One thousand one hundred and fifty-two dual-purpose improved chickens (576 Kuroiler and 576 Sasso) of mixed sexes were reared in two diverse agro-ecological zones, i.e., highland and lowland in ...Mvomero district, Eastern Tanzania, to determine the effects of agro-ecological zones on growth performance, egg production, and survivability under farmer management conditions. Two villages per zone were purposively selected, and from each village, 16 farmers were included in the study; a particular farmer received 18 birds of mixed sexes of the same breed. Data on body weight, egg production trait, and mortality were taken at different ages from week 6 up to 52. General Linear Models fitting breed, agro-ecological zone, and interactions between breed and zone were used to analyze the data. Results show that breed had no significant effects on body weight and body weight gain. However, the effects of the agro-ecological zone and interaction between breed and zone on body weight and body weight gain were significant at the 16th and 20th week of age. The highland zone had heavier chickens than the lowland. While Sasso performed better than Kuroiler chickens in the highland zone, the opposite was observed in the lowland. Significant breed × agro-ecology interactions were observed only for age at first egg whereby Sasso matured earlier than Kuroiler in the highland zone but much later than Kuroiler in the lowland. Birds raised in the highland zone survived better than those chickens in the lowland during both growing and laying periods. Thus, knowledge of breed performance in relation to agro-ecological differences is critical when distributing improved chicken breeds to farmers.
The experiment was conducted to evaluate the effect of breed, diet, and level of feed supplementation on growth performance, feed conversion ratio, and survivability of Sasso and Kuroiler chicken. ...The study was conducted in two separate phases, i.e., the starter phase (0–6 weeks of age) and grower phase (6–20 weeks of age). One thousand sixty–day-old Sasso and Kuroiler chicks were raised until 6 weeks under intensive management system with three dietary treatments. At the age of 6 weeks, a total of 960 birds (480 Sasso and 480 Kuroiler) were randomly selected from each treatment diet and assigned to four feed supplementation levels, i.e., 25%, 50%, 75%, and 100% with two replicates each having 20 birds. Beginning week 7, birds were allowed to semi-scavenge from 6:00 am in the morning to 6:00 pm in the evening with free access to open grass area of 1 bird/4 m
2
. Grower rations based on the three categories, i.e., commercial, medium-cost, and low-cost formulation, were fed from 7th to the 20th week of age. During 0 to 6 weeks of the growing phase, the breed and diet significantly (
p
< 0.05) influenced 6-week live weight, live weight gain, and feed conversion ratio. Birds given commercial diet (D1) excelled in live weight, total live weight gains, and feed conversion ratio followed by medium-cost (D2) and low-cost (D3) diet respectively. During the 7th to 20th weeks of the growing phase, the breed, diet, and supplementation levels had a significant influence (
p
< 0.05) on the live weight and weight gain at 20 weeks of age. Feed cost per kilogram gain increased with an increase in the level of supplementation. Days taken by birds to reach market weight (2 kg) with 100%, 75%, 50%, and 25% level of dietary supplementation were 16, 18, 20, and more than 20 weeks respectively. The survival rate for Sasso and Kuroiler was 99.80% and 97.13% respectively. It is concluded that appreciable growth performance can be attained for semi-scavenging Sasso and Kuroiler chickens when supplemented with medium- or low-cost diets at the level of 50 to 75% of their daily feed requirements.
Sustainable rural food systems for poor and vulnerable people need to be locally adapted to enhance food security. This requires participatory action research that considers the entire food value ...chain (FVC). This paper presents an assessment of the feasibility and potential success of upgrading strategies (UPS) for enhancing food security based on a study that was part of a larger participatory research project in two regions of Tanzania. The authors present the results relating to natural resource management and crop production. The results for natural resources show that enhanced soil water management was rated as high for the semi-arid Dodoma region. For the Morogoro region, the experts favoured soil fertility-improving UPS, such as conservation agriculture and agroforestry. Assessments of food production for both regions indicated the importance of intercropping, manure input, pest and disease control and cover crops. Assessments differed greatly between the two different climatic regions, and to a lesser extent between the nationality of the experts and their gender. This highlights the importance of including different South–North and female–male awareness in assessments. Implementation feasibility assessments of UPS indicated that the most suitable approaches were rainwater harvesting for semi-arid and conservation agriculture for subhumid regions respectively. Local and/or regional stakeholders and experts should be involved in developing and assessing site-adapted UPS for enhancing Tanzanian FVCs.
