Applications of 2D semiconductors have been extensively studied, much oriented to various electron devices. Recently, multivalue field‐effect transistors (FETs) are also included among 2D‐based ...electron device studies in consideration that multivalue FETs may resolve power consumption issues in future integrated circuits. Several n‐channel devices are thus reported along with a few p‐channel devices, while studies to achieve both n‐ and p‐channel multivalue FETs are hardly found. Here, both n‐ and p‐channel multivalue FETs are fabricated using p‐MoTe2/n‐MoS2 heterostack channel architecture, where either p‐ or n‐channel ternary value FET is reproducible by switching the stacking order of p‐ and n‐channel layer. The main ternary value mechanism originates from resonant tunneling type injection and channel inversion, which take place during device operation. For a state‐of‐the‐art device application in 2D electronics, a quaternary NAND logic circuit is for the first time demonstrated by integrating two ternary n‐channel FETs, and a complementary ternary inverter is also fabricated by integrating multivalue p‐channel and plain n‐channel FET.
Both n‐ and p‐channel multivalue field‐effect transistors (FETs) are fabricated using p‐MoTe2/n‐MoS2 heterostack channel architecture, where either p‐ or n‐channel ternary value FET is reproducible by switching the stacking order. For a state‐of‐the‐art device application, a quaternary NAND logic circuit is for the first time demonstrated by integrating two ternary n‐channel FETs, and a complementary ternary inverter is also fabricated.
Cancer is the leading cause of mortality worldwide. Various chemotherapeutic drugs have been extensively used for cancer treatment. However, current anticancer drugs cause severe side effects and ...induce resistance. Therefore, the development of novel and effective anticancer agents with minimal or no side effects is important. Notably, natural compounds have been highlighted as anticancer drugs. Among them, many researchers have focused on mushrooms that have biological activities, including antitumor activity. The aim of this review is to discuss the anticancer potential of different mushrooms and the underlying molecular mechanisms. We provide information regarding the current clinical status and possible modes of molecular actions of various mushrooms and mushroom-derived compounds. This review will help researchers and clinicians in designing evidence-based preclinical and clinical studies to test the anticancer potential of mushrooms and their active compounds in different types of cancers.
Coupling between non‐toxic lead‐free high‐k materials and 2D semiconductors is achieved to develop low voltage field effect transistors (FETs) and ferroelectric non‐volatile memory transistors as ...well. In fact, low voltage switching ferroelectric memory devices are extremely rare in 2D electronics. Now, both low voltage operation and ferroelectric memory function have been successfully demonstrated in 2D‐like thin MoS2 channel FET with lead‐free high‐k dielectric BaxSr1‐xTiO3 (BST) oxides. When the BST surface is coated with a 5.5‐nm‐ultrathin poly(methyl methacrylate) (PMMA)‐brush for improved roughness, the MoS2 FET with BST (x = 0.5) dielectric results in an extremely low voltage operation at 0.5 V. Moreover, the BST with an increased Ba composition (x = 0.8) induces quite good ferroelectric memory properties despite the existence of the ultrathin PMMA layer, well switching the MoS2 FET channel states in a non‐volatile manner with a ±3 V low voltage pulse. Since the employed high‐k dielectric and ferroelectric oxides are lead‐free in particular, the approaches for applying high‐k BST gate oxide for 2D MoS2 FET are not only novel but also practical towards future low voltage nanoelectronics and green technology.
Lead‐free inorganic high‐k dielectric BaxSr1–xTiO3 oxides are successfully introduced to support MoS2 channels in field effect transistors, targeting both extremely low voltage operation and ferroelectric nonvolatile memory function by simply adjusting the composition ratio of Ba and Sr.
Objective
There is no scale for rating the severity of autoimmune encephalitis (AE). In this study, we aimed to develop a novel scale for rating severity in patients with diverse AE syndromes and to ...verify the reliability and validity of the developed scale.
Methods
The key items were generated by a panel of experts and selected according to content validity ratios. The developed scale was initially applied to 50 patients with AE (development cohort) to evaluate its acceptability, reproducibility, internal consistency, and construct validity. Then, the scale was applied to another independent cohort (validation cohort, n = 38).
Results
A new scale consisting of 9 items (seizure, memory dysfunction, psychiatric symptoms, consciousness, language problems, dyskinesia/dystonia, gait instability and ataxia, brainstem dysfunction, and weakness) was developed. Each item was assigned a value of up to 3 points. The total score could therefore range from 0 to 27. We named the scale the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). The new scale showed excellent interobserver (intraclass correlation coefficient ICC = 0.97) and intraobserver (ICC = 0.96) reliability for total scores, was highly correlated with modified Rankin scale (r = 0.86, p < 0.001), and had acceptable internal consistency (Cronbach α = 0.88). Additionally, in the validation cohort, the scale showed high interobserver reliability (ICC = 0.99) and internal consistency (Cronbach α = 0.92).
Interpretation
CASE is a novel clinical scale for AE with a high level of clinimetric properties. It would be suitable for application in clinical practice and might help overcome the limitations of current outcome scales for AE. ANN NEUROL 2019;85:352–358.
Display omitted
•Carbon nanotubes activate persulfates via nonradical mechanisms.•The CNT/persulfate system effectively oxidizes phenolic compounds.•Reactive complexes of CNT–persulfate are ...responsible for the compound degradation.
