PURPOSE: We seek to identify genetic loci that contribute to age-related maculopathy susceptibility.
METHODS: Families consisting of at least two siblings affected by age-related maculopathy were ...ascertained using eye care records and fundus photographs. Additional family members were used to increase the power to detect linkage. Microsatellite genotyping was conducted by the National Heart, Lung and Blood Institute Mammalian Genotyping Service and the National Institutes of Health Center for Inherited Disease Research. Linkage analyses were conducted with parametric (autosomal dominant; heterogeneity lod score) and nonparametric methods (S
all statistic) using three diagnostic models. False-positive rates were determined from simulations using actual pedigrees and genotyping data.
RESULTS: Under our least stringent diagnostic model, model C, 860 affected individuals from 391 families (452 sib pairs) were genotyped. Sixty-five percent of the affected individuals had evidence of exudative disease. Four regions, 1q31, 9p13, 10q26, and 17q25, showed multipoint heterogeneity lod scores or S
all scores of 2.0 or greater (under at least one model). Under our most stringent diagnostic model, model A, the 1q31 heterogeneity lod score was 2.46 between D1S1660 and D1S1647. Under model C, the 17q25 heterogeneity lod score at D17S928 was 3.16. Using a threshold of 1.5, additional loci on chromosomes 2 and 12 were identified.
CONCLUSIONS: The locus on chromosome 1q31 independently confirms a report by Klein and associates mapping an age-related maculopathy susceptibility gene to this region. Simulations indicate that the 1q31 and 17q25 loci are unlikely to be false positives. There was no evidence that other known macular or retinal dystrophy candidate gene regions are major contributors to the genetics of age-related maculopathy.
Angioid streaks were observed in two patients with abetalipoproteinemia. The progression of the angioid streaks was minimal over the years that these patients received vitamin A and E ...supplementation, though in one patient the development of subretinal neovascular membranes within the angioid streaks was the cause of rapid central visual loss. The simultaneous appearance of two rare entities in unrelated individuals strengthens the relationship between these two disorders that has been suggested by previous case studies. The authors propose a common metabolic pathway involving trace element deficiencies that may account for this relationship as well as the association of angioid streaks with other rare disorders such as Paget's disease, hypoparathyroidism, lead poisoning, hyperphosphatemia, and a number of hemoglobinopathies. Their study of these two patients underscores the need for further investigations as to the role of copper, zinc and omega-3 fatty acids in the pathogenesis of retinopathy in abetalipoproteinemia.
Vasectomy and increased risk of prostate cancer Sidney, S; Quesenberry, Jr, C P; Sadler, M C ...
JAMA : the journal of the American Medical Association,
1993-Aug-11, Volume:
270, Issue:
6
Journal Article
Curatorial Reports Howat, John K.; Harper, Prudence O.; Pyhrr, Stuart W. ...
Annual report of the Trustees (Metropolitan Museum of Art (New York, N.Y.)),
07/1988
119
Journal Article
Reviews of Books van Nijf, Onno M.; Barua, Pradeep; Isayev, Elena ...
