTA)(L)·H2O}n (2) were successfully synthesized. 1 and 2 display excellent thermal and chemical stability. Moreover, Both CPs can be as the difunctional fluorescent sensors with high sensitivity, selectivity, and low limit of detection, which can detect enrofloxacin and Fe3+ (for 1), tetracycline and Cr2O72− ions (for 2) in aqueous solution through the fluorescence quenching effects process.
•Two CPs based on bis(benzimidazole-2-yl)butane ligands were synthesized.•1 can be as a luminescent probe for the detection of enrofloxacin and Fe3+.•2 is a dual-responsive probe for the sensing of tetracycline and Cr2O72−.•The luminescent sensing mechanism was discussed.
Respirovirus infection can cause viral pneumonia and acute lung injury (ALI). The interleukin-1 (IL-1) family consists of proinflammatory cytokines that play essential roles in regulating immune and ...inflammatory responses
. IL-1 signaling is associated with protection against respiratory influenza virus infection by mediation of the pulmonary anti-viral immune response and inflammation. We analyzed the infiltration lung immune leukocytes and cytokines that contribute to inflammatory lung pathology and mortality of fatal H1N1 virus-infected IL-1 receptor 1 (IL-1R1) deficient mice. Results showed that early innate immune cells and cytokine/chemokine dysregulation were observed with significantly decreased neutrophil infiltration and IL-6, TNF-α, G-CSF, KC, and MIP-2 cytokine levels in the bronchoalveolar lavage fluid of infected IL-1R1
mice in comparison with that of wild type infected mice. The adaptive immune response against the H1N1 virus in IL-1R1
mice was impaired with downregulated anti-viral Th1 cell, CD8+ cell, and antibody functions, which contributes to attenuated viral clearance. Histological analysis revealed reduced lung inflammation during early infection but severe lung pathology in late infection in IL-1R1
mice compared with that in WT infected mice. Moreover, the infected IL-1R1
mice showed markedly reduced neutrophil generation in bone marrow and neutrophil recruitment to the inflamed lung. Together, these results suggest that IL-1 signaling is associated with pulmonary anti-influenza immune response and inflammatory lung injury, particularly via the influence on neutrophil mobilization and inflammatory cytokine/chemokine production.
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