Carbon nanotubes (CNTs) have been found to activate persulfates (i.e., peroxymonosulfate and peroxydisulfate) into reactive species that are capable of oxidizing organic compounds in water. In the presence of single- or multi-walled CNTs, persulfates effectively degraded phenolic compounds and certain pharmaceuticals. Phenyl derivatives substituted with electron-withdrawing groups, such as benzoic acid and nitrobenzene, were resistant to degradation by the CNT/persulfate system. Based on observations regarding persulfate decomposition and linear sweep voltammetry using a CNT electrode, it has been suggested that persulfates bind onto the surface of CNTs, forming reactive complexes that are immediately decomposed upon reaction with organic compounds. Electron paramagnetic resonance spectroscopy with spin-trapping indicates that these reactive species are distinct from sulfate radical anions or hydroxyl radicals. The CNT-activated persulfate system shows promise as a novel treatment technology for the selective oxidation of organic contaminants in water.
Growth mindset in mathematics is an approach to teaching mathematics, believing that students' abilities can be developed with efforts, strategies, and support. With a sample of 178 middle school ...students, this study proposed a scale for mathematical mindset utilizing Boaler's positive norms in teaching mathematics and collected evidence for initial validation. The scale was unidimensional and reliable. Specifically, it was highly reliable for middle to low mathematical mindset levels. However, measurement precision was not as desirable in assessing high‐level mathematical mindset. The convergent and discriminant evidence was established in relation to growth mindset, math anxiety, and math engagement. Item response theory analysis showed that the response categories properly gauged different levels of mathematical mindset. In sum, the results supported the scale to be a psychometrically sound measure of mathematical mindset. Implications for future studies and proper use of the scale were further discussed.
Practitioner points
The mathematical mindset items originated from the positive norms and rules viewing mathematics as a subject of growth.
The scale was psychometrically sound and proven to measure a math‐specific feature distinctive from the general growth mindset.
The scale was recommended for adolescents and revealed higher precision in assessing middle to low mathematical mindset levels.
Chronic stress induces adaptive changes in the brain via the cumulative action of glucocorticoids, which is associated with mood disorders. Here we show that repeated daily five-minute restraint ...resolves pre-existing stress-induced depressive-like behavior in mice. Repeated injection of glucocorticoids in low doses mimics the anti-depressive effects of short-term stress. Repeated exposure to short-term stress and injection of glucocorticoids activate neurons in largely overlapping regions of the brain, as shown by c-Fos staining, and reverse distinct stress-induced gene expression profiles. Chemogenetic inhibition of neurons in the prelimbic cortex projecting to the nucleus accumbens, basolateral amygdala, or bed nucleus of the stria terminalis results in anti-depressive effects similarly to short-term stress exposure, while only inhibition of neurons in the prelimbic cortex projecting to the bed nucleus of the stria terminalis rescues defective glucocorticoid release. In summary, we show that short-term stress can reverse adaptively altered stress gains and resolve stress-induced depressive-like behavior.
In eukaryotic cells, mitochondria are closely tethered to the endoplasmic reticulum (ER) at sites called mitochondria‐associated ER membranes (MAMs). Ca2+ ion and phospholipid transfer occurs at MAMs ...to support diverse cellular functions. Unlike those in yeast, the protein complexes involved in phospholipid transfer at MAMs in humans have not been identified. Here, we determine the crystal structure of the tetratricopeptide repeat domain of PTPIP51 (PTPIP51_TPR), a mitochondrial protein that interacts with the ER‐anchored VAPB protein at MAMs. The structure of PTPIP51_TPR shows an archetypal TPR fold, and an electron density map corresponding to an unidentified lipid‐like molecule probably derived from the protein expression host is found in the structure. We reveal functions of PTPIP51 in phospholipid binding/transfer, particularly of phosphatidic acid, in vitro. Depletion of PTPIP51 in cells reduces the mitochondrial cardiolipin level. Additionally, we confirm that the PTPIP51–VAPB interaction is mediated by the FFAT‐like motif of PTPIP51 and the MSP domain of VAPB. Our findings suggest that PTPIP51 is a phospholipid transfer protein with a MAM‐tethering function.
SYNOPSIS
The crystal structure and biochemical analyses of PTPIP51, a mitochondrial protein localized at the mitochondria‐associated ER membrane (MAM), revealed its phospholipid binding and transfer activity.
The crystal structure of the TPR domain of PTPIP51 at 1.45 Å resolution revealed the presence of a lipid‐like serpentine electron density.
PTPIP51 has phospholipid (especially phosphatidic acid) binding and transfer functions in vitro.
Mitochondrial cardiolipin levels are affected by PTPIP51.
The crystal structure and biochemical analyses of PTPIP51, a mitochondrial protein localized at the mitochondria‐associated ER membrane (MAM), revealed its phospholipid binding and transfer activity.
The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily on the responses of the neurovascular unit. Here, we report the development and applicability of a ...functional neurovascular unit on a microfluidic chip as a microphysiological model of ischaemic stroke that recapitulates the function of the blood-brain barrier as well as interactions between therapeutic stem cells and host cells (human brain microvascular endothelial cells, pericytes, astrocytes, microglia and neurons). We used the model to track the infiltration of a number of candidate stem cells and to characterize the expression levels of genes associated with post-stroke pathologies. We observed that each type of stem cell showed unique neurorestorative effects, primarily by supporting endogenous recovery rather than through direct cell replacement, and that the recovery of synaptic activities is correlated with the recovery of the structural and functional integrity of the neurovascular unit rather than with the regeneration of neurons.
PDF