The International History Review,
12/1/2005, Volume:
27, Issue:
4
Book Review
Peer reviewed
NIGEL SPIVEY. The Ancient Olympics. New York: Oxford University Press, 2004. Pp. xxi, 273. $39-95 (CDN). Reviewed by Onno M. van Nijf
KAUSHIK ROY. From Hydaspes to Kargil: A History of Warfare in ...India from 326 BC to AD 1999. New Delhi: Manohar, 2004. Pp. 283. Rs 595. Reviewed by Pradeep Barua
NATHAN ROSENSTEIN. Rome at War: Farms, Families, and Death in the Middle Republic. Chapel Hill and London: University of North Carolina Press, 2004; dist. Toronto: SBS. Pp. x, 339. $45.00 (us). Reviewed by Elena Isayev
HENRY CHADWICK. East and West: The Making of a Rift in the Church: From Apostolic Times until the Council of Florence. New York: Oxford University Press, 2003. Pp. x,306. $203.00 (CDN). Reviewed by Ian Wood
CHRISTOPHER TYERMAN. Fighting for Christendom: Holy War and the Crusades. New York: Oxford University Press, 2004. Pp. xv, 247. $37.50 (CDN). Reviewed by Jonathan Riley-Smith
MARGARET L. KEKEWICH and SUSAN ROSE. Britain, France, and the Empire, 1350-1500. Basingstoke and New York: Palgrave Macmillan, 2005. Pp. xxiii, 308. $23.95 (us), paper. Reviewed by John France
OM PRAKASH. Bullion for Goods: European and Indian Merchants in the Indian Ocean Trade, 1500-1800. New Delhi: Manohar, 2004. Pp. 426. Rs 850. Reviewed by Anthony Disney
HARRO HÖPFL. Jesuit Political Thought: The Society of Jesus and the State, c.1540-1630. New York: Cambridge University Press, 2004. Pp. xii, 406. $90.00 (us). Reviewed by John Patrick Donnelly, SJ
RICHMOND BARBOUR. Before Orientalism: London's Theatre of the East, 1576-1626. New York: Cambridge University Press, 2003. Pp. xii, 238. $75.00 (us). Reviewed by Lawrence Manley
LYNN A. STRUVE, ed. The Qing Formation in World-Historical Time. Cambridge, MA and London: Harvard University Asia Center, Harvard University Press, 2004. Pp. xiv, 412. $49.50 (us). Reviewed by John W. Dardess
FA-TI FAN. British Naturalists in Qing China: Science, Empire, and Cultural Encounter. Cambridge, MA and London: Harvard University Press, 2004. Pp. xi, 238. $49-95 (us). Reviewed by Peter C. Perdue
KRISTINA BROSS. Dry Bones and Indian Sermons: Praying Indians in Colonial America. Ithaca and London: Cornell University Press, 2004. Pp. x, 357. $21.95 (us), paper. Reviewed by Daniel K. Richter
RAFAEL DE BIVAR MARQUESE. Feitores do corpo, missionários da mente: Senhores, letrados e o controle dos escravos nos Américas, 1660-1860. Sao Paulo: Companhia das Letras, 2004. Pp. 479. R$66.oo. Reviewed by Enrico Dal Rago
JAMES PRITCHARD. In Search of Empire: The French in the Americas, 1670-1730. New York: Cambridge University Press, 2004. Pp. xxvii, 484. $75.00 (us). Reviewed by John G. Reid
JOHN D. GRAINGER. The Amiens Truce: Britain and Bonaparte, 1801-1803. Rochester, NY: Boydell Press, 2004. Pp. xi, 222. $85.00 (us). Reviewed by Simon Burrows
TIMOTHY HAWKINS. José de Bustamante and Central American Independence: Colonial Administration in an Age of Imperial Crisis. Tuscaloosa: University of Alabama Press, 2004. Pp. xxviii, 283. $40.00 (us). Reviewed by Mark A. Burkholder
JON KUKLA. A Wilderness So Immense: The Louisiana Purchase and the Destiny of America. New York: Alfred A. Knopf, 2003; dist. Toronto: Random House of Canada. Pp. x, 430. $45.00 (CDN). Reviewed by H. W. Brands
