► Salicylate causes moderate hearing loss and tinnitus at high-dose levels. ► Salicylate reversibly reduced the outward K currents but did not affect the inward currents. ► Salicylate blocked the ...outward K currents in a concentration-dependent manner according to Hill equation.
Although salicylate is one of the most widely used nonsteroidal anti-inflammatory drugs, it causes moderate hearing loss and tinnitus at high-dose levels. In the present study, salicylate effects on the K currents in inner hair cells were examined. Salicylate reversibly reduced the outward K currents (
I
K,f), but did not affect the inward current (
I
K,n). Salicylate blocked the outward K currents in a concentration-dependent manner according to Hill equation with a half-blocking concentration of 1.66
mM, and the Hill coefficient of 1.86.
A case of hyalinizing trabecular tumor MIYAZAKI, Takashi; YAMAMOTO, Ryota; NISHIYAMA, Kazuo ...
jibi to rinsho,
2018/09/20, Volume:
64, Issue:
5
Journal Article
Open access
Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intertrabecular hyalinization. We herein report a case of HTT in a ...26-year-old man with a thyroid goiter. Since the clinical and ultrasonographic features were nonspecific, fine-needle aspiration was performed, which resulted in an indeterminate cytologic diagnosis (category 3). After partial thyroidectomy was performed, an operative rapid pathologic diagnosis revealed that the goiter was a hyalinizing trabecular tumor. The patient therefore did not undergo paratracheal lymph node dissection. There is no unified treatment policy for HTT. If we treat cases of HTT using the protocol for a benign tumor, an operative rapid pathologic diagnosis can provide effective information on whether or not to perform paratracheal lymph node dissection. If we cannot determine the malignancy before the operation, we may still be able to prevent unnecessary paratracheal lymph node dissection by an operative rapid pathologic diagnosis.
We investigated the association between the success rate of the type 1 tympanoplasty and the age in children who had chronic otitis media. We performed 20 tympanoplasty procedures in children of ...between 7 and 14 years of age during the period of January 2008 to March 2014. The overall rate of improvement in hearing was 100% and the overall rate of closure of the perforated tympanic membrane was 80%. The rate of successful closure of the perforation among the patients who were older than 10 years of age tended to be higher that among the younger patients. Thus, if the clinical condition permits waiting, we recommend that type-1 tympanoplasty be used for the treatment of patients who are older than 10 years of age. In cases with otorrhea, it is desirable to control the infection before surgery. If inflammation is persistent, topical antibiotics should be administered, preferably after a bacterial culture test of the middle ear.
We herein report a case of life-threatening invasive fungal sinusitis following allogeneic hematopoietic stem cell transplantation. Since the infection could not be controlled by endoscopic sinus ...surgery or drainage of the infratemporal fossa and orbit, we performed enucleation of the left eye. Although recent case reports have described the successful preservation of eyes with invasive fungal sinusitis, we should consider orbit evisceration to save the patient's life in cases of severe immunodeficiency, such as in patients receiving multiple immunosuppressive treatments.
Hydrogen peroxide (H₂O₂) is a ubiquitous reactive oxygen species that can induce several inner ear disorders. In this study, we recorded the potassium (K) currents in acutely isolated inner hair ...cells of guinea pig cochlea, and investigated the effects of H₂O₂. We also observed the morphological changes in inner hair cells induced by H₂O₂. In the H₂O₂ solutions, the amplitude of outward K currents (I(K,f) and I(K,s)) clearly decreased after perfusion for approximately 15 min. Despite the decrease in outward currents, small inward currents (I(K,n)) did not show any reduction. H₂O₂ induced morphological changes in the inner hair cells. All the inner hair cells in the H₂O₂ solutions showed shrinkage and granularity of the cell body and led to loss of viability. These results showed the vulnerability of inner hair cells to reactive oxygen species-induced inner ear disorders.
Mitochondrial myopathy encephalopathy, lactic acidosis and stroke-like episodes syndrome (MELAS) is a type of mitochondrial disease characterized by recurrently stroke-like episodes. Approximately ...40-60% of patients with MELAS syndrome have sensorineural hearing loss cannot obtain hearing aids. These patients sometimes fall into severe hearing loss. Because the onset of MELAS syndrome is rare, there are limited reports of cochlear implantation in profoundly deaf patients with MELAS syndrome. We herein report cochlear implantation for three mitochondrial encephalomyopathy patients ; two of the patients noticed a significant improvement in communication due to the cochlear implant. Inner ear deafness is often the cause of sensorineural hearing loss associated with mitochondrial encephalomyopathy. However, retrocochlear deafness may also be a cause. We should therefore consider cochlear implant adaptation when retrocochlear deafness is suspected to be the cause.
Background In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the ...periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points. Results We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/planar cell polarity. Conclusion A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.
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