Enhancing food security for poor and vulnerable people requires adapting rural food systems to various driving factors. Food security-related research should apply participatory action research that ...considers the entire food value chain to ensure sustained success. This article presents a research framework that focusses on determining, prioritising, testing, adapting and disseminating food securing upgrading strategies across the multiple components of rural food value chains. These include natural resources, food production, processing, markets, consumption and waste management. Scientists and policy makers jointly use tools developed for assessing potentials for enhancing regional food security at multiple spatial and temporal scales. The research is being conducted in Tanzania as a case study for Sub-Saharan countries and is done in close collaboration with local, regional and national stakeholders, encompassing all activities across all different food sectors.
•We propose a framework for food security research on rural food value chains.•The framework includes action research with stakeholders of all food sectors.•The research is conducted in Tanzania at multiple spatial and temporal scales.•We prioritize, test and evaluate upgrading strategies for rural food systems.•Scientists and policy-makers jointly assess potentials for enhancing food security.
The outbreak of coronavirus infectious disease-2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world. Several studies ...have shown that detecting SARS-CoV-2 in untreated wastewater can be a useful tool to identify new outbreaks, establish outbreak trends, and assess the prevalence of infections. On 06 May 2021, over a year into the pandemic, we conducted a scoping review aiming to summarize research data on SARS-CoV-2 in sewage. Papers dealing with raw sewage collected at wastewater treatment plants, sewer networks, septic tanks, and sludge treatment facilities were included in this review. We also reviewed studies on sewage collected in community settings such as private or municipal hospitals, healthcare facilities, nursing homes, dormitories, campuses, airports, aircraft, and cruise ships. The literature search was conducted using the electronic databases PubMed, EMBASE, and Web Science Core Collection. This comprehensive research yielded 1090 results, 66 of which met the inclusion criteria and are discussed in this review. Studies from 26 countries worldwide have investigated the occurrence of SARS-CoV-2 in sewage of different origin. The percentage of positive samples in sewage ranged from 11.6 to 100%, with viral concentrations ranging from ˂LOD to 4.6 × 10
8
genome copies/L. This review outlines the evidence currently available on wastewater surveillance: (i) as an early warning system capable of predicting COVID-19 outbreaks days or weeks before clinical cases; (ii) as a tool capable of establishing trends in current outbreaks; (iii) estimating the prevalence of infections; and (iv) studying SARS-CoV-2 genetic diversity. In conclusion, as a cost-effective, rapid, and reliable source of information on the spread of SARS-CoV-2 and its variants in the population, wastewater surveillance can enhance genomic and epidemiological surveillance with independent and complementary data to inform public health decision-making during the ongoing pandemic.
Graphic Abstract
Food security is one of the main goals of rural poor people. To enhance food security in this context, participatory action research can help to ensure sustained success while considering entire food ...value chains (FVC). This paper assesses the feasibility and potential success of upgrading strategies (UPS) as well as their assessment criteria as developed by German and Tanzanian agricultural scientists. The results form part of a larger participatory research project conducted in two climatically representative regions of Tanzania: semi-arid Dodoma and subhumid Morogoro. This paper presents the findings with respect to food processing, waste management and bioenergy, along with income generation and market participation. Assessments on other components of the FVC, including natural resource management, crop production and consumption, are reported by Graef et al (2015). The assessments for food processing revealed preferences for preservation techniques, oil extraction processes and food storage devices for the semi-arid region. In contrast, in the subhumid region, the experts favoured food storage devices and preservation techniques. Assessments of waste management and bioenergy UPS for both regions indicated the importance of animal feed from crop residues, crop residues as mulch and compost from food waste, although with somewhat different priorities. Assessments on income generation and markets in both regions revealed preferences for savings and credit cooperatives and communication techniques, but also indicated that warehouse receipt systems and guarantee systems had a high impact. Assessments differed between the two different climatic regions, and to some extent also between the nationality of experts and their gender. The authors therefore attach importance to integrating different South–North and female–male awareness in assessments among scientists. Moreover, local and/or regional stakeholders and experts should be involved in developing site-adapted UPS for enhancing FVCs.
Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent ...human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries.
Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria. Rotavirus vaccination status was confirmed by review of the vaccine card or clinic records. The risk of intussusception within 1 to 7 days and 8 to 21 days after vaccination among infants 28 to 245 days of age was assessed by means of the self-controlled case-series method.
Data on 717 infants who had intussusception and confirmed vaccination status were analyzed. One case occurred in the 1 to 7 days after dose 1, and 6 cases occurred in the 8 to 21 days after dose 1. Five cases and 16 cases occurred in the 1 to 7 days and 8 to 21 days, respectively, after dose 2. The risk of intussusception in the 1 to 7 days after dose 1 was not higher than the background risk of intussusception (relative incidence i.e., the incidence during the risk window vs. all other times, 0.25; 95% confidence interval CI, <0.001 to 1.16); findings were similar for the 1 to 7 days after dose 2 (relative incidence, 0.76; 95% CI, 0.16 to 1.87). In addition, the risk of intussusception in the 8 to 21 days or 1 to 21 days after either dose was not found to be higher than the background risk.
The risk of intussusception after administration of monovalent human rotavirus vaccine was not higher than the background risk of intussusception in seven lower-income sub-Saharan African countries. (Funded by the GAVI Alliance through the CDC Foundation.).
The combination antimalarial therapy of artemisinin-naphthoquine (ART-NQ) was developed as a single-dose therapy, aiming to improve adherence relative to the multiday schedules of other artemisinin ...combination therapies. The pharmacokinetics of ART-NQ has not been well characterized, especially in children. A pharmacokinetic study was conducted in adults and children over 5 years of age (6 to 10, 11 to 17, and ≥18 years of age) with uncomplicated malaria in Tanzania. The median weights for the three age groups were 20, 37.5, and 55 kg, respectively. Twenty-nine patients received single doses of 20 mg/kg of body weight for artemisinin and 8 mg/kg for naphthoquine, and plasma drug concentrations were assessed at 13 time points over 42 days from treatment. We used nonlinear mixed-effects modeling to interpret the data, and allometric scaling was employed to adjust for the effect of body size. The pharmacokinetics of artemisinin was best described by one-compartment model and that of naphthoquine by a two-compartment disposition model. Clearance values for a typical patient (55-kg body weight and 44.3-kg fat-free mass) were estimated as 66.7 L/h (95% confidence interval CI, 57.3 to 78.5 L/h) for artemisinin and 44.2 L/h (95% CI, 37.9 to 50.6 L/h) for naphthoquine. Nevertheless, we show via simulation that patients weighing ≥70 kg achieve on average a 30% lower day 7 concentration compared to a 48-kg reference patient at the doses tested, suggesting dose increases may be warranted to ensure adequate exposure. (This study has been registered at ClinicalTrials.gov under identifier NCT01930331.).
There is substantial new variation for quantitative traits generated by mutation that can be utilised by artificial selection. With long-term selection, however, response is often attenuated and a ...selection limit sometimes reached, even though genetic variation is frequently still present in these lines. In this paper, the theoretical bases of long-term response and variability of populations that come from mutational variance are reviewed, and the relation between them is related to the strength and mode of the natural selection, whether due to pleiotropic effects of mutant genes or stabilising selection. Simple formulae to predict the consequence of relaxed or reversed selection are derived. Results from long-term selection experiments in mice in this laboratory are described and related to the theoretical analyses with the aim of reconciling the evidence for substantial standing variation with the low rate of response.
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