JULIAN GWYN. Ashore and Afloat: The British Navy and the Halifax Naval Yard before 1820. Ottawa: University of Ottawa Press, 2004; dist. Toronto: University of Toronto Press. Pp. xvii, 366. $60.00 (CDN), clodi; $35.00 (CDN), paper. Reviewed by Daniel A. Baugh
TREVOR R. GETZ. Slavery and Reform in West Africa: Toward Emancipation in Nineteenth-Century Senegal and the Gold Coast. Athens: Ohio University Press; and Oxford: James Currey, 2004. Pp. xix, 257. $65.00 (us). Reviewed by Gregory Mann
ANDREAS NEHRING. Orientalismus und Mission: Die Repräsentation der tamilischen Gesellschaft und Religion durch Leipziger Missionare, 1840-1940. Wiesbaden: Harrassowitz Verlag, 2003. Pp. 500. €48.00. Reviewed by Penelope Carson
BRUCE L. BATTEN. To the Ends of Japan: Premodern Frontiers, Boundaries, and Interactions. Honolulu: University of Hawaii Press, 2003. Pp. xiii, 337. $39.00 (us). Reviewed by Mark J. Hudson
CHARLES DESNOYERS, trans, widi an intro. A Journey to the East: Li Gui's A New Account of a Trip around the Globe. Ann Arbor: University of Michigan Press, 2004. Pp. xii, 320. $70.00 (us). Reviewed by Richard J. Smith
ISABEL V. HULL. Absolute Destruction: Military Culture and the Practices of War in Imperial Germany. Ithaca and London: Cornell University Press, 2005. Pp. xi, 384. $45.00 (us). Reviewed by Holger H. Herwig
JOHN C. G. RÖHL. Wilhelm II: The Kaiser's Personal Monarchy, 1888-1900, trans. Sheila de Bellaigue. New York: Cambridge University Press, 2004. Pp. xxi, 1,287. $150.00 (us). Reviewed by Lamar Cecil
JAMES BENNETT. 'Rats and Revolutionaries': The Labour Movement in Australia and New Zealand, 1890-1940. Dunedin: University of Otago Press, 2004; dist. Portland, OR: ISBS. Pp. 214. $39.95 (us), paper. Reviewed by Donald Denoon
TONY KUSHNER. We Europeans? Mass-Observation, 'Race', and British Identity in the Twentieth Century. Aldershot and Burlington: Ashgate, 2004. Pp. xi, 281. $99.95 (us). Reviewed by Martin Francis
MIRA WILKINS. The History of Foreign Investment in the United States, 1914-1945. Cambridge, MA and London: Harvard University Press, 2004. Pp. xxvi, 980. $95.00 (us). Reviewed by Alfred E. Eckes
TANJA LUCKINS. The Gates of Memory: Australian People's Experiences and Memories of Loss and the Great War. Fremande: Curtin University Books, 2004; dist. Portland, OR: ISBS. Pp. 304. $26.95 (us). Reviewed by Christina Twomey
PHILIP AYRES. Owen Dixon. Melbourne: Miegunyah Press, Melbourne University Publishing, 2003; dist. Chicago: Paul & Company. Pp. xx, 400. $49.95 (us). Reviewed by Geoffrey Bolton
MICHAEL D. CALLAHAN. A Sacred Trust: The League of Nations and Africa, 1929-1946. Brighton and Portland, OR: Sussex Academic Press, 2004. Pp. ix, 308. $69.50. Reviewed by James Searing
JEFFREY J. MATTHEWS. Alanson B. Houghton: Ambassador of the New Era. Lanham: Scholarly Resources, 2004. Pp. xxii, 263. $26.95 (us), paper. Reviewed by Anders Stephanson
HENRIK LUNDBAK. Danish Unity: A Political Party between Fascism and Resistance, 1936-1947. Copenhagen: Museum Tusculanum Press, University of Copenhagen, 2003; dist. Pordand, OR: ISBS. Pp.312. $31.00 (us). Reviewed by Nils Arne Sorensen
UWE LÜBKEN. Bedrohliche Nähe: Die USA und die nationalsozialistische Herausforderung in Lateinamerika, 1937-1945. Stuttgart: Franz Steiner Verlag, 2004. Pp. 438. €50.00. Reviewed by Andreas Fahrmer
JOSHUA H. HOWARD. Workers at War: Labor in China's Arsenals, 1937-1953. Stanford: Stanford University Press, 2004. Pp. xix, 452. $70.00 (us). Reviewed by Stephen G. Graft
