This paper proposes a distributed coordination control method for multiple bidirectional power converters (BPCs) in a hybrid ac/dc microgrid. The researched hybrid ac/dc microgrid is composed of both ...ac and dc subgrids connected by multiple parallel BPCs, and only the ac subgrid contains storages for the sake of economy. The proposed control method can realize the appropriate power interaction between the two subgrids and make the two subgrids to support each other, so the hybrid microgrid can operate well in both the grid-connected and islanded modes. Concretely, there are three improvements in this proposed control methods. First, a d-q-0 three-axis control strategy instead of the conventional d-q two-axis control strategy is adopted to suppress the circulating current on the ac side generated by the multiple parallel BPCs. And then the square of the dc voltage rather than the dc voltage itself is controlled, which can make the control of the dc voltage linearized and can make the BPCs provide well voltage support for the dc subgrid. Second, the dc droop control is adopted for the dc current sharing. Also, in order to relieve the storages from generating too much reactive power if the ac load reactive power is very large in the ac subgrid, the reactive power droop control is adopted to make the BPCs share some reactive power. Third, taking the capacities and load types of the two subgrids into consideration, a coordinated control strategy based on the dc voltage versus the frequency droop is designed to realize the power interaction between the two subgrids. Furthermore, the stability analysis of the proposed control method is conducted. All the conclusions are verified by the real-time hardware-in-loop tests.
The long-term pulmonary function and related physiological characteristics of COVID-19 survivors have not been studied in depth, thus many aspects are not understood.
COVID-19 survivors were ...recruited for high resolution computed tomography (HRCT) of the thorax, lung function and serum levels of SARS-CoV-2 IgG antibody tests 3 months after discharge. The relationship between the clinical characteristics and the pulmonary function or CT scores were investigated.
Fifty-five recovered patients participated in this study. SARS-CoV-2 infection related symptoms were detected in 35 of them and different degrees of radiological abnormalities were detected in 39 patients. Urea nitrogen concentration at admission was associated with the presence of CT abnormalities (P = 0.046, OR 7.149, 95% CI 1.038 to 49.216). Lung function abnormalities were detected in 14 patients and the measurement of D-dimer levels at admission may be useful for prediction of impaired diffusion defect (P = 0.031, OR 1.066, 95% CI 1.006 to 1.129). Of all the subjects, 47 of 55 patients tested positive for SARS-CoV-2 IgG in serum, among which the generation of Immunoglobulin G (IgG) antibody in female patients was stronger than male patients in infection rehabilitation phase.
Radiological and physiological abnormalities were still found in a considerable proportion of COVID-19 survivors without critical cases 3 months after discharge. Higher level of D-dimer on admission could effectively predict impaired DLCO after 3 months discharge. It is necessary to follow up the COVID-19 patients to appropriately manage any persistent or emerging long-term sequelae.
Key Scientific Research Projects of Henan Higher Education Institutions
In the hybrid ac-dc microgrid, the ac and dc subgrids are connected by bidirectional power converters (BPCs) that play an important role in the load power sharing and power interaction between the ac ...and dc subgrids. The coordination control and circulating current suppression for the parallel BPC system are very challenging. In this paper, a decentralized coordination control method is proposed for parallel three-phase BPCs, which can suppress the circulating currents, realize proper power interaction, and achieve overall load power sharing in both the grid-connected mode and the islanded mode. The performance of the proposed control methods is verified by the real-time hardware-in-loop tests.
Formation of thick, high energy density, flexible solid supercapacitors is challenging because of difficulties infilling gel electrolytes into porous electrodes. Incomplete infilling results in a low ...capacitance and poor mechanical properties. Here we report a bottom-up infilling method to overcome these challenges. Electrodes up to 500 μm thick, formed from multi-walled carbon nanotubes and a composite of poly(3,4-ethylenedioxythiophene), polystyrene sulfonate and multi-walled carbon nanotubes are successfully infilled with a polyvinyl alcohol/phosphoric acid gel electrolyte. The exceptional mechanical properties of the multi-walled carbon nanotube-based electrode enable it to be rolled into a radius of curvature as small as 0.5 mm without cracking and retain 95% of its initial capacitance after 5000 bending cycles. The areal capacitance of our 500 μm thick poly(3,4-ethylenedioxythiophene), polystyrene sulfonate, multi-walled carbon nanotube-based flexible solid supercapacitor is 2662 mF cm
at 2 mV s
, at least five times greater than current flexible supercapacitors.
Adipose tissue is the largest endocrine organ, producing various adipokines and many other substances. Almost all blood vessels are surrounded by perivascular adipose tissue (PVAT), which has not ...received research attention until recently. This review will discuss the paracrine actions of PVAT on the growth of underlying vascular smooth muscle cells (VSMCs). PVAT can release growth factors and inhibitors. Visfatin is the first identified growth factor derived from PVAT. Decreased adiponectin and increased tumour necrosis factor‐α in PVAT play a pathological role for neointimal hyperplasia after endovascular injury. PVAT‐derived angiotensin II, angiotensin 1–7, reactive oxygen species, complement component 3, NO and H2S have a paracrine action on VSMC contraction, endothelial or fibroblast function; however, their paracrine actions on VSMC growth remain to be directly verified. Factors such as monocyte chemoattractant protein‐1, interleukin‐6, interleukin‐8, leptin, resistin, plasminogen activator inhibitor type‐1, adrenomedullin, free fatty acids, glucocorticoids and sex hormones can be released from adipose tissue and can regulate VSMC growth. Most of them have been verified for their secretion by PVAT; however, their paracrine functions are unknown. Obesity, vascular injury, aging and infection may affect PVAT, causing adipocyte abnormality and inflammatory cell infiltration, inducing imbalance of PVAT‐derived growth factors and inhibitors, leading to VSMC growth and finally resulting in development of proliferative vascular disease, including atherosclerosis, restenosis and hypertension. In the future, using cell‐specific gene interventions and local treatments may provide definitive evidence for identification of key factor(s) involved in PVAT dysfunction‐induced vascular disease and thus may help to develop new therapies.
LINKED ARTICLES This article is part of a themed section on Fat and Vascular Responsiveness. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue‐3
Abstract
The circumferential joint of a shield tunnel is prone to damage under strong earthquakes, affecting the safety of the tunnel. This paper adopts an innovative shape memory alloy (SMA) ...flexible circumferential joint for longitudinal seismic mitigation of the tunnel. The SMA joint is composed of SMA ring springs and ordinary bolts. The SMA joint design is performed for a shield tunnel, and a simplified model of the SMA joint is proposed. Based on the generalised response displacement method, the longitudinal seismic mitigation analysis of the tunnel is conducted, the arrangement of SMA joints is discussed, and the seismic mitigation performance is evaluated. Results show that the SMA joint design method can efficiently complete the joint design, and the SMA joint model can accurately reflect the joint performance. SMA joints can reduce the stiffness of tunnel joints and have a good energy dissipation effect, which is suitable for shield tunnel seismic mitigation. An appropriate SMA joint arrangement can concentrate the tunnel joint deformation and effectively reduce the opening width between the tunnel segment rings. It can also dissipate energy and reduce the internal force of the tunnel joint, thus enhancing the seismic safety of the tunnel.
Occupancy mapping is widely used to generate volumetric 3D environment models from point clouds, informing a robotic platform which parts of the environment are free and which are not. The selection ...of the parameters that govern the point cloud generation algorithms and mapping algorithms affects the process and the quality of the final map. Although previous studies have been reported in the literature on optimising major parameter configurations, research in the process to identify optimal parameter sets to achieve best occupancy mapping performance remains limited. The current work aims to fill this gap with a two-step principled methodology that first identifies the most significant parameters by conducting Neighbourhood Component Analysis on all parameters and then optimise those using grid search with the area under the Receiver Operating Characteristic curve. This study is conducted on 20 data sets with specially designed targets, providing precise ground truths for evaluation purposes. The methodology is tested on OctoMap with point clouds created by applying StereoSGBM on the images from a stereo camera. A clear indication can be seen that mapping parameters are more important than point cloud generation parameters. Moreover, up to 15% improvement in mapping performance can be achieved over default parameters.
Background/Aims: Preventing undesirable endothelial-mesenchymal transformation (EnMT) with repetitious in vitro expansion of human corneal endothelial cells (CECs) is a pivotal issue in cornea ...regeneration. Previous studies have shown that inhibition of the TGF-β pathway reduces epithelial-mesenchymal transformation. However, its potential role in EnMT remains poorly understood. As such, the effect of LY2109761, a novel TGF-β receptor type I and type II dual inhibitor, was investigated on EnMT. Methods: CECs cultured with various concentrations of LY2109761 were evaluated for their growth rate and phenotype. Additionally, the expression of functional markers (sodium-potassium pump Na+/K+-ATPase and the tight junction protein ZO-1) and mesenchymal markers (CD73, fibronectin, and vimentin) was detected using immunostaining and western blot. The mRNA expressions were also assayed by real-time polymerase chain reaction analysis. Results: At a 1 μM concentration, LY2109761 did not influence the proliferation of CECs and subsequent experiments were therefore performed using this concentration. Furthermore, CECs cultured in the presence of 1 μM LY2109761 maintained their ability to grow as a monolayer of hexagonal-shaped cells. The expression of functional markers increased in LY2109761-treated CECs, while the expression of mesenchymal markers decreased (both in protein and mRNA levels). Conclusion: Inhibition of TGF-β receptor type I and type II by LY2109761 maintained the phenotype of CECs and inhibited the EnMT process. These results indicate the possible continuous in vitro expansion of CECs with normal function.
The Mid‐to‐Lower Reaches of the Yangtze River (MLRYR) suffered an extreme drought in the post‐monsoon season of 2019, contemporaneous with a strong Central Pacific (CP) El Niño and a super positive ...Indian Ocean Dipole (pIOD) event. The present work shows that CP El Niño‐related Pacific Sea Surface Temperature Anomalies (SSTAs) weakened the western North Pacific anticyclone to prevent moisture transport to the MLRYR and explained 60% of the drought intensity. The super pIOD with an extremely cold SSTA in the tropical Southeastern Indian Ocean contributed 40% of the drought amplitude via an atmospheric teleconnection. The Indian Ocean cold SSTAs first strengthened the post‐monsoon rainfall and enhanced diabatic heating over South Asia, leading to baroclinic circulation anomalies with induced descending motion over the MLRYR. The aggravated dry conditions there ultimately broke the historical drought record for the period since 1979.
Plain Language Summary
In the post‐monsoon season of 2019, the Mid‐to‐Lower Reaches of the Yangtze River (MLRYR) experienced a record‐breaking drought, which severely disrupted water supplies and affected the planting of crops. At the same time, a super positive Indian Ocean Dipole (pIOD) event occurred, along with a central Pacific (CP) El Niño in the tropical Pacific. The present study indicates that in addition to the CP El Niño, the extremely cold SSTAs in the tropical Southeastern Indian Ocean associated with the super pIOD event was also an important factor in the record‐breaking drought event. This factor first shifted the intertropical convergence zone northward to intensify the post‐monsoon rainfall and its released condensation heating over South Asia. Then, a vertically baroclinic circulation was stimulated to strengthen a descending motion over the MLRYR via an atmospheric teleconnection. On the other hand, the tropical Pacific warm SSTAs related to the strong CP El Niño weakened the western North Pacific anticyclone, which reduced the moisture supply to the MLRYR. In this way, both the pIOD and CP El Niño events jointly resulted in the record‐breaking MLRYR drought in 2019 and explained approximately 40% and 60% of this extreme drought, respectively.
Key Points
Drought over the mid‐to‐lower reaches of the Yangtze River (MLRYR) broke historical records in 2019 during the post‐monsoon season
A strong central Pacific El Niño contributed ∼60% of the extreme MLRYR drought intensity due to the tropical Pacific air‐sea interaction
Another 40% of this MLRYR drought can be attributed to a super positive Indian Ocean Dipole via a teleconnection effect over South Asia
Alzheimer's disease (AD) is the most progressive form of neurodegenerative disease, which severely impairs cognitive function. Oxidative stress is identified to contribute to the mechanisms ...responsible for the pathogenesis of such neurodegenerative diseases. Aluminum is a potent neurotoxin for inducing oxidative stress associated with neurodegenerative diseases. The treatment for AD is limited; hence more treatment options are the need of the day. Betalain is known for its multitude of medicinal assets, including anti-inflammatory activity. Hence, this study was intended to investigate the possible protective effect of betalain against aluminum chloride (AlCl3) induced AD on Sprague Dawley (SD) rats. AlCl3 (100 mg/kg) was administrated orally to induce the AD in SD rats. The rats were supplemented with low and high betalain doses (10 mg/kg and 20 mg/kg) for four weeks. At the end of the experiment, the rats were subjected to behavioral examination and sacrificed to study the biochemical and histological parameters. The results showed attenuation of memory and learning capacity, suppression of lipid oxidation (MDA) through regulation of antioxidant content (SOD, CAT, and GSH) and inhibition of lactate dehydrogenase (LDH), nitric oxide (NO), acetylcholinesterase (AChE), and transmembrane protein (Na+K+ATPase) activity. In addition, the NF-ƙB associated mRNA expression (TNF-α IL-6, Il-1β, iNOS, COX-2) was decreased, as evidenced in histopathological results. The present investigation established that the betalain treatment ameliorated the AlCl3 induced AD by modulating NF-κB pathway activation.
PDF
