Unsustainable fishing simplifies food chains and, as with aquaculture, can result in reliance on a few economically valuable species. This lack of diversity may increase risks of ecological and ...economic disruptions. Centuries of intense fishing have extirpated most apex predators in the Gulf of Maine (United States and Canada), effectively creating an American lobster (Homarus americanusj monoculture. Over the past 20 years, the economic diversity of marine resources harvested in Maine has declined by almost 70%. Today, over 80% of the value of Maine's fish and seafood landings is from highly abundant lobsters. Inflationcorrected income from lobsters in Maine has steadily increased by nearly 400% since 1985. Fisheries managers, policy makers, and fishers view this as a success. However, such lucrative monocultures increase the social and ecological consequences of future declines in lobsters. In southern New England, disease and stresses related to increases in ocean temperature resulted in more than a 70% decline in lobster abundance, prompting managers to propose closing that fishery. A similar collapse in Maine could fundamentally disrupt the social and economic foundation of its coast. We suggest the current success of Maine's lobster fishery is a gilded trap. Gilded traps are a type of social trap in which collective actions resulting from economically attractive opportunities outweigh concerns over associated social and ecological risks or consequences. Large financial gain creates a strong reinforcing feedback that deepens the trap. Avoiding or escaping gilded traps requires managing for increased biological and economic diversity. This is difficult to do prior to a crisis while financial incentives for maintaining the status quo are large. The long-term challenge is to shift fisheries management away from single species toward integrated social-ecological approaches that diversify local ecosystems, societies, and economies. La pesca no sustentable simplifica las cadenas alimenticias y, como la acuicultura, puede resultar en una dependencia en unas cuantas especies valiosas económicamente. Esta falta de biodiversidad puede incrementar los riesgos de disrupciones ecológicas y económicas. Siglos de pesca intensiva ban extirpado a la mayoría de los depredadores superiores en el Golfo de Maine (E.U.A. y Canadá), creando efectivamente un monocultivo de langosta americana Homarus americanus). Durante los últimos 20 años, la diversidad económica de los recursos marinos cosechados en Maine ha declinado en casi 70%. Ahora, más de 80% del valor de las capturas de peces y mariscos consiste en langostas que son muy abundantes. El ingreso, corregido para la inflación, por langostas ha incrementado consistentemente en casi 400% desde 1985. Manejadores de pesquerías, políticos y Pescadores ven esto como un éxito. Sin embargo, tales monocultivos lucrativos incrementan las consecuencias sociales y ecológicas de declinaciones de langostas en el futuro. En el sur de Nueva Inglaterra, las enfermedades y los estreses relacionados con incrementos en la temperatura del océano resultaron en una declinación de mas de 70% en la abundancia de langostas, lo que obligó a la propuesta del cierre de esa pesquería. Un colapso similar en Maine podría desestabilizar la base social y económica de su costa. Sugerimos que el éxito actual de la pesquería de langosta en Maine es una trampa dorada. Las trampas doradas son un tipo de trampa social en el que las acciones colectivas derivadas de oportunidades atractivas económicamente sobrepasan a las preocupaciones por los riesgos o consecuencias ecológicas y sociales asociadas. El gran ingreso financiero crea una fuerte retroalimentación reforzante que profundiza la trampa. Escapar de o evitar las trampas doradas requiere de manejo para el incremento de la diversidad biológica y ecológica. Esto es difícil de hacer antes de una crisis mientras los incentivos financieros para mantener el status quo son grandes. El reto a largo plazo es cambiar el manejo de pesquerías de una sola especie hacia enfoques sociales-ecológicos integrados que diversifiquen los ecosistemas, las sociedades y las economías locales.
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in ...BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920-1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html).
•Residual harm defined as variation in alcohol harms given binge-drinking frequency.•Mental health, social skills, and relationship qualities were important predictors.•Most associations persisted ...across adolescence and young adulthood.
We examine the extent to which adolescent and young adult psychosocial factors are associated with variation in the experience of common types of harm (e.g., injuries, violence, sexual regrets) with respect to binge-drinking frequency – termed residual harm.
Data were from the Australian Temperament Project, a population-based cohort study that has followed a sample of young Australians from infancy to adulthood since 1983. The current sample comprised 1,081 (565 women). Residual harm was operationalised by saving residuals from models regressing number of alcohol harms onto binge-drinking frequency at each of 5 waves, two in adolescence (15–16 and 17–18 years) and three in young adulthood (19–20, 23–24, and 27–28 years). Psychosocial factors (mental health, social skills, quality of parent and peer relationships) were assessed prior to binge drinking in early adolescence (13–14 years) and then again in young adulthood (19–20 years).
Adolescent predictors of decreased residual harm were lower depressive symptoms, and higher cooperation, self-control, and peer and parent attachment. Young adult predictors of decreased residual harm were lower depressive, anxiety, and stress symptoms and peer and parent negative appraisal, and higher responsibility, and peer and parent emotional support. Associations were evident in males and females, although the strength of some associations diminished with age.
Adolescents and young adults with better mental health, social skills, and relationship quality experienced less harm with respect to their binge-drinking frequency. Future research should examine the potential of investment in strength-based interventions for young people.
Respiratory metabolism plays an important role in energy production in the form of ATP in all aerobically growing cells. However, a limitation in respiratory capacity results in overflow metabolism, ...leading to the formation of byproducts, a phenomenon known as "overflow metabolism" or "the Crabtree effect." The yeast Saccharomyces cerevisiae has served as an important model organism for studying the Crabtree effect. When subjected to increasing glycolytic fluxes under aerobic conditions, there is a threshold value of the glucose uptake rate at which the metabolism shifts from purely respiratory to mixed respiratory and fermentative. It is well known that glucose repression of respiratory pathways occurs at high glycolytic fluxes, resulting in a decrease in respiratory capacity. Despite many years of detailed studies on this subject, it is not known whether the onset of the Crabtree effect is due to limited respiratory capacity or is caused by glucose-mediated repression of respiration. When respiration in S. cerevisiae was increased by introducing a heterologous alternative oxidase, we observed reduced aerobic ethanol formation. In contrast, increasing nonrespiratory NADH oxidation by overexpression of a water-forming NADH oxidase reduced aerobic glycerol formation. The metabolic response to elevated alternative oxidase occurred predominantly in the mitochondria, whereas NADH oxidase affected genes that catalyze cytosolic reactions. Moreover, NADH oxidase restored the deficiency of cytosolic NADH dehydrogenases in S. cerevisiae. These results indicate that NADH oxidase localizes in the cytosol, whereas alternative oxidase is directed to the mitochondria.
We report population-based concentrations, stratified by age, sex, and racial/ethnic groups, of dialkyl phosphate (DAP) metabolites of multiple organophosphorus pesticides. We measured ...dimethylphosphate (DMP), dimethylthiophosphate (DMTP), dimethyldithiophosphate (DMDTP), diethylphosphate (DEP), diethylthiophosphate (DETP), and diethyldithiophosphate (DEDTP) concentrations in 1,949 urine samples collected in U.S. residents 6-59 years of age during 1999 and 2000 as a part of the ongoing National Health and Nutrition Examination Survey (NHANES). We detected each DAP metabolite in more than 50% of the samples, with DEP being detected most frequently (71%) at a limit of detection of 0.2 μg/L. The geometric means for the metabolites detected in more than 60% of the samples were 1.85 μg/L for DMTP and 1.04 μg/L for DEP. The 95th percentiles for each metabolite were DMP, 13 μg/L; DMTP, 46 μg/L; DMDTP, 19 μg/L; DETP, 2.2 μg/L; and DEDTP, 0.87 μg/L. We determined the molar sums of the dimethyl-containing and diethyl-containing metabolites; their geometric mean concentrations were 49.4 and 10.5 nmol/L, respectively, and their 95th percentiles were 583 and 108 nmol/L, respectively. These data are also presented as creatinine-adjusted concentrations. Multivariate analyses showed concentrations of DAPs in children 6-11 years of age that were consistently significantly higher than in adults and often higher than in adolescents. Although the concentrations between sexes and among racial/ethnic groups varied, no significant differences were observed. These data will be important in evaluating the impact of organophosphorus pesticide exposure in the U.S. population and the effectiveness of regulatory actions.
All-optical label swapping is a promising approach to ultra-high packet-rate routing and forwarding directly in the optical layer. In this paper, we review results of the DARPA Next Generation ...Internet program in all-optical label swapping at University of California at Santa Barbara (UCSB). We describe the overall network approach to encapsulate packets with optical labels and process forwarding and routing functions independent of packer bit rate and format. Various approaches to label coding using serial and subcarrier multiplexing addressing and the associated techniques for label erasure and rewriting, packet regeneration and packet-rate wavelength conversion are reviewed. These functions have been implemented using both fiber and semiconductor-based technologies and the ongoing effort at UCSB to integrate these functions is reported. We described experimental results for various components and label swapping functions and demonstration of 40 Gb/s optical label swapping. The advantages and disadvantages of using the various coding techniques and implementation technologies are discussed.
Germline mutations in
BRCA1 and
BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on ...multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We pooled pedigree data from 22 studies involving 8,139 index case patients unselected for family history with female (86%) or male (2%) breast cancer or epithelial ovarian cancer (12%), 500 of whom had been found to carry a germline mutation in
BRCA1 or
BRCA2. Breast and ovarian cancer incidence rates for mutation carriers were estimated using a modified segregation analysis, based on the occurrence of these cancers in the relatives of mutation-carrying index case patients. The average cumulative risks in
BRCA1-mutation carriers by age 70 years were 65% (95% confidence interval 44%–78%) for breast cancer and 39% (18%–54%) for ovarian cancer. The corresponding estimates for
BRCA2 were 45% (31%–56%) and 11% (2.4%–19%). Relative risks of breast cancer declined significantly with age for
BRCA1-mutation carriers (
P trend .0012) but not for
BRCA2-mutation carriers. Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age. We found some evidence for a reduction in risk in women from earlier birth cohorts and for variation in risk by mutation position for both genes. The pattern of cancer risks was similar to those found in multiple-case families, but their absolute magnitudes were lower, particularly for
BRCA2. The variation in risk by age at diagnosis of index case is consistent with the effects of other genes modifying cancer risk in carriers.
The influence of surface micro topography of CVD α-Al2O3 coatings, deposited on cemented carbide inserts, on tribological characteristics in sliding contact and in metal cutting has been investigated ...using quenched and tempered steel as counter/work material. Pin-on-disc and turning tests were carried out and post-test characterization using 3D optical surface profilometry and scanning electron microscopy was performed in order to investigate the tribological response of the coatings. The results show that surface micro topography can have a significant impact on the tribological performance of Al2O3 coatings under initial and cutting contact conditions. For both kinds of tests the tendency for transfer of workpiece material strongly increases with increasing coating micro topography. In the pin-on-disc tests, a smooth coating surface significantly reduces the friction coefficient. In the turning tests the contact conditions at the flank face increase with decreasing micro topography. In contrast, no general conclusions can be drawn regarding the influence of coating micro topography on the contact conditions at the rake face. The resulting topography of the turned surface was found to increase with increasing coating topography.
► Smooth coating reduces the interaction between coating and workpiece material. ► Contact conditions at flank face increases with decreasing coating topography. ► The choice of calculating method strongly influences the contact conditions. ► There exists an optimal value of the coating topography at the rake face.
The aims of the study were to describe the patterning and persistence of anxiety and depressive symptoms from adolescence to young adulthood and to examine long-term developmental relationships with ...earlier patterns of internalizing behaviours in childhood.
We used parallel processes latent growth curve modelling to build trajectories of internalizing from adolescence to adulthood, using seven waves of follow-ups (ages 11-27 years) from 1406 participants of the Australian Temperament Project. We then used latent factors to capture the stability of maternal reported child internalizing symptoms across three waves of early childhood follow-ups (ages 5, 7 and 9 years), and examined relationships among these patterns of symptoms across the three developmental periods, adjusting for gender and socio-economic status.
We observed strong continuity in depressive symptoms from adolescence to young adulthood. In contrast, adolescent anxiety was not persistent across the same period, nor was it related to later depressive symptoms. Anxiety was, however, related to non-specific stress in young adulthood, but only moderately so. Although childhood internalizing was related to adolescent and adult profiles, the associations were weak and indirect by adulthood, suggesting that other factors are important in the development of internalizing symptoms.
Once established, adolescent depressive symptoms are not only strongly persistent, but also have the potential to differentiate into anxiety in young adulthood. Relationships with childhood internalizing symptoms are weak, suggesting that early adolescence may be an important period for targeted intervention, but also that further research into the childhood origins of internalizing behaviours is needed.
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