S. P. MACKENZIE. The Colditz Myth: British and Commonwealth Prisoners of War in Nazi Germany. New York: Oxford University Press, 2004. Pp. xiv, 446. $57.00 (CDN). Reviewed by Barbara Hately-Broad
STEPHEN G. FRITZ. Endkampf: Soldiers, Civilians, and the Death of the Third Reich. Lexington: University Press of Kentucky, 2004; dist. Toronto: Scholarly Book Services. Pp. xvii, 382. $57-75 (CDN). Reviewed by Jill Stephenson
JAMES C. VAN HOOK. Rebuilding Germany: The Creation of the Social Market Economy, 1945-1957. New York: Cambridge University Press, 2004. Pp. xiv, 312. $70.00 (us). Reviewed by Gary Herrigel
PATRICK IRELAND. Becoming Europe: Immigration, Integration, and the Welfare State. Pittsburgh: University of Pittsburgh Press, 2004. Pp. xii, 274. $27.95 (us)> paper. Reviewed by Judith Roosblad
WILLIAM J. DAUGHERTY. Executive Secrets: Covert Action and the Presidency. Lexington: University Press of Kentucky, 2004. Pp. xxiii, 298. $32.50 (us). Reviewed by James C. Van Hook
HERMAN LEBOVICS. Bringing the Empire Back Home: France in the Global Age. Durham, NC and London: Duke University Press, 2004. Pp. xvi, 232. $29.95 (us). Reviewed by Donald Reid
GERT OOSTINDIE and INGE KLINKERS. Decolonizing the Caribbean: Dutch Policies in a Comparative Perspective. Amsterdam: Amsterdam University Press, 2003; dist. Chicago: University of Chicago Press. Pp. 291. $35.00 (us), paper. Reviewed by Helen Hitjens
NICHOLAS TARLING. International Students in New Zealand: The Making of Policy since 1950. Auckland: New Zealand Asia Institute, University of Auckland, 2004. Pp. 238. $35.00 (NZ), paper. Reviewed by Ann Trotter
MICHAEL J. COHEN. Strategy and Politics in the Middle East, 1954-1960. London and New York: Frank Cass, 2005. Pp. xiii, 272. $65.00 (us); CLIVE JONES. Britain and the Yemen Civil War, 1962-1965: Ministers, Mercenaries, and Mandarins: Foreign Policy and the Limits of Covert Action. Brighton and Portland: Sussex Academic Press, 2004. Pp. ix, 273. $69.95 (us). Reviewed by Tore Tingvold Petersen
CIHAT GÖKTEPE. British Foreign Policy towards Turkey, 1959-1965. London and New York: Frank Cass, 2003. Pp. xii, 236. $59.60 (us). Reviewed by Nur Bilge Criss
MARTIN KOFLER. Kennedy und Österreich: Neutralität im Kalten Krieg. Innsbruck: Studien Verlag, 2003. Pp. 181. €19.50, paper. Reviewed by Ronald J. Granieri
ALICE L. GEORGE. Awaiting Armageddon: How Americans Faced the Cuban Missile Crisis. Chapel Hill and London: University of North Carolina Press, 2003; dist. Toronto: SBS. Pp. xxiii, 238. $49.50 (CDN). Reviewed by G. F. Goodwin
HOWARD JONES. Death of a Generation: How the Assassinations of Diem and JFK Prolonged the Vietnam War. New York: Oxford University Press, 2003. Pp. x, 562. $56.00 (CDN). Reviewed by Ralph B. Levering
GIL FEILER. Economic Relations between Egypt and the Gulf Oil States, 1967-2000: Petro-Wealth and Patterns of Influence. Brighton and Portland, OR: Sussex Academic Press, 2003. Pp. xx, 407. $69.95 (us). Reviewed by Robert Looney
JUSSI HANHIMÄKI. The Flawed Architect: Henry Kissinger and American Foreign Policy. New York: Oxford University Press, 2004. Pp. xxii, 554. $39.95 (CDN). Reviewed by Richard C. Thornton
DAVID FARBER. Taken Hostage: The Iran Hostage Crisis and America's F
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