INTRODUCTIONInhalation injury is a major complication of fire accidents. Delayed onset of tracheal stenosis is one of the chronic complications of inhalation injury. Here, we report a case of acute ...empyema as a complication of inhalation injury.PRESENTATION OF CASEA 38-year-old-man who underwent a tracheostomy following an inhalation injury when he was 25-years of age was admitted with a diagnosis of right-side pyothorax. We attributed the pyothorax to insufficient bronchial toilet secondary to preoperative tracheal stenosis and tracheal mucosal damage as a complication of inhalation injury, as confirmed using laryngofiberscopy. Conservative therapy was insufficient, therefore, surgical drainage was performed. At the time of surgery, following general anesthesia induction, the insertion of a single-lumen tube was difficult owing to severe tracheal stenosis. As a result, we performed an emergency tracheostomy followed by empyema curettage.DISCUSSION/CONCLUSIONTracheal stenosis due to tracheal basal membrane injury and mucosal membrane injury resulted in sputum clearance disorder. These changes led to pyothorax. Preoperative airway safety should be carefully planned when operating on patients with tracheal stenosis.
Three mitochondrial genes, namely orf25, rps7, atp6 of Aegilops crassa, confer structural alterations around their promoter regions in comparison to those of common wheat (Triticum aestivum cv. ...Chinese Spring, CS). PCR analysis to detect such structural alterations showed that each of three lines, pure lines and alloplasmic wheat {(cr)-CS} contains both genotypes, although mitochondrial genotypes of CR in CS, those of CS in CR were still remained as minor fractions. CS mitochondrial gene frequencies in {(cr)-CS} were grown to be ca. 30%. SNPs analysis of these genes indicated that minor types of all mitochondrial genes in alloplasmic wheat were transmitted through pollens. Since the frequencies of paternally transmitted mitochondrial genes in F1 were about 20%, frequencies of paternally transmitted mitochondrial genes were increased by successive back crossing. Expression profiles of those mitochondrial genes were quantitatively analyzed by RT-PCR. Products of paternally transmitted mitochondrial genes were scarcely found. These lines of evidences strongly suggest that paternally transmitted genes/genomes are silenced in the descendants.
The purpose of this study is to clarify the current state of nursing for the sexuality of patients with cancer at the end-of-life. In December 2018, we asked 313 nurses from 18 palliative care units ...in Kanagawa Prefecture about their awareness, feelings, and behavioral intentions and hands-on experience for the environment in which patients with cancer nurture love with their partners at the end-of-life. The collection rate of the questionnaire was 52.7% (165 cases). Eighty-two nurses (49.7%) had experience supporting the environment in which patients with cancer nurture love with their partners at the end-of-life. The contents of the support were “Recommend physical contact”, “Listening”, “Recommend hug”, and “Take sufficient time when entering the room, such as waiting for a reply after knocking or calling out”. Meanwhile, at ward conferences, only 11 (6.7%) had talked about the environment in which patients with cancer nurture love with their partners at the end-of-life. It has been suggested that, at present, support for the environment in which patients with cancer nurture love with their partners at the end-of-life is left to individuals and not systematically.
Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their feactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 ...was competitively inhibited in the presence of synthetic PIP3
C2 and PIP3
C4, respectively.
Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their reactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 was competitively inhibited in the presence of synthetic PIP3
c2 and PIP3
c4, respectively.
Phosphatidylinositol analogs (PI
C2–PI
C18) having a series of saturated fatty acid (C2–C18) at
sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol ...3-kinase (PI 3-kinase). The reactivity of PI
C8 with PI 3-kinase turned out to be comparable to that of natural PI, although PI
C18 was not phosphorylated under the same condition. The chirality of
sn-2 center was not responsible for the phosphorylation reaction.
Synthetic distearate phosphatidylinositol (PI) was not phosphorylated by PI 3-kinase. The fatty acids at glycerol
sn-2 must be as short as octanoic acid or less to act as a substrate of PI 3-kinase.
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The present study compared the quality of life (QOL) of Japanese and Finnish children inrelation to their friendships and school lives to examine the characteristics of Japanesechildren. A ...questionnaire survey was conducted involving 1,420 Japanese and 397 Finnishchildren. The QOL of the Japanese children in relation to their school lives was lower than thatof Finnish ones. There was a significant correlation between "Japanese children's pleasure ofattending school" and their QOL score in relation to friendships. The results suggest thatrelationships with friends in school life are significantly important for Japanese children. It isnecessary to conduct further research to analyze children's relationships with friends, andexamine factors influencing children's school life-associated QOL.
The experience at the time of a patient’s death can affect the mental health of bereaved families. Performing death pronouncements is an important skill for end-of-life care. However, almost no ...educational content regarding death pronouncements is presently included in medical educational programs. We have created a guidebook for “Physician behavior at the time of death pronouncement” based on the results of a questionnaire given to the families of deceased patients that included several items related to this topic. The purpose of this research was to investigate the educational effect of using this guidebook. The guidebook was given to 4th-year medical students attending the Yokohama City University School of Medicine. A survey was then conducted to assess evaluations of self-practice and feelings of difficulty at the time of making death pronouncements both before and after the class. Among the 39 students who provided valid responses, the majority (89.5%) indicated that they had difficulty with the item regarding “the specific method of death pronouncement.” A significant improvement was observed between the responses obtained before and those obtained after the class. We concluded that our guidebook for physician behavior at the time of death pronouncement might be useful for the education of medical